DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and Pvr

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster

Alignment Length:	1103	Identity:	261/1103 - (23%)
Similarity:	432/1103 - (39%)	Gaps:	339/1103 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   232 EQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTF----PAGVDTASAVVEFKRKEDTV 292
            :|.|.|..|...:.|... :|.......:|...|....|:|    |.|.:...:...||.....:
  Fly   434 KQNESYLNVGEPSGHYNV-QEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTEL 497

Human   293 VATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWP----NETSVQANGSFVR--ATV 351
            ...|:|.:|. :..||..|.|.:::.  |....:....|...|    ::..||. ||..|  .||
  Fly   498 STMLQVLNAQ-LQDSGTYVLRGSNSF--GVVQREYNVSVMDAPALKMSDAYVQV-GSVARLECTV 558

Human   352 HDYR--------------------LVLNRNLSI-SENRTMQLAVLVNDSDFQ-GPGAGVLLLH-- 392
            ..|.                    .|||:|.|: ||....|         || .|..|.|.:.
  Fly   559 RSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQ---------FQTRPRPGKLSVERI 614

Human   393 FNVSVLPVSLHLPSTYSLS-VSRRARR--------------------FAQIGKVCVEN-----CQ 431
            :.||.||....:.:..:.: :..:.||                    |.:..|:..|:     |:
  Fly   615 YEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCE 679

Human   432 A----FSGINVQYKL----------------HSSGANCSTLGVVTSAEDTSGI----LFVNDTKA 472
            |    |.| |:::.:                |:..:..||:.:.|.::...|.    .:.||..|
  Fly   680 ALAYHFDG-NLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDA 743

Human   473 LRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECE---ECGGL 534
            :...:..:|:....:..|.|:...:....:                    ||:|...   ||...
  Fly   744 VYSSREIDLYVHDPSAPQWTNGGQEGHSKI--------------------KRKLSQTLELECAST 788

Human   535 GSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEP 599
            ..|.....|.:.|.                      :|.|::..:|..::   ..::..|
  Fly   789 AVPVAIVRWFKDDK----------------------EVTESKLRHIIEKE---SKLLITH----- 823

Human   600 RGIKAGYGTCNCFPEEEKCF-CEPEDIQDPLCDELCRTVI--------AAAVLFSFIVSVLLSAF 655
                       .:|.:|..: |..|:..|.:  |...||:        .|.|.|..|:.::|...
  Fly   824 -----------LYPGDEGVYKCVVENRLDRI--ERSFTVVISDLPGISMAWVWFGVILFLILIGL 875

Human   656 CIHC---YHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW 717
            |:..   |.| .||..::      .:.|........:.|...|.| :::.|..:..:    :.::
  Fly   876 CVFLAVRYQK-EHKRHLA------LKAAGLANFEEGAVGHINPDL-TLDEQAELLPY----NREF 928

Human   718 EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV 782
            ||||:||.|||.||.|.||.|:|..|..::.....|||||||:|..|....:|.|:||..::..:
  Fly   929 EFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHL 993

Human   783 -NHPHVIKLYGACSQD---GPLLLIVEYAKYGSLRGFLRESRK-----VGP-------------- 824
             .|.:|:.|.||.:::   ..|::||||.::|:::.||..:||     :.|
  Fly   994 GQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRM 1058

Human   825 -------------------------------------------------------GYLGSGGS-- 832
                                                                   |..|||.:
  Fly  1059 SDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATY 1123

Human   833 --------------------------------RNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
                                            |::...|..:...:|..||||:|:|:::||.||
  Fly  1124 SYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYL 1188

Human   866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930
            :..|::|.||||||||:.|...:||.||||:|.:|..|:|.|...|::|:||:|:|||.||:::|
  Fly  1189 SSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFST 1253

Human   931 QSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDK 994
            .|||||:|::|||:.:|...|||||.| :.|||.|..|:|||:|...::|:|.:||:||::.|:.
  Fly  1254 YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPES 1318

Human   995 RPVFADISKDLEKMMVK--RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP------LPR- 1050
            ||:||::.|....|:.:  ...||||.......::.|   :.::.|..:....:|      .||
  Fly  1319 RPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEY---MKKQSTDYLALMGSPDELAPAAPRY 1380

Human  1051 ------------ALPSTWIENKLYGMSDPNWPGE-----SPVPLTRADGTNTGFPRYPNDSVY 1096
                        .||..::|     ||..:.|..     ||   ||.:|.::.||.:.:::.:
  Fly  1381 VNGHIVPDIRIEELPDDYME-----MSRDSDPDACTAIFSP---TRLEGESSDFPDFSSETTF 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457	6/28 (21%)
		PTKc_RET	723..1012	CDD:173631	130/403 (32%)
		Pkinase_Tyr	724..1005	CDD:285015	128/393 (33%)
		Inhibitors binding	805..807		1/1 (100%)
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	15/69 (22%)
		IG_like	672..754	CDD:214653	14/82 (17%)
		Ig	674..739	CDD:143165	10/65 (15%)
		IGc2	779..840	CDD:197706	13/101 (13%)
		PKc_like	927..1332	CDD:304357	133/404 (33%)
		Pkinase_Tyr	935..1329	CDD:285015	128/393 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810