Protein Alignment UPF1 and Mov10

DIOPT Version :10

• Sequence 1: XP_016882594.1
• Gene: UPF1 / 5976
• HGNCID: 9962
• Length: 1137
• Species: Homo sapiens
• Sequence 2: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Alignment Length: 833
• Identity: 201/833 - (24%)
• Similarity: 313/833 - (37%)
• Gaps: 239/833 - (28%)

Human   251 QLRARQITAQQINKL--EELWKENPSATLEDLEKPGVDEE-------------PQHVLLR----- 295
            ||....:..|:::||  :..:|..| ...||...|.:|:.             |:.::|.
  Fly    64 QLIQSDVPVQRVSKLTYKITFKSTP-VNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPHP 127

Human   296 YEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII 360
            :||.....    |:::..|..||     .:...:.||:    ::|..|..      ||.....||
  Fly   128 HEDLEPGD----PMLRHVASVDK-----VSSTTVHVRF----SRKHKAVL------SGQRFYAII 173

Human   361 ---------WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNANLTQHTDYGDEIAIELRS 416
                     ..|.:.|:|...:..||.... |.|              |||..|
  Fly   174 RSRRLTIRYMYRALNLLQESPLVRRYLFPF-PSW--------------LTQLVD----------- 212

Human   417 SVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKR 481
                      |.|:                      :....|::.:.:.|...|        |..
  Fly   213 ----------NSQI----------------------KVCCDGHLPNWMQGRPQE--------PAT 237

Human   482 FTAQGLPD----LNHSQVYAVKTVLQRPLS----LIQGPPGTGKTVTSATIVYHL-ARQGNGPVL 537
            .|:..|.:    .|..|:.||:.::..|.:    ::.||||||||.|....:..| .:|....:|
  Fly   238 PTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSRIL 302

Human   538 VCAPSNIAVDQLTEKIHQTGLKVVRLCAK-SREAIDSPVSFLALHNQIR---------NMDSMPE 592
            |.|.||.|.|.:..|:.:.....:||... :::.:..|.     |..||         ...|:|.
  Fly   303 VTAGSNSACDTIALKLCEYIESNIRLQEHFAQQKLPEPD-----HQLIRVYSRSIYEKGFASVPS 362

Human   593 LQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVI---CCTCVGAGDPRLAKMQ-FRSIL 653
            |    .||:     |:..:..|..:|  |.|  ::...:|   .||........|.:.. |..|.
  Fly   363 L----LLKN-----SNCSKSIYDHIK--ASR--IVKYGIIVATLCTVARLVTDTLGRYNFFTHIF 414

Human   654 IDESTQATEPECMVPVVLGAKQ-----LILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGI- 712
            |||:..:||||.::. ::|.||     :||.|||.|||.|:...:||..|||:||.|||:....
  Fly   415 IDEAGASTEPEALIG-IMGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCY 478

Human   713 -----------RPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQW---PQPDK 763
                       |.:||...||.||.:....:.::|.|.|:....|.|   ......|   ..|..
  Fly   479 KSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMD---VNLAANWSVLTNPQF 540

Human   764 PMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLK---AGAKPDQIGIITPYEGQRSYLVQY 825
            |:.|..|.|......:.||..|..||..:.....:|:.   .|  .:.:||:.||..|...:.:.
  Fly   541 PIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVG--QEDVGIVAPYTAQGKLVTKL 603

Human   826 MQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVI 890
            :|..|      |..||:.||:.:|||||..||.|.|::  ...:||:.:|||:||.|:||:..:|
  Fly   604 LQSKG------YPNVEVGSVETYQGREKTIIIASLVKS--FTNMGFMCNPRRVNVLLSRAKALLI 660

Human   891 IVGNPKALSKQPLWNHLLNYYKEQ--------------KVLVEGPLNNLRESLMQFSKPRKLVNT 941
            :||||..|.....:..::|..|:.              .:|::...:|...|    |:|.
  Fly   661 LVGNPVTLRHHSDFKFVINECKKHGTYLLKKRDSGQRPHILIKADESNEESS----SEPE----- 716

Human   942 INPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSH 994
                         |..:.:||.  |.|..|        .|...|..|.|.|::
  Fly   717 -------------DEDDKLIPS--YARMQQ--------HTDAAIHKIKAHPTN 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UPF1	XP_016882594.1	UPF1_Zn_bind	121..272	CDD:401391	6/22 (27%)
		TIGR00376	370..919	CDD:273041	156/608 (26%)
		DEXXQc_UPF1	489..722	CDD:350797	78/272 (29%)
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	78/266 (29%)
		DNA2	<388..684	CDD:440729	99/309 (32%)