Protein Alignment UPF1 and NAM7

DIOPT Version :10

• Sequence 1: XP_016882594.1
• Gene: UPF1 / 5976
• HGNCID: 9962
• Length: 1137
• Species: Homo sapiens
• Sequence 2: NP_013797.1
• Gene: NAM7 / 855104
• SGDID: S000004685
• Length: 971
• Species: Saccharomyces cerevisiae
• Alignment Length: 880
• Identity: 476/880 - (54%)
• Similarity: 620/880 - (70%)
• Gaps: 41/880 - (4%)

Human    84 LQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI------------HACSYCGIHDPACVVY 136
            :.|...|.:|...:||.:.| .|:|:.|....::..:            ::|:||||....||:.
Yeast    12 ISNSPSDVNVQPATQLNSTL-VEDDDVDNQLFEEAQVTETGFRSPSASDNSCAYCGIDSAKCVIK 75

Human   137 CNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKA 201
            ||:.||||||.:..||.||||||||.:....|:||.|..||:|||||||||.:|||||||:.||:
Yeast    76 CNSCKKWFCNTKNGTSSSHIVNHLVLSHHNVVSLHPDSDLGDTVLECYNCGRKNVFLLGFVSAKS 140

Human   202 DSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLE 266
            ::|||||||.|||   ..|:.|||:.||||||:||..|||:.:.|:|:|:|:||.||..||:|||
Yeast   141 EAVVVLLCRIPCA---QTKNANWDTDQWQPLIEDRQLLSWVAEQPTEEEKLKARLITPSQISKLE 202

Human   267 ELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITV 331
            ..|:.|..||:.|::.|...|....:||||:|||:||..:|||:||||||||:|||||..::|:|
Yeast   203 AKWRSNKDATINDIDAPEEQEAIPPLLLRYQDAYEYQRSYGPLIKLEADYDKQLKESQALEHISV 267

Human   332 RWDLGLNKKRIAYFTLPKTDSGNEDLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPD 396
            .|.|.||.:.:|.|||...:|          .::::..|||:.|.|.|...|.|:|.|:::::|:
Yeast   268 SWSLALNNRHLASFTLSTFES----------NELKVAIGDEMILWYSGMQHPDWEGRGYIVRLPN 322

Human   397 NANLTQHTDYGDEIAIELR-SSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYI 460
            :        :.|...:||: |....|..:|..|..:|:||.||:||||.|||.||:|:.|:|||:
Yeast   323 S--------FQDTFTLELKPSKTPPPTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYL 379

Human   461 YHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIV 525
            |:|:|||:|.|:.....|||.|:......||.||..||..|||||||||||||||||||||||||
Yeast   380 YYKILGHQVVDISFDVPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIV 444

Human   526 YHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSM 590
            |||::.....:|||||||:|||.|..|:...|||||||.|||||.::|.||.|||||.: ...:.
Yeast   445 YHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSVSNLALHNLV-GRGAK 508

Human   591 PELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILID 655
            .||:.|.:||||.||||::|.||:..|.|..|.|:|..|||:|||||||||.|| ..:||::|||
Yeast   509 GELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRL-DTKFRTVLID 572

Human   656 ESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ 720
            |||||:||||::|:|.||||:||||||.|||||::.:|||.|||.|||||||:.||..||||:||
Yeast   573 ESTQASEPECLIPIVKGAKQVILVGDHQQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQ 637

Human   721 YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLN 785
            |||:|.||.||||:|||||||||||...|......|.||....||.|:...|:|||:::|||:||
Yeast   638 YRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSFLN 702

Human   786 RTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQG 850
            |.||.|.|:|.|||.:.|.||:|||:||||||||:|::||||.:|||...||.:||:||||||||
Yeast   703 RIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQG 767

Human   851 REKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQK 915
            ||||:||||||||||.|.||||.|||||||.||||:||::|:|||::|::..||||||.:::|:.
Yeast   768 REKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKG 832

Human   916 VLVEGPLNNLRESLMQF--SKPRKLVNTINPGARF 948
            .||||.|:||:...:|.  .:|||....:|  |:|
Yeast   833 CLVEGTLDNLQLCTVQLVRPQPRKTERPMN--AQF 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UPF1	XP_016882594.1	UPF1_Zn_bind	121..272	CDD:401391	88/150 (59%)
		TIGR00376	370..919	CDD:273041	324/549 (59%)
		DEXXQc_UPF1	489..722	CDD:350797	151/232 (65%)
NAM7	NP_013797.1	UPF1_Zn_bind	61..208	CDD:401391	88/149 (59%)
		UPF1_1B_dom	260..352	CDD:407973	30/109 (28%)
		TIGR00376	357..836	CDD:273041	302/480 (63%)
		DEXXQc_UPF1	408..639	CDD:350797	151/232 (65%)