DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RET and CG3277

DIOPT Version :9

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_608762.3 Gene:CG3277 / 33543 FlyBaseID:FBgn0031518 Length:789 Species:Drosophila melanogaster


Alignment Length:799 Identity:199/799 - (24%)
Similarity:331/799 - (41%) Gaps:229/799 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   358 LNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLP------------------VSLHL 404
            |..|:::...:..:|.|...|:..||....||:...|.|..|                  .|::|
  Fly    85 LTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNL 149

Human   405 PSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGA----------------NCS--- 450
            |...:|:|..             .:|....|...|..:.:|.|                .||   
  Fly   150 PVNPNLNVES-------------VDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQL 201

Human   451 --------TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGS 507
                    .:..:.|.|..|..|.:..::.||:.:.:.||        :|.|..:.||.:.    
  Fly   202 APTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLH--------ETLRTYKMQLKIN---- 254

Human   508 YVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDV 572
               ||....|......:.|                        :||.:.....:.:..|.|...|
  Fly   255 ---EETNPSLPWGGVLKHL------------------------MTRVYKLSELNFRATPKGFEGV 292

Human   573 VE--------------TQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPE 623
            ::              .|.:.|.|..| .|          ||.:     |....|.......|.:
  Fly   293 MKLGLGTQLKEKASLSLQAVIIDPTGC-EG----------PRSV-----TKVPVPANPVLLTEGD 341

Human   624 DIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYS 688
            .:.:.:       ::.:|:|.:.|::.|:...       ...:...::|::  |:..|.:..:::
  Fly   342 SVSNSI-------IVMSAMLIAIILAGLIMLL-------LRRRRARTTAKL--RKQEQIYIQTFA 390

Human   689 SSGARRPSLDSMENQVS-VDAFKILEDPK-------WEFPRKNLVLGKTLGEGEFGKVVKATAFH 745
            :|..      .||:.|: ||  |.:|..:       :|.|...:.:|:.||||.||:|.:|||.:
  Fly   391 TSAI------EMEDNVNYVD--KYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAIN 447

Human   746 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKY 809
            |:...|.|.||||.||.|....|:.:.|:|..:||.| .|.:|:...|.|:...|.|:|:||...
  Fly   448 LRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNK 512

Human   810 GSLRGFLRESRKV-------GPGY---------LGSGGSRNSSSLD------------------- 839
            |:|..:||..||.       ...|         ..|..|..|.|::                   
  Fly   513 GNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDST 577

Human   840 ---------HP-----------DERA----LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880
                     ||           ||.|    |...:|.:||.||:.||::|.|.::.||||||||:
  Fly   578 AHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNV 642

Human   881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945
            |:...:.:|||||||||    ...|......::|::|::||::.:::|:::||:|::||:||||.
  Fly   643 LIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 703

Human   946 TLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 1010
            |||.:|||.|..:.|...|..|:|:|||:.|:.::|.:|||||.:||::||.|    ..|.|::.
  Fly   704 TLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLS 764

Human  1011 KRRDYLDLAASTPSDSLIY 1029
            .:..|:|:  ::.||..::
  Fly   765 PKTTYVDI--NSLSDDYVF 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 Cadherin 172..261 CDD:278457
PTKc_RET 723..1012 CDD:173631 123/348 (35%)
Pkinase_Tyr 724..1005 CDD:285015 121/340 (36%)
Inhibitors binding 805..807 1/1 (100%)
CG3277NP_608762.3 STYKc 426..763 CDD:214568 123/344 (36%)
PTKc 430..763 CDD:270623 122/340 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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