Protein Alignment DPF2 and dpff-1

DIOPT Version :9

• Sequence 1: XP_024304405.1
• Gene: DPF2 / 5977
• HGNCID: 9964
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_498281.2
• Gene: dpff-1 / 175832
• WormBaseID: WBGene00016200
• Length: 372
• Species: Caenorhabditis elegans
• Alignment Length: 582
• Identity: 149/582 - (25%)
• Similarity: 203/582 - (34%)
• Gaps: 240/582 - (41%)

Human    11 LLGEQYYKDAMEQCHNYNARLCAERSVRL--PFLDSQTGVAQSNCYIWMEKR-------HRGPGL 66
            ::.|..|.|.|..|..:|:|...:|..||  |:.:.||..||      .|.|       |..|..
 Worm     1 MISENGYMDLMRNCIKWNSRQMEDRKKRLRFPYYEHQTATAQ------RESRFTTRNVDHMYPSN 59

Human    67 ASGQLYSYPARRWRKKRRAHPPEDP-RLSF-----PSIKPDTDQ--------TLKKEGLISQDGS 117
            ....:..:...|| ||.::.||.|. .:|.     |||:...|.        |.:.....|.|.:
 Worm    60 DPNTVVQFATERW-KKSKSQPPSDAVEMSMFLRENPSIQVAIDHLTPQVVGPTTESVSDSSNDST 123

Human   118 SLEALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRRGK 182
            ::....:|. :::....|..:||:                |.||:|..|.||
 Worm   124 TIRPSRQTQ-IKEEYRDDYVLDDE----------------LSPDEFGSDEDD------------- 158

Human   183 GKSKGKGVGSARKKLDASILEDRDKPYACDSECLTSGWVDLALDPAPALDMRGGRVVFLPRVLKQ 247
                                                                             
 Worm   159 ----------------------------------------------------------------- 158

Human   248 TWALVLPADCFRLRPLGGLGPCYMTGGTCMLWERFLPSSGVGLLVGATAGRVGLSTDGLQVSWPQ 312
             |:       .|.|..|.|||                      :..||:.|..:
 Worm   159 -WS-------SRKRRKGNLGP----------------------VQKATSSRKKV----------- 182

Human   313 LSQGPRGLTLSFSTSVLFFFLSALPHFCPSTLGAPSPLGFLSRLLCFPAAAAPVSSVSR--PSSH 375
                                        |:|.                      |||||  ||.
 Worm   183 ----------------------------PTTR----------------------SSVSRLTPSR- 196

Human   376 DFSFCLSDSFKQKHTSKAPQRVCGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEE 440
              |......:::......|...|..:||:..|||||.::.|       |::.|||...:...|.|
 Worm   197 --SIVKETKYEEPEEKTYPCDKCSAKYKSLAGLSYHQSYLH-------DQKSSQPLVKLLSPSIE 252

Human   441 QKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYR 505
            ..:.            ||||.|.:.:||.|..||:||||.|||||||||||.|...:...:|...
 Worm   253 ISTS------------CDFCSGTAFMNKNTKLPEDLVSCHDCGRSGHPSCLNFNQNVTKIIKRSG 305

Human   506 WQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKAS 567
            |||:|||.|.|||||||||:||||||||||||:|||||::.:.|:..:||.||.....:|||
 Worm   306 WQCLECKSCTICGTSENDDKLLFCDDCDRGYHLYCLTPALEKAPDDEYSCRLCQVEFGDKAS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DPF2	XP_024304405.1	Requiem_N	13..79	CDD:316564	19/74 (26%)
		SFP1	<397..417	CDD:227516	8/19 (42%)
		PHD1_DPF2_like	456..511	CDD:277161	30/54 (56%)
		PHD2_d4	513..558	CDD:277005	30/44 (68%)
dpff-1	NP_498281.2	Requiem_N	3..77	CDD:290758	23/80 (29%)
		SFP1	<19..236	CDD:227516	69/419 (16%)
		PHD1_MOZ_d4	257..311	CDD:277001	30/53 (57%)
		PHD2_d4	313..358	CDD:277005	30/44 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161464259
Domainoid	1	1.000	109	1.000	Domainoid score	I4390
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I2697
Isobase	1	0.950	-	0	Normalized mean entropy	S3744
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm16502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5121
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980