DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RET and W04G5.10

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_492969.2	Gene:	W04G5.10 / 173049	WormBaseID:	WBGene00012270	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	115/389 - (29%)
Similarity:	189/389 - (48%)	Gaps:	58/389 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   643 LFSFIVSVL----LSAFCIHCYHKF---AHKPPISSAEMTFRRP--AQAFPVSYSSSGARRPSLD 698
            :|.:|:.||    ||.|.::.:.:.   :....:..:|....|.  ..:.|:| :.....|..:.
Worm     9 IFIYIIFVLLFLALSLFLLYIWRRILTNSSNSDLGGSEEDVERSLLTTSLPIS-NKYDLDRTRIQ 72

Human   699 SMENQVSVDAFKILEDPKWEFPRKNLVLG--KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK 761
            :....:|.....::.|...|...:||.:.  ..:|.|.||.|.:|.....:..:.:..||||
Worm    73 TESELISETIKSLIGDNHLEIDPENLKISTENYIGSGFFGTVYRAELRRERRNSNFMIVAVK--- 134

Human   762 ENASPSELRD------LLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES 819
               .||.:.:      |..|.||: ....||:::.|.|..:|.. ::::.||.:.|.|..|||:.
Worm   135 ---EPSNIHNIRQKKILHEELNVMCSMEKHPNILSLVGVVTQRN-VMIVTEYVEDGDLLKFLRKC 195

Human   820 RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE 884
            :          ..::|..|   ||::|...||.||.:||:.|||||..:..||||||.||:|:..
Worm   196 K----------FDKDSVKL---DEKSLCKADLFSFTFQIANGMQYLERVPCVHRDLALRNVLIKN 247

Human   885 GRKMKISDFGLSRDVYEEDSY-VKRSQGRIPVKWMAIESL--------FDHIYTTQSDVWSFGVL 940
            ...:||:||||:|...::|.| .|.:...:|:||:|.|..        ||    ::|||||:||.
Worm   248 NGVLKIADFGLARRHDKKDYYRTKTTDTALPIKWLAPECFEEEEEKIRFD----SKSDVWSYGVC 308

Human   941 LWEIVTLGGNPYPGIPPER------LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF 998
            |:||.:||.:||..:....      |.:.|:.|:.:..|::|:.:||..|..||...|::||.|
Worm   309 LYEIFSLGESPYNELDSNNFAFLQVLADFLRKGNTLSEPEHCAPKMYYFMKSCWNLIPEERPSF 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	100/300 (33%)
		Pkinase_Tyr	724..1005	CDD:285015	99/299 (33%)
		Inhibitors binding	805..807		1/1 (100%)
W04G5.10	NP_492969.2	PTKc	104..378	CDD:270623	98/293 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810