DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and Ret

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_033076.2	Gene:	Ret / 19713	MGIID:	97902	Length:	1115	Species:	Mus musculus

Alignment Length:	1116	Identity:	929/1116 - (83%)
Similarity:	1005/1116 - (90%)	Gaps:	3/1116 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPS 65
            |||||||||||.|.|:|||||||:..||||||||||||:|||||.|||||||||||||||.||||
Mouse     1 MAKATSGAAGLGLKLILLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPS 65

Human    66 FRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPT 130
            |||||||||.||||||||:||.|.|.|||||||:||||||||:||:||.||||||::|:|||..|
Mouse    66 FRLGQHLYGVYRTRLHENDWIRINETTGLLYLNQSLDHSSWEQLSIRNGGFPLLTIFLQVFLGST 130

Human   131 SLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQF 195
            :.|||||.||||.||||||.|.:||.|||.|.::||.|||..|||:|||||||||:.|.:|||||
Mouse   131 AQREGECHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPETAVSFRVRENRPPGTFYHFHMLPVQF 195

Human   196 LCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHA-GAREEVVMVPFP 259
            |||||||.|.||.|:.|||||.||.||||||||||||.||||.|.|:|.|.. ||.:|.|.:.||
Mouse   196 LCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALDRELREKYVLEALCIVAGPGANKETVTLSFP 260

Human   260 VTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTW 324
            |||||||||||||..||.||||||||||||.||||||:||||||||||||||||||:|||.||:|
Mouse   261 VTVYDEDDSAPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTNTLLSGDSW 325

Human   325 AQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGA-GV 388
            |||||||||.|.||.||.|.:.||||:|:|:|:|||:|||||:|.:|||||||||||||||| |:
Mouse   326 AQQTFRVEHSPIETLVQVNNNSVRATMHNYKLILNRSLSISESRVLQLAVLVNDSDFQGPGAGGI 390

Human   389 LLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLG 453
            |:||||||||||:|:||..||..|::||||:||||||||||||.|||:::||||..|..||:.||
Mouse   391 LVLHFNVSVLPVTLNLPRAYSFPVNKRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSINCTALG 455

Human   454 VVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLS 518
            ||||.|||||.||||||:|||||:|.:|.|.|||||:||.||.||.|:|||||:.:.||.|||.|
Mouse   456 VVTSPEDTSGTLFVNDTEALRRPECTKLQYTVVATDRQTRRQTQASLVVTVEGTSITEEVGCPKS 520

Human   519 CAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQ 583
            |||:|||.||||||||||||||||||||||||||||||||||||:||||||||.||::|.|||||
Mouse   521 CAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDAVESRDANICPQ 585

Human   584 DCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIV 648
            ||||..||||||.||.:|||||||.|||||:|:||||||||.|.||||.||||:|.|| |||.|:
Mouse   586 DCLRADIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDALCRTIITAA-LFSLII 649

Human   649 SVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713
            |:|||.||:..:||..|||||:||||||.||||.||:||||||.|||||||.||||.||:|||.|
Mouse   650 SILLSIFCVCHHHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVPVDSFKIPE 714

Human   714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV 778
            |||||||||||||||||||||||||||||||.||||||||||||||||||||.|||||||||||:
Mouse   715 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNL 779

Human   779 LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 843
            |||||||||||||||||||||||||||||||||||||||:|||:||.|:..||||||||||||||
Mouse   780 LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSLDHPDE 844

Human   844 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 908
            |.||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   845 RVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKK 909

Human   909 SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERP 973
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   910 SKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERP 974

Human   974 DNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEET 1038
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||||:||||||||||
Mouse   975 DNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEET 1039

Human  1039 PLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSP 1103
            ||||||||||||:||||||||||||||||||||||||||||||||:||||||.|||||||||:||
Mouse  1040 PLVDCNNAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSP 1104

Human  1104 SAAKLMDTFDS 1114
            |||||||||||
Mouse  1105 SAAKLMDTFDS 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457	62/89 (70%)
		PTKc_RET	723..1012	CDD:173631	275/288 (95%)
		Pkinase_Tyr	724..1005	CDD:285015	267/280 (95%)
		Inhibitors binding	805..807		1/1 (100%)
Ret	NP_033076.2	Cadherin	173..262	CDD:278457	62/88 (70%)
		PTKc_RET	724..1013	CDD:173631	275/288 (95%)
		Pkinase_Tyr	725..1006	CDD:285015	267/280 (95%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83956585
Domainoid	1	1.000	550	1.000	Domainoid score	I6214
eggNOG	1	0.900	-	-		E1_KOG0200
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7517
Inparanoid	1	1.050	1918	1.000	Inparanoid score	I1775
Isobase	1	0.950	-	0	Normalized mean entropy	S4510
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39089
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008389
OrthoInspector	1	1.000	-	-		oto116397
orthoMCL	1	0.900	-	-		OOG6_108073
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4355
SonicParanoid	1	1.000	-	-		X6379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240