DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and kin-30

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_506771.3	Gene:	kin-30 / 180032	WormBaseID:	WBGene00002211	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	130/444 - (29%)
Similarity:	206/444 - (46%)	Gaps:	54/444 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   612 FPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTF 676
            ||.....|....:..|.  .|....:|...:...||..||...|...|:.:..::   |||....
Worm     5 FPNRFARFVRSVENHDE--SEKPNLIIVFLMCALFIYGVLSIIFVTICFLRRIYR---SSATKNG 64

Human   677 RR---------PAQAFPVSYSSSGARRPSLDSM----ENQVSVDAFKILE-------DPKWEFPR 721
            .|         .||....|.||....:..::::    |..:..|...:.|       :|.:|...
Worm    65 NRRYLVQNTYVKAQLDTNSSSSLPVDKEIIETISINEETPIITDYQPLNERAEYLPYNPAFEIHS 129

Human   722 KNL-VLGKTLGEGEFGKVVKATAFHLKGRAGYTT---VAVKMLKENASPSELRDLLSEFNVLKQV 782
            ::| |..|..|:|.||||.||....:..:.|...   ||||...::...|:.:.:|.|..::..:
Worm   130 EHLDVFEKQFGQGNFGKVNKALLKLINQKTGEVVRMDVAVKKPADSTDKSQDKLILDEIKLMCAI 194

Human   783 -NHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYLGS----GGSR-NS 835
             .||:|:.:.||.::...:      |::.|:.:.|.||..|:.:.......|.|    ||.. ||
Worm   195 GKHPNVLAIVGAITKQEKVIGREHNLVVTEFVEGGDLRSVLKYTPYTFHDELTSTDRTGGQMVNS 259

Human   836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900
            ...|.     |:..||.|||:||:.||:|||....||||||.||:.|...:.::|.||||:|. :
Worm   260 DIFDE-----LSTSDLYSFAYQIANGMEYLAAKPCVHRDLALRNVFVKRNKMIRIGDFGLARH-H 318

Human   901 EEDSYVK---RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI---PPER 959
            .:.||.:   .....:|:.|:|.|...:..:|..:||||:||.|:|:.:||.:||..:   |...
Worm   319 SKKSYYRMQCNPDTPLPIFWLAPECFNESKFTEMTDVWSYGVCLFELFSLGESPYKKLHNSPSYD 383

Human   960 LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR 1013
            :.:.||.|:|:..|..|:.|:|..||.||..:...||.|.: .||..|.::.|:
Worm   384 VVHYLKKGYRLSAPRYCNAEIYEFMLYCWNIDATLRPKFTE-CKDFCKSLITRK 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	103/310 (33%)
		Pkinase_Tyr	724..1005	CDD:285015	101/302 (33%)
		Inhibitors binding	805..807		1/1 (100%)
kin-30	NP_506771.3	TyrKc	134..428	CDD:197581	100/300 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810