Protein Alignment RET and Wsck

DIOPT Version :10

• Sequence 1: NP_066124.1
• Gene: RET / 5979
• HGNCID: 9967
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Alignment Length: 801
• Identity: 179/801 - (22%)
• Similarity: 301/801 - (37%)
• Gaps: 190/801 - (23%)

Human   282 VVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLL---PGDTWAQQTFRVEHWPNETSVQAN 343
            |:|.:.::|..:...|..........|..|..|.||:|   ||....:.:.:.|   |..::..|
  Fly    89 VLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTE---NSLTLSWN 150

Human   344 GSFVRATVHDYRLVL---------NRNLSISENRTMQLAVLVNDSDFQG-PGAGVLLLHFNVSVL 398
            ....|      :|:|         |:.|   :|..::..||...|.... |....::........
  Fly   151 AYEAR------KLLLAGGAEAVLPNQLL---DNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFE 206

Human   399 PVSLHLPSTYSLSVSRRARRFAQIGKVCVENC-QAF----------SGINVQYKLHSSGANCSTL 452
            ...||..:.|::|| |...:.||:|:   ..| ||.          |.:..|.|:.|......|:
  Fly   207 LTDLHPATLYNISV-RAMCKDAQVGQ---SECGQASIEATTEVGLPSPVPAQPKILSRTDRTVTI 267

Human   453 GVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY-VAEEAGCP 516
                   :.|.|.  ||...|     ::|..:|...|...|:...||||    ||: .|::.|.|
  Fly   268 -------ELSPIR--NDNGPL-----SKLLVIVEYVDNALSQPFDAQLL----GSWQQAQQDGVP 314

Human   517 LSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDV----VETQD 577
            ...|........|:     :.|.|  :..||||...|  .|..|..:  ||.|..:    |.|.:
  Fly   315 YYIAAELDYDRPED-----NRTRR--FVVGDGKRYGR--FTNKPLDQ--PDAHVHISLGLVSTLE 368

Human   578 INICPQDCLRGSIVGGHEPGEPRGI-KAGY--GTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA 639
                                   |: |..|  ||      .::.....:|......::...:|:|
  Fly   369 -----------------------GVTKTMYSRGT------HDQHVTSLDDFSYATFEKGQSSVVA 404

Human   640 AAVLFSFIVSVLLSAFCIHCYHKF------------AHKPPISSAEMTFRRP----------AQA 682
            .||......|.||.:...:.|.::            .|       |||.:.|          .:.
  Fly   405 LAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTH-------EMTLQTPIIERENNGYLVED 462

Human   683 FPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVL--GKTLGEGEFGKVVKATAFH 745
            .|:.:|      |.....:.|..|:.::       ..||..|.|  ...:|:|.||:::.... .
  Fly   463 DPLPHS------PENFKQQLQQLVEGYE-------RIPRNALRLNVNDVIGDGRFGEIITGKV-S 513

Human   746 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKY 809
            ....|...|:.|..| ::.:.:....||.|...|.|: ...|::..||..:......||.|..:.
  Fly   514 TNDFARDCTLHVLCL-DDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRM 577

Human   810 GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD 874
             ||:..|.|||.:.|.               |...:|:...::.:.::::..|.||:..::|||.
  Fly   578 -SLKRKLVESRLMAPS---------------PRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQ 626

Human   875 LAARNILVAEGRKMKISDFG------LSRDVYEEDSYVKRSQGRIPVKWMAIESL-FDHIYTTQS 932
            |.:.::.|....|:|:|.||      ::|...:.:            :|:|.|.| ..|.::|:|
  Fly   627 LCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN------------RWLAPEVLRHQHHHSTRS 679

Human   933 DVWSFGVLLWEIVTLGGNPYPG--IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 995
            ||||...:.||...|||.||..  ...::|...::...|..:|.....::|:|:|.||:.||.:|
  Fly   680 DVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSER 744

Human   996 PVFADISKDLEKMMVKRRDYL 1016
            ....|::..:.::|...|..|
  Fly   745 SSCEDVAFGVRQLMTSPRHAL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	RET_CLD1	29..154	CDD:465485
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581	29..153
		Cadherin	172..261	CDD:394985
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581	265..379		23/108 (21%)
		RET_CLD3	265..379	CDD:465516	23/108 (21%)
		RET_CLD4	404..506	CDD:465517	28/112 (25%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581	405..506		28/111 (25%)
		PTKc_RET	723..1012	CDD:173631	75/300 (25%)
Wsck	NP_733018.1	WSC	42..115	CDD:460348	4/25 (16%)
		fn3	130..222	CDD:394996	20/104 (19%)
		PTKc	497..750	CDD:270623	71/282 (25%)