Protein Alignment UPF1 and Setx

DIOPT Version :10

• Sequence 1: XP_016882594.1
• Gene: UPF1 / 5976
• HGNCID: 9962
• Length: 1137
• Species: Homo sapiens
• Sequence 2: NP_001137907.1
• Gene: Setx / 38904
• FlyBaseID: FBgn0035842
• Length: 1676
• Species: Drosophila melanogaster
• Alignment Length: 773
• Identity: 209/773 - (27%)
• Similarity: 328/773 - (42%)
• Gaps: 210/773 - (27%)

Human   290 QHVLL----RYEDAYQYQNIFGPLVKL------EADYDKKLKES--------QTQDNITVRWDLG 336
            |.||:    .::....|:.||.||:||      |.||....|.:        :||| :..|....
  Fly   993 QDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQD-MCYRLVTR 1056

Human   337 LNKKRIAYFTL--------PKTDSGNEDLVIIWLRDMRLMQGDEICLRY---KGDLAPLWKGIGH 390
            :|.|....|.|        .|....|       |.:::.:.|:...|.:   |.|::.      .
  Fly  1057 VNSKPFGKFVLYTLYCCGMLKETFAN-------LLELKFVSGNVFDLTFEILKQDISE------E 1108

Human   391 VIKVPDNANLTQHTDYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALK-TFAVDET 454
            .:|     |:.|.|  ...:...||..:|| :...|..:        |....:..|| |..|:|.
  Fly  1109 KLK-----NIKQLT--ARPVVDSLRVELGA-LSAVHQLR--------SSPLCRRILKPTQTVNEV 1157

Human   455 SVSGYIYHKLLGHEVEDVIIKCQLPKR-FTAQGLPDLNHSQVYAVKTVLQR-------PLSLIQG 511
            |                      |||: ||.:|...||..|...|....||       .|:||||
  Fly  1158 S----------------------LPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQG 1200

Human   512 PPGTGKT-----VTSATIVYHLARQGNGPVLVCAPSNIAVDQLT------------EKIH--QTG 557
            ||||||:     :...|:..:.|:..:..:|:||.||.|||.:.            ::.|  :.|
  Fly  1201 PPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFG 1265

Human   558 L-----------------------KVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQK---- 595
            :                       |:.|:..::.|.:...      ||.::  |.:.:|::
  Fly  1266 MHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQ------HNDLK--DEIQQLKEKTNL 1322

Human   596 -----LQQLKDETGELSSADEKRYRALKRTAEREL----LMNADVICCT---CVGAGDPRLAK-M 647
                 ||||:.:..:|.....:....|.:..|.|:    :..|::||.|   ||     :||. :
  Fly  1323 TSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV-----KLANYV 1382

Human   648 QFRSI-LIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLV--- 708
            .|..| ::||:||.|||..::|:..|...::||||..||..||:.|||...|||.|:|:|:.
  Fly  1383 DFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSL 1447

Human   709 -----------VLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPD 762
                       ::..:..:|..||||||.:..:|:..|||..|.|....|         ::..|.
  Fly  1448 QTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTA---------RFASPL 1503

Human   763 KPMFFYVTQGQEEIASSGT---SYLNRTEAANVEKITTKLLK-AGAKPDQIGIITPYEGQRSYLV 823
            .|  :.|...:....|:|.   |..|..||..|.|:.|::.| ..:|....|:|:||:.|...|.
  Fly  1504 IP--YCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALS 1566

Human   824 QYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYG 888
            |.:        ..:..:...:||::||.|||.||:|..|.   :|.|||.:.:||||||||.|..
  Fly  1567 QVI--------PSHMNITPQTVDSYQGLEKDVIIISNART---RGCGFLTNYQRLNVALTRPRRC 1620

Human   889 VIIVGNPKALSKQPLWNHLLNYYKEQKV---LVEGPLNNLRESLMQFSKPRKLVNTIN 943
            ::|.||.:.|....:|.:||:..:::||   |....:|:|..||::    :.:|||||
  Fly  1621 LVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDRDDVNDLDRSLIK----KMMVNTIN 1674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UPF1	XP_016882594.1	UPF1_Zn_bind	121..272	CDD:401391
		TIGR00376	370..919	CDD:273041	175/641 (27%)
		DEXXQc_UPF1	489..722	CDD:350797	82/313 (26%)
Setx	NP_001137907.1	FHA	12..94	CDD:438714
		AAA_11	1175..1428	CDD:404072	69/265 (26%)
		DNA2	<1299..1646	CDD:440729	115/381 (30%)