DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and Ret

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_036775.2	Gene:	Ret / 24716	RGDID:	3556	Length:	1115	Species:	Rattus norvegicus

Alignment Length:	1115	Identity:	951/1115 - (85%)
Similarity:	1018/1115 - (91%)	Gaps:	1/1115 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPS 65
            ||||.||||||.|.|.|||||||:..||||||||||||:|||||.|||||||||||||||.||||
  Rat     1 MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPS 65

Human    66 FRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPT 130
            |||||:|||.||||||||:||.|...|||||||:||||||||:||:||.|||||||:|:|||..|
  Rat    66 FRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGST 130

Human   131 SLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQF 195
            :.|||||.|||||||||||.|.:||.|||.|.|:||.|||..|||||||||||||:|||:|||||
  Rat   131 AQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQF 195

Human   196 LCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHA-GAREEVVMVPFP 259
            |||||||.|:||||:||||||.||.||||||||||||.:|||.|.|.|.|.. ||.:|.|.|.||
  Rat   196 LCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFP 260

Human   260 VTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTW 324
            |||||||||.|||..||.||||||||||||.||||||:||||||||||||||||||||||.||:|
  Rat   261 VTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSW 325

Human   325 AQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVL 389
            |||||||||.||||.||:|.:.||||:|:|:|||||:|||||:|.:||.||||||||||||:|||
  Rat   326 AQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVL 390

Human   390 LLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGV 454
            .||||||||||:|:||..||..|:|||||:||||||||||||.|||:::||||..|..|||.|||
  Rat   391 FLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGV 455

Human   455 VTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSC 519
            |||.|||||.|:||||:|||||:|.||.|.|||||:||.||.||.|:|||||:|:|||.|||.||
  Rat   456 VTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSC 520

Human   520 AVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQD 584
            ||:|||.||||||||||||||||||||||||||||||||||||:||||||||.:|::||||||||
  Rat   521 AVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQD 585

Human   585 CLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVS 649
            ||||.||||||.||.:|||||||.|||||:|:||||||||.|.|||||||||||.||||||||:|
  Rat   586 CLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIIS 650

Human   650 VLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILED 714
            ||||.||||.|||.||||||:||||||.||||.||:||||||.|||||||||||||||:|||.||
  Rat   651 VLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPED 715

Human   715 PKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL 779
            ||||||||||||||||||||||||||||||.||||||||||||||||||||.|||||||||||:|
  Rat   716 PKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLL 780

Human   780 KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER 844
            ||||||||||||||||||||||||||||||||||||||:|||:||.|:.||||||||||||||||
  Rat   781 KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDER 845

Human   845 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS 909
            .||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat   846 VLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKS 910

Human   910 QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD 974
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   911 KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD 975

Human   975 NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETP 1039
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||:|||||||||||
  Rat   976 NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETP 1040

Human  1040 LVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPS 1104
            |||||:|||||:||||||||||||||||||||||||||||||||:||||||.|||||||||:|||
  Rat  1041 LVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPS 1105

Human  1105 AAKLMDTFDS 1114
            ||||||||||
  Rat  1106 AAKLMDTFDS 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457	67/89 (75%)
		PTKc_RET	723..1012	CDD:173631	276/288 (96%)
		Pkinase_Tyr	724..1005	CDD:285015	268/280 (96%)
		Inhibitors binding	805..807		1/1 (100%)
Ret	NP_036775.2	Cadherin	173..248	CDD:278457	60/74 (81%)
		PTKc_RET	724..1013	CDD:173631	276/288 (96%)
		Pkinase_Tyr	725..1006	CDD:285015	268/280 (96%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83682145
Domainoid	1	1.000	552	1.000	Domainoid score	I5809
eggNOG	1	0.900	-	-		E1_KOG0200
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7517
Inparanoid	1	1.050	1963	1.000	Inparanoid score	I1527
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39089
OrthoDB	1	1.010	-	-		D153428at2759
OrthoFinder	1	1.000	-	-		FOG0008389
OrthoInspector	1	1.000	-	-		oto132808
orthoMCL	1	0.900	-	-		OOG6_108073
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6379
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270