DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RET and ret

DIOPT Version :9

Sequence 1:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens
Sequence 2:	XP_012822323.2	Gene:	ret / 100495902	XenbaseID:	XB-GENE-485176	Length:	1102	Species:	Xenopus tropicalis

Alignment Length:	1112	Identity:	691/1112 - (62%)
Similarity:	830/1112 - (74%)	Gaps:	19/1112 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     9 AGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLY 73
            ||..|.||.||    :||.||||....|.|.|||||.|||.||::|.::|:|.|.|.|||..:
Frog     4 AGWALCLLSLL----QVASGLYFLTKDYDENLYVDQPAGTLLLHIHVMKDSPHETPHFRLCPN-- 62

Human    74 GTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQ 138
             :|.:|:...:|..|.|.||:||||||||.|.:| :..:.....:..:.|||...|....:..|.
Frog    63 -SYLSRISFYHWFWIDEHTGILYLNRSLDRSDYE-VFAQGSSLAVQKIILKVSTKPQPFLDNNCD 125

Human   139 WPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVA 203
            .....||:.:|.|.:...||||||::|||.:...||.|:||:|||..::|...|:...|||:||:
Frog   126 NAPFTRVHLTFRNITSSICSSLKPKDLCFNDKDLSFHIKENKPPGKLYKFHPRPIVQSCPNVSVS 190

Human   204 YRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDS 268
            |.|:.....|||..|::.|||....:|||:||.|:|||.|.:.....|..|...|.:.|.||||:
Frog   191 YMLISDHSYPFRFNPNTSEVSLTHTMDREERENYDLVAKCLLRDSTSEVEVEKSFQIKVDDEDDT 255

Human   269 APTFPAGVDTASAVVEFKRKEDTVVATLRVFDAD---VVPASGELVRRYTSTLLPGDTWAQQTFR 330
            ||..|.|.|||:.|||||||..||:..|.|:|||   |.||.... ::|..|::..|.:..:.||
Frog   256 APFLPNGTDTANVVVEFKRKNGTVLGMLTVWDADSTPVYPAEASF-KKYAKTIVNNDRFILENFR 319

Human   331 VEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNV 395
            |||...|...|..|:.:|.|:|:||||||:.:.|:.|.::.::|||||::|.||. |.::|:|||
Frog   320 VEHSFREVKFQPKGNLIRGTLHEYRLVLNKTMPITRNGSLLVSVLVNDTEFHGPN-GDVMLYFNV 383

Human   396 SVLPVSLHLPS-TYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAE 459
            ::|||.:..|: :|..:|:|.|.|:|||.|:|:|||:.|.|:||.|:|.:.. |.....::...|
Frog   384 TILPVEIRFPNISYQYTVNRNADRYAQIEKICIENCKLFEGVNVNYRLQTDN-NTRAFSIIQGRE 447

Human   460 DTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKR 524
            .|...|.|||:.||...:..|:...|.||::......:.|:::.:||:.:..|..||.||:.||:
Frog   448 STFATLIVNDSDALATHESKEVVCTVFATNKHLKEPVKTQIIIVLEGTPLKNEDNCPRSCSESKQ 512

Human   525 RLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRG- 588
            :.||||||||||.||||:||||.|:|||.|:|||:||..|||||.||.||:.:..||||||...
Frog   513 KSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPDGVCDAVESNNSTICPQDCTTEI 577

Human   589 SIVGGHEPGEPRGIKAGYGTCNC-FPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLL 652
            :|:||||.|...|||||||||.| .|  :|||||...::.||||:.|:||||..|..|||:||||
Frog   578 TIIGGHEKGALSGIKAGYGTCFCLLP--DKCFCEKNIVEGPLCDDTCKTVIACGVFLSFIISVLL 640

Human   653 SAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW 717
            |::.||.|||.:.||||:|||||||||||::||||||:.||||||||||||||||.|||.|||||
Frog   641 SSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPVSYSSNNARRPSLDSMENQVSVDTFKIPEDPKW 705

Human   718 EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV 782
            |||||||||||||||||||||||||||.|||:|||||||||||||:||.|||||||||||:||||
Frog   706 EFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKESASQSELRDLLSEFNLLKQV 770

Human   783 NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALT 847
            ||||||||||||:|||||.||||||||||||.||||||||||..||...:||||.||:|||||||
Frog   771 NHPHVIKLYGACTQDGPLHLIVEYAKYGSLRSFLRESRKVGPSSLGGDSNRNSSYLDNPDERALT 835

Human   848 MGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR 912
            ||||||||||||:|||||||||||||||||||:|||||||||||||||||||||||||||||:||
Frog   836 MGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGR 900

Human   913 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS 977
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||:|||:|:|||
Frog   901 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCS 965

Human   978 EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVD 1042
            :|||.|||:||||||||||.|.:|||:|||||||.|||||||||||:|||:||||||||||||||
Frog   966 DEMYNLMLKCWKQEPDKRPTFGEISKELEKMMVKSRDYLDLAASTPADSLLYDDGLSEEETPLVD 1030

Human  1043 CNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAK 1107
            ||||||||.||||||||||||||.|||..|||||:.|.|...:.|.||.||.||||||:.||.||
Frog  1031 CNNAPLPRTLPSTWIENKLYGMSYPNWSEESPVPIPRFDANKSVFSRYANDCVYANWMIPPSTAK 1095

Human  1108 LMDTFDS 1114
            .|:.|||
Frog  1096 FMEKFDS 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	Cadherin	172..261	CDD:278457	37/88 (42%)
		PTKc_RET	723..1012	CDD:173631	258/288 (90%)
		Pkinase_Tyr	724..1005	CDD:285015	251/280 (90%)
		Inhibitors binding	805..807		1/1 (100%)
ret	XP_012822323.2	RET_CLD1	20..141	CDD:407628	49/124 (40%)
		Cadherin	160..242	CDD:421759	35/81 (43%)
		RET_CLD3	252..368	CDD:407681	53/116 (46%)
		RET_CLD4	392..494	CDD:407682	34/102 (33%)
		PTKc_RET	711..1000	CDD:173631	258/288 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	515	1.000	Domainoid score	I3495
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7517
Inparanoid	1	1.050	1377	1.000	Inparanoid score	I1708
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39089
OrthoDB	1	1.010	-	-		D153428at2759
OrthoFinder	1	1.000	-	-		FOG0008389
OrthoInspector	1	1.000	-	-		oto150896
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080