Protein Alignment RET and CG3277

DIOPT Version :10

• Sequence 1: NP_066124.1
• Gene: RET / 5979
• HGNCID: 9967
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 799
• Identity: 199/799 - (24%)
• Similarity: 331/799 - (41%)
• Gaps: 229/799 - (28%)

Human   358 LNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLP------------------VSLHL 404
            |..|:::...:..:|.|...|:..||....||:...|.|..|                  .|::|
  Fly    85 LTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNL 149

Human   405 PSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGA----------------NCS--- 450
            |...:|:|..             .:|....|...|..:.:|.|                .||
  Fly   150 PVNPNLNVES-------------VDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQL 201

Human   451 --------TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGS 507
                    .:..:.|.|..|..|.:..::.||:.:.:.||        :|.|..:.||.:.
  Fly   202 APTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLH--------ETLRTYKMQLKIN---- 254

Human   508 YVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDV 572
               ||....|......:.|                        :||.:.....:.:..|.|...|
  Fly   255 ---EETNPSLPWGGVLKHL------------------------MTRVYKLSELNFRATPKGFEGV 292

Human   573 VE--------------TQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPE 623
            ::              .|.:.|.|..| .|          ||.:     |....|.......|.:
  Fly   293 MKLGLGTQLKEKASLSLQAVIIDPTGC-EG----------PRSV-----TKVPVPANPVLLTEGD 341

Human   624 DIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYS 688
            .:.:.:       ::.:|:|.:.|::.|:...       ...:...::|::  |:..|.:..:::
  Fly   342 SVSNSI-------IVMSAMLIAIILAGLIMLL-------LRRRRARTTAKL--RKQEQIYIQTFA 390

Human   689 SSGARRPSLDSMENQVS-VDAFKILEDPK-------WEFPRKNLVLGKTLGEGEFGKVVKATAFH 745
            :|..      .||:.|: ||  |.:|..:       :|.|...:.:|:.||||.||:|.:|||.:
  Fly   391 TSAI------EMEDNVNYVD--KYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAIN 447

Human   746 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKY 809
            |:...|.|.||||.||.|....|:.:.|:|..:||.| .|.:|:...|.|:...|.|:|:||...
  Fly   448 LRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNK 512

Human   810 GSLRGFLRESRKV-------GPGY---------LGSGGSRNSSSLD------------------- 839
            |:|..:||..||.       ...|         ..|..|..|.|::
  Fly   513 GNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDST 577

Human   840 ---------HP-----------DERA----LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880
                     ||           ||.|    |...:|.:||.||:.||::|.|.::.||||||||:
  Fly   578 AHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNV 642

Human   881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945
            |:...:.:|||||||||    ...|......::|::|::||::.:::|:::||:|::||:||||.
  Fly   643 LIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 703

Human   946 TLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 1010
            |||.:|||.|..:.|...|..|:|:|||:.|:.::|.:|||||.:||::||.|    ..|.|::.
  Fly   704 TLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLS 764

Human  1011 KRRDYLDLAASTPSDSLIY 1029
            .:..|:|:  ::.||..::
  Fly   765 PKTTYVDI--NSLSDDYVF 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	RET_CLD1	29..154	CDD:465485
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581	29..153
		Cadherin	172..261	CDD:394985
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581	265..379		4/20 (20%)
		RET_CLD3	265..379	CDD:465516	4/20 (20%)
		RET_CLD4	404..506	CDD:465517	23/128 (18%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581	405..506		22/127 (17%)
		PTKc_RET	723..1012	CDD:173631	123/348 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	122/340 (36%)