DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RET and ver-3

DIOPT Version :9

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_509836.1 Gene:ver-3 / 181289 WormBaseID:WBGene00006896 Length:1227 Species:Caenorhabditis elegans


Alignment Length:1245 Identity:257/1245 - (20%)
Similarity:430/1245 - (34%) Gaps:406/1245 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    66 FRLGQHLYGTYRTRLHENNWIC---IQEDTGLLYL----NRSLD---HSSWEKLSVRNRGFP--- 117
            |::.:.||.  ..::.:.|:.|   .:|:....|:    ..|.|   |.||||      ||.   
 Worm   185 FKITKKLYS--EKQIVDVNFECRYKKEENQTATYIITEKEASSDDGYHFSWEK------GFQWPH 241

Human   118 -----LLTVYL-----KVFLSPTSLREGECQWPGCA------------RVYFSFFNTS------- 153
                 .||..|     |:|...|:....||  |.|:            |:..:..:|:       
 Worm   242 VGYNFSLTCNLNYNGSKIFHGYTNKLSIEC--PQCSHDPGSHVHVDRHRIIGNKISTTVRIQHLE 304

Human   154 ----------------------FPACSSLKPRELCFPETRPS-FRIRENRPPGTFHQFRLLPVQF 195
                                  :....:.|..::...||.|: .||:|||......:|.:.|.: 
 Worm   305 LEDSGKYTCIWEHENKETKYTDYHLYVAPKKAQIKVIETSPTIMRIKENRATSLTAKFAIYPFE- 368

Human   196 LCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPV 260
                                              ......|:..:...::|.|.:.|.::     
 Worm   369 ----------------------------------KESYTAKWSRIYNSSIHEGPQSETII----- 394

Human   261 TVYDEDD----SAPTFPAG---------------------------VDTASAV---VEFKRKEDT 291
                .||    :|.:|..|                           :||...|   |..:..|..
 Worm   395 ----NDDFRKIAATSFGDGAFSENLDIKAFAVSTNMSGTYVLSISHMDTVQVVQWEVAIENDEPD 455

Human   292 VVATLRVFDADVV-------PASGELVRRYTSTLLPGD------TWAQQTFRVEHWPNETSVQAN 343
            |..|:|...:..:       |.:...:...:.::.|.|      |...:.|: |..||:. |...
 Worm   456 VQITVREPSSFFISNQEYYKPDTNLHIECISISIPPADVVFEYKTKNSEQFQ-EIEPNKL-VSVG 518

Human   344 GSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVS------------ 396
            |:|.|..:::.......:|..|..|....|:.||.....|.|..|...|...|            
 Worm   519 GTFDRGLIYNVTFTEGMDLKCSSIRKGNRAITVNKLIKIGEGFEVRPHHEKSSKATESEPSKIIY 583

Human   397 ---------VLP-------VSLHLPSTYSLSVS----RRARRFAQIGKVCVENCQ----AFSGIN 437
                     |.|       ||....::.|..:|    .......|..|..:.|.:    :|:|  
 Worm   584 EGDNVKLTCVFPLDSDDWSVSWRFENSKSSDISSIPTTTETEIKQYSKHLILNLRDVTTSFTG-- 646

Human   438 VQYKLHSSGANCSTLGVVTSAEDTSGILFVN-DTKALRRPKCAELHYMVVATDQQTSRQAQAQLL 501
                         |...|...||:..:|..: |.||:.:|..             |...:.|.::
 Worm   647 -------------TYTCVVKNEDSEKLLETSIDVKAISKPSI-------------TGGNSNAVVI 685

Human   502 VTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCP 566
            |..:..:   |..|.::                |:|....:|           |...:|.|....
 Worm   686 VDYDQYF---EINCNMT----------------GTPPPVYQW-----------FKDGNPYTHGDV 720

Human   567 DGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGI---KAGYGTCNCFPEEEKCFCEPEDIQDP 628
            ||               ..||.|...|.:.||...:   :||          :|.......:.:.
 Worm   721 DG---------------SILRVSRARGEDDGEFHCLATNRAG----------DKLNSIEVQVNNA 760

Human   629 LCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPI---SSAEMTFRRPAQAFPVSYSSS 690
            ....|......|.:|...|::|.|....:...::...:..|   :..|...:..|...|      
 Worm   761 PKGSLFFYWFLALLLLISIIAVFLLTCKLRASNRLTKQKDIALNTLYETMIKHQAGPLP------ 819

Human   691 GARRPSLDSMEN-QVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT 754
                   :.|:: .|....:.:..:..:|....||.:...:|.|.|| |||      ||..|...
 Worm   820 -------EEMKDLPVEERTYYLPYNNDYEIDPVNLEILNPIGSGHFG-VVK------KGLLGMAY 870

Human   755 VAVKMLKENASPSELRDLLSEFNV---------LKQV----NHPHVIKLYGACSQD---GPLLLI 803
            ...|:..:...|..::...:.|||         ||.:    .:|:|:.|.||.:::   |.|.::
 Worm   871 PKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIV 935

Human   804 VEYAKYGSLRGFLRESRK-------------VGPGYLGSG-------------GSRNSSSLDHPD 842
            .|:...|:||.||:..|.             |...||...             |......::.||
 Worm   936 TEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPD 1000

Human   843 ERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-V 906
              ||...||:|...||::||.:||::..||||||.||:|:.:.:.::|:|||||:....:..| .
 Worm  1001 --ALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRT 1063

Human   907 KRSQGR-IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM 970
            |:|:.. :||:||.:|.:.:..:|.:|||||||:.|:||.||||.|||......:...::.|:|.
 Worm  1064 KKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFIRNGNRN 1128

Human   971 ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRD----YLDLAASTPSDSLIYDD 1031
            ::|:.|.:|:|.||..||:..|..||.|.|.....|..|   ||    :|:..     :::::.:
 Worm  1129 KQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFENHM---RDSSSQFLERV-----ENMLHTE 1185

Human  1032 GLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVY 1096
              .:|::.|.|             ||::                  :|.|..|..|.:.|.....
 Worm  1186 --MQEQSKLDD-------------WIQD------------------SRPDVPNVSFQKSPKKQKE 1217

Human  1097 ANWMLSPSAA 1106
            ..:::..|.|
 Worm  1218 ERYLIVESHA 1227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 Cadherin 172..261 CDD:278457 12/89 (13%)
PTKc_RET 723..1012 CDD:173631 108/332 (33%)
Pkinase_Tyr 724..1005 CDD:285015 105/324 (32%)
Inhibitors binding 805..807 1/1 (100%)
ver-3NP_509836.1 IG 242..>313 CDD:214652 12/72 (17%)
IG_like 578..667 CDD:214653 16/103 (16%)
Ig_3 578..654 CDD:290638 13/90 (14%)
I-set 673..757 CDD:254352 23/151 (15%)
IGc2 692..747 CDD:197706 16/99 (16%)
STYKc 847..1163 CDD:214568 105/324 (32%)
PTKc 851..1164 CDD:270623 104/321 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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