Protein Alignment RET and sev

DIOPT Version :10

• Sequence 1: NP_066124.1
• Gene: RET / 5979
• HGNCID: 9967
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 1244
• Identity: 274/1244 - (22%)
• Similarity: 434/1244 - (34%)
• Gaps: 411/1244 - (33%)

Human    30 YFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRL-----------GQHLYGTYRTRLHEN 83
            :..|..||.:|..               .||:....:||           |:.::.|.|.||.:
  Fly  1479 WIQRIVYWAELDA---------------TAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLK- 1527

Human    84 NWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREG-ECQW-------- 139
            :.:.:.:...|::|       .:|:.|.||..           |...:|.:| |.:|
  Fly  1528 DLVALPQAQSLIWL-------EYEQGSPRNGS-----------LRGRNLTDGSELEWATVQPLIR 1574

Human   140 -------PGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLC 197
                   ||...:  :..:.....|.....|:||   |..:.|.:.|                |.
  Fly  1575 LHAGSLEPGSETL--NLVDNQGKLCVYDVARQLC---TASALRAQLN----------------LL 1618

Human   198 PNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKY------ELVAVCTVH---------- 246
            ...|:|.:|.:..|..:.....|:....|    |.|:.:|      |.|.:...|
  Fly  1619 GEDSIAGQLAQDSGYLYAVKNWSIRAYGR----RRQQLEYTVELEPEEVRLLQAHNYQAYPPKNC 1679

Human   247 -------------AGAREEVVMVPFPVTVYDEDDSAPTFPA--------------------GVD- 277
                         ....|:..::..|:....||...| .|.                    |::
  Fly  1680 LLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLP-IPGVRYQLNLTLAKEPGSEEHDHGMEP 1743

Human   278 ------------------------TASAVVEFKRKE----DTVVATLRVFDADVVPASGELVRRY 314
                                    .:..:..|.:|:    ..|:|.|.:..|...|:.   .|.:
  Fly  1744 LGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSP---PRNF 1805

Human   315 T-----------STLLPGDTWAQQTFRVEHWPNE---TSVQANGSFVRATVHDYRLVLNRNLSIS 365
            :           |.|.|....::..:...||..|   .:||....:   ..|:.||        .
  Fly  1806 SVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREW---EAHERRL--------E 1859

Human   366 ENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSR-RARRFAQIGKVCVEN 429
            ...|.:|..:       .||:|..|.        |..|...|.|.|..| ..|.||::.::.:..
  Fly  1860 TAGTHRLTGI-------KPGSGYSLW--------VQAHATPTKSNSSERLHVRSFAELPELQLLE 1909

Human   430 CQAFSGINVQY-----KLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATD 489
            ...:| :::.:     .|.|....|.     :|||.            ||| ..|..|..:|...
  Fly  1910 LGPYS-LSLTWAGTPDPLGSLQLECR-----SSAEQ------------LRR-NVAGNHTKMVVEP 1955

Human   490 QQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTG------------RCE 542
            .|...:.|.:||:    .|.| ..|.||....::   ..|..|...|..|            |..
  Fly  1956 LQPRTRYQCRLLL----GYAA-TPGAPLYHGTAE---VYETLGDAPSQPGKPQLEHIAEEVFRVT 2012

Human   543 WRQGDGKGI--------------------TRNFSTCSPSTKTCPDGHCD-VVETQDINICPQDCL 586
            |....|.|.                    .|.......|.:..|..... |||.|.::.|....|
  Fly  2013 WTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTEL 2077

Human   587 RGSIVGGHEPG------EPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCD-----ELCRTVIA- 639
            ...:...|...      ..|.::.|:|     |..|    |.|.:.:|...     .|...:||
  Fly  2078 SCIVKSLHSSRLLLFRVRARSLEHGWG-----PYSE----ESERVAEPFVSPEKRGSLVLAIIAP 2133

Human   640 AAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPS----LDSM 700
            ||::.|.:::::|                   .....:|..:|..:...|    |||    |.::
  Fly  2134 AAIVSSCVLALVL-------------------VRKVQKRRLRAKKLLQQS----RPSIWSNLSTL 2175

Human   701 ENQVSVDAFK--------------ILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG 751
            :.|..:.|.:              :|....|    ..|.|.:.||.|.||:|.:.   .||....
  Fly  2176 QTQQQLMAVRNRAFSTTLSDADIALLPQINW----SQLKLLRFLGSGAFGEVYEG---QLKTEDS 2233

Human   752 Y--TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRG 814
            .  ..||:|.|::.|  ||..:||.|..::....|.:::.|.|.|.....:.||:|:.:.|.|..
  Fly  2234 EEPQRVAIKSLRKGA--SEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLS 2296

Human   815 FLRESRKVGPGYLGSGGSRNSSSLDHPDERA-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAAR 878
            :||.:|              ::|...|...| |::.:|::....::.|..||.:|..||||||.|
  Fly  2297 YLRAAR--------------ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACR 2347

Human   879 NILVAEG-------RKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWS 936
            |.||.|.       |.:||.||||:||:|:.|.|.|..:|.:||:||:.|||.|.::|||||||:
  Fly  2348 NCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWA 2412

Human   937 FGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA-- 999
            ||||.|||:|||..||.......:...:|.|.|:::|..|:|::|.|:|.||:.:|.:||.|.
  Fly  2413 FGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRC 2477

Human  1000 -----DISKDLEKMMVKRRDYLDLAASTPSDSLI--------------------------YDDGL 1033
                 .||.||.:..:         ||..:|:::                          .|:.|
  Fly  2478 YNTLHAISTDLRRTQM---------ASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENL 2533

Human  1034 SEEETPLVD 1042
            :..|.||.|
  Fly  2534 TLREVPLKD 2542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	RET_CLD1	29..154	CDD:465485	26/150 (17%)
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581	29..153		26/149 (17%)
		Cadherin	172..261	CDD:394985	17/117 (15%)
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581	265..379		26/176 (15%)
		RET_CLD3	265..379	CDD:465516	26/176 (15%)
		RET_CLD4	404..506	CDD:465517	24/107 (22%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581	405..506		24/106 (23%)
		PTKc_RET	723..1012	CDD:173631	112/305 (37%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	22/119 (18%)
		FN3	1993..2111	CDD:238020	22/126 (17%)
		PTKc_c-ros	2213..2483	CDD:270640	106/288 (37%)