DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RET and R09D1.13

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_496022.1	Gene:	R09D1.13 / 187740	WormBaseID:	WBGene00011169	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	110/397 - (27%)
Similarity:	183/397 - (46%)	Gaps:	80/397 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   642 VLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSV 706
            :|....::|:|.||.  |..:..:|      :.|..|||           .||....|:..|:.:
Worm     7 ILICIFIAVILFAFA--CILQKVYK------KKTQDRPA-----------LRRGKRGSITEQIEL 52

Human   707 -----------DAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML 760
                       |...|...|. |....||.....|..|.|.|:          |.|  |:.:.:.
Worm    53 TPINKDDMCIRDNISIGNIPV-EIDPSNLKFSSVLENGYFCKI----------RRG--TLNINVT 104

Human   761 KENASPSELRDLL--------------SEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKY 809
            .|..:.::|.|:|              :|..:|:.: .||:|:.|.|..| ..|..:::.|..:.
Worm   105 AEEKNSNKLVDVLVKRPKNHIEKEMLENELTILRLIGRHPNVLALIGYTSPMFGRTVVVYESVEL 169

Human   810 GSLRGFLRESRK----VG-PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK 869
            |:|:..|:.::.    || |       ....|.||.     ..:.||.|||:||:.||:||..:.
Worm   170 GNLQHVLKITKNNFELVGVP-------ETEFSGLDE-----FCVSDLHSFAFQIANGMEYLTHIP 222

Human   870 LVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDV 934
            ::||.||.|||.:...:.::|::||||::| .:...:......:|:.|||.||..:.|:..::||
Worm   223 VIHRFLALRNIFLKRNKTIRIANFGLSKNV-NDYRIIDSMDTPVPLYWMAPESYNELIFNEKTDV 286

Human   935 WSFGVLLWEIVTLGGNPYPGIPP--ERLFNLLKTGHRMERPDNC-SEEMYRLMLQCWKQEPDKRP 996
            |||||.|:|:.:||.:||..:..  :.|...|:.|:|:.:|... |.|::..|..||..:|:.||
Worm   287 WSFGVCLYELYSLGEDPYENVKTLFDHLMEYLEKGNRLSKPKYIDSPEIFDFMKICWNFKPETRP 351

Human   997 VFADISK 1003
            .|:|.::
Worm   352 CFSDCAQ 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	91/305 (30%)
		Pkinase_Tyr	724..1005	CDD:285015	90/304 (30%)
		Inhibitors binding	805..807		1/1 (100%)
R09D1.13	NP_496022.1	STYKc	80..360	CDD:214568	90/304 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810