DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and ret

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	1116	Identity:	661/1116 - (59%)
Similarity:	817/1116 - (73%)	Gaps:	38/1116 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    17 LLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLH 81
            :||.||.:.:.||||.:..|.|.:||.|..|:|||.|.::|:.|.|.|.|.|..|       |..
Zfish    11 VLLLLLSEGSFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSH-------RDA 68

Human    82 ENNWICIQEDTGLLYLNRSLDHSSWEKL---SVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCA 143
            ..:|..|.|.:|:||||::|:.|.:..|   |||:.    ..:.|||.:|.|...:..|......
Zfish    69 FTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSP----KDLTLKVGVSSTPPMKVMCTILPTV 129

Human   144 RVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLE 208
            .|..||.|.:.|:|..::...|||||...:..|.|||.||...|.|......:|||.:::|.::.
Zfish   130 EVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGALRQLRRFTHMSICPNYTISYGVVA 194

Human   209 GEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFP 273
            |..:||.....:.|:.....:|||::|.|.|..||.|......|.|.....|.:|||||::| :.
Zfish   195 GSSVPFAVDDSTSELVVTAQVDREEKEVYHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSP-YV 258

Human   274 AGVDTASAVVEFKRKEDTVVATLRVFDADVVPA--SGELVRRYTSTLLPGDTWAQQTFRVEH-WP 335
            .|.||...:|||.|.|.||..||.|:|.|..|.  :.::..:...||:..|:|.:..|.:|| :.
Zfish   259 NGTDTEDVLVEFDRSEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFR 323

Human   336 NETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV 400
            .|.::..|   ||.|||:|:|.|::|||::|.|:..|..||||:.|.|| .|.:||||||:||||
Zfish   324 EEKAIFGN---VRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGP-EGTVLLHFNVTVLPV 384

Human   401 SLHLPS-TYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS--------TLGVVT 456
            .:...: |||.:||::|..::|||||||||||.|.||:|.|:|.....|.:        .:.:..
Zfish   385 PIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQ 449

Human   457 SAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEG---SYVAEEAGCPLS 518
            :..|.:|:|:|||||.||||:|.||.|:|:|.:||...||:.||.|:.:|   |...:|...| :
Zfish   450 NPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFP-A 513

Human   519 CAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQ 583
            ||..::|.:||...|||:|||||:||||..|||::.:|||||:..|||||:||.:|:::|:||||
Zfish   514 CAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDGYCDAIESKNISICPQ 578

Human   584 DCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIV 648
            ||...:|:||:| .:..|||||:|||.||  |.|||||.::.:|.:|:::|:||||..::.||||
Zfish   579 DCSSEAIIGGYE-RDLYGIKAGHGTCYCF--EGKCFCERDEPEDDICNDMCKTVIATGIILSFIV 640

Human   649 SVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713
            |||||::.||.|||...||||:|||||||||||::|:|||::..||.|||||||||::|.|||.|
Zfish   641 SVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAIDTFKIPE 705

Human   714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV 778
            |||||||||||||||||||||||||||||||.|||:||||||||||||||||.||||||||||.:
Zfish   706 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTL 770

Human   779 LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 843
            |||||||||||:||||||||||.||||||||||||.||||||||||.|:|:..:||||.|::|||
Zfish   771 LKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDE 835

Human   844 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 908
            ||||||||||||||||:|||||||||||||||||||:||||||||||||||||||||||||||||
Zfish   836 RALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKR 900

Human   909 SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERP 973
            |:|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||:|||:|
Zfish   901 SKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKP 965

Human   974 DNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEET 1038
            :||::|||.|||:|||||.||||.|:||||:|||||||.|||||||||||:|:|:|||.||||:|
Zfish   966 ENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDT 1030

Human  1039 PLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSP 1103
            |||||:||||||.||||||||||||||.||||.:|||||.|.|.||..|.||.|||||||||...
Zfish  1031 PLVDCSNAPLPRTLPSTWIENKLYGMSYPNWPEKSPVPLNRLDATNPVFTRYANDSVYANWMALH 1095

Human  1104 SAAKLMDTFDS 1114
            |.||::||.||
Zfish  1096 SPAKIVDTIDS 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457	27/88 (31%)
		PTKc_RET	723..1012	CDD:173631	256/288 (89%)
		Pkinase_Tyr	724..1005	CDD:285015	249/280 (89%)
		Inhibitors binding	805..807		1/1 (100%)
ret	NP_858048.2	CA	186..256	CDD:214520	22/69 (32%)
		PTKc_RET	715..1004	CDD:173631	256/288 (89%)
		Pkinase_Tyr	716..997	CDD:285015	249/280 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329656
Domainoid	1	1.000	514	1.000	Domainoid score	I2571
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7517
Inparanoid	1	1.050	1290	1.000	Inparanoid score	I1369
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39089
OrthoDB	1	1.010	-	-		D153428at2759
OrthoFinder	1	1.000	-	-		FOG0008389
OrthoInspector	1	1.000	-	-		oto43055
orthoMCL	1	0.900	-	-		OOG6_108073
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4355
SonicParanoid	1	1.000	-	-		X6379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300