DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RET and Wsck

DIOPT Version :9

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster


Alignment Length:801 Identity:179/801 - (22%)
Similarity:301/801 - (37%) Gaps:190/801 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   282 VVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLL---PGDTWAQQTFRVEHWPNETSVQAN 343
            |:|.:.::|..:...|..........|..|..|.||:|   ||....:.:.:.|   |..::..|
  Fly    89 VLEPQEQQDEQLCNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTE---NSLTLSWN 150

Human   344 GSFVRATVHDYRLVL---------NRNLSISENRTMQLAVLVNDSDFQG-PGAGVLLLHFNVSVL 398
            ....|      :|:|         |:.|   :|..::..||...|.... |....::........
  Fly   151 AYEAR------KLLLAGGAEAVLPNQLL---DNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFE 206

Human   399 PVSLHLPSTYSLSVSRRARRFAQIGKVCVENC-QAF----------SGINVQYKLHSSGANCSTL 452
            ...||..:.|::|| |...:.||:|:   ..| ||.          |.:..|.|:.|......|:
  Fly   207 LTDLHPATLYNISV-RAMCKDAQVGQ---SECGQASIEATTEVGLPSPVPAQPKILSRTDRTVTI 267

Human   453 GVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY-VAEEAGCP 516
                   :.|.|.  ||...|     ::|..:|...|...|:...||||    ||: .|::.|.|
  Fly   268 -------ELSPIR--NDNGPL-----SKLLVIVEYVDNALSQPFDAQLL----GSWQQAQQDGVP 314

Human   517 LSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDV----VETQD 577
            ...|........|:     :.|.|  :..||||...|  .|..|..:  ||.|..:    |.|.:
  Fly   315 YYIAAELDYDRPED-----NRTRR--FVVGDGKRYGR--FTNKPLDQ--PDAHVHISLGLVSTLE 368

Human   578 INICPQDCLRGSIVGGHEPGEPRGI-KAGY--GTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIA 639
                                   |: |..|  ||      .::.....:|......::...:|:|
  Fly   369 -----------------------GVTKTMYSRGT------HDQHVTSLDDFSYATFEKGQSSVVA 404

Human   640 AAVLFSFIVSVLLSAFCIHCYHKF------------AHKPPISSAEMTFRRP----------AQA 682
            .||......|.||.:...:.|.::            .|       |||.:.|          .:.
  Fly   405 LAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTH-------EMTLQTPIIERENNGYLVED 462

Human   683 FPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVL--GKTLGEGEFGKVVKATAFH 745
            .|:.:|      |.....:.|..|:.::       ..||..|.|  ...:|:|.||:::.... .
  Fly   463 DPLPHS------PENFKQQLQQLVEGYE-------RIPRNALRLNVNDVIGDGRFGEIITGKV-S 513

Human   746 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKY 809
            ....|...|:.|..| ::.:.:....||.|...|.|: ...|::..||..:......||.|..:.
  Fly   514 TNDFARDCTLHVLCL-DDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRM 577

Human   810 GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD 874
             ||:..|.|||.:.|.               |...:|:...::.:.::::..|.||:..::|||.
  Fly   578 -SLKRKLVESRLMAPS---------------PRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQ 626

Human   875 LAARNILVAEGRKMKISDFG------LSRDVYEEDSYVKRSQGRIPVKWMAIESL-FDHIYTTQS 932
            |.:.::.|....|:|:|.||      ::|...:.:            :|:|.|.| ..|.::|:|
  Fly   627 LCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN------------RWLAPEVLRHQHHHSTRS 679

Human   933 DVWSFGVLLWEIVTLGGNPYPG--IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 995
            ||||...:.||...|||.||..  ...::|...::...|..:|.....::|:|:|.||:.||.:|
  Fly   680 DVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSER 744

Human   996 PVFADISKDLEKMMVKRRDYL 1016
            ....|::..:.::|...|..|
  Fly   745 SSCEDVAFGVRQLMTSPRHAL 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 Cadherin 172..261 CDD:278457
PTKc_RET 723..1012 CDD:173631 75/300 (25%)
Pkinase_Tyr 724..1005 CDD:285015 74/292 (25%)
Inhibitors binding 805..807 1/1 (100%)
WsckNP_733018.1 WSC 42..115 CDD:280068 4/25 (16%)
fn3 130..222 CDD:278470 20/104 (19%)
TyrKc 493..746 CDD:197581 72/282 (26%)
PTKc 497..750 CDD:270623 71/282 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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