Protein Alignment UPF1 and CG6701

DIOPT Version :10

• Sequence 1: XP_016882594.1
• Gene: UPF1 / 5976
• HGNCID: 9962
• Length: 1137
• Species: Homo sapiens
• Sequence 2: NP_610920.3
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Alignment Length: 1282
• Identity: 275/1282 - (21%)
• Similarity: 466/1282 - (36%)
• Gaps: 394/1282 - (30%)

Human    25 GADTQGSEFEFTDFTLPSQTQTPPGGPG---------------------------------GPGG 56
            ||...||....|:|.:    .||.|.|.                                 .|||
  Fly   108 GATNIGSLLHRTNFLI----NTPRGNPNYRIKNFSLMDFRKEKFNLLDEQHRLRGIASTTDVPGG 168

Human    57 GGAGGPGGAGAGAAAGQLDAQVGP------EGILQNGAVDDSVAKTSQLLAELNFEE-------- 107
            ..|.|....   ....:||..|.|      :.:|.....|..:......:.:.|||:
  Fly   169 APAEGNKPI---IEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHV 230

Human   108 ----DEEDTYYTKDL-----PIHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRA 163
                ||.|....|.:     ||.:.||     ..||                  .||.....::.
  Fly   231 EYHGDESDFQSLKKMKKYPTPIVSLSY-----QTCV------------------DSHYFGFTLKT 272

Human   164 KCKEVTLHK---------------DGPL-----GETVLECYNCGCRNVFLLGFIPAKADSVVVLL 208
            ..|::.:.|               ..||     ||.|.              |:    ||.|.::
  Fly   273 FRKDLVVDKFIIVQLRQFYYVYGAQMPLPVNGSGELVF--------------FV----DSHVFMI 319

Human   209 CR-QPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKEN 272
            .| ||.....::        |.:..::...|:. ...:|.....:...::::::..|.:.|...|
  Fly   320 LREQPIVIGFTI--------QGEKYVEQHHFMR-TEALPKASFNINPYRLSSKETFKSKGLPPAN 375

Human   273 PSATLEDLEKPGVDEEPQHVLLRYEDAYQ----------YQNIFG---PLVKLEADYDK-----K 319
            |...:....|   .|:.|..|..:::.||          .:|:.|   .|:::| |.::     .
  Fly   376 PPIQVLSALK---HEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVE-DIERLQHYLS 436

Human   320 LKESQTQ-----DNITVRWDLG------------------LNKKRIAYFTLPKTDSGNEDLVIIW 361
            ||:|:.:     ..::|:..:|                  :|:|......:.|....|.:::.:.
  Fly   437 LKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELA 501

Human   362 LRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVP------------DNANLTQHTDYGDEIAIEL 414
            |:|.     |.| ||:..::..:   :|.:.|.|            ...|:|......|.....|
  Fly   502 LKDF-----DSI-LRWARNVDGM---VGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTL 557

Human   415 RSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLP 479
               :..|:.....:|...: :..||.|                    |.    :|:.::...::|
  Fly   558 ---IFRPLRAVMRYQYRAL-QQLSFTR--------------------HS----DVQRILFPGEIP 594

Human   480 KRFTAQGLPDLNH-------SQVYAVKTV-----LQRPLSLIQGPPGTGKTVTSATIVYHLARQG 532
            ....|.|:..||:       .|:.||:.:     |:.|. ::.||||||||.|....:|.|  ..
  Fly   595 NTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPY-IVFGPPGTGKTSTIVEAIYQL--YI 656

Human   533 NGP---VLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHN---QIRNMDSM- 590
            |.|   :||.|.||.|.|::       .|:::|..||:.::...|::.:...|   :|.|:|.:
  Fly   657 NRPETHILVLAGSNTACDEV-------ALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLL 714

Human   591 ------------PELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPR 643
                        |.:|.:.|               ||               ::.||...||  :
  Fly   715 LEYSNMYTVHFYPAVQAVHQ---------------YR---------------IVICTLSLAG--K 747

Human   644 L------AKMQFRSILIDESTQATEPECMVPVVLGAK---QLILVGDHCQLGPVVMCKKAAKAGL 699
            |      |...:..:.:||:..:||.|.::.:.....   .|||.|||.|||||:..::|.:.||
  Fly   748 LSTGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGL 812

Human   700 SQSLFERLVVLGIRPI------------RLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKK 752
            ..:|||||:......:            ||...:|.||.:.:..:|::|||.|:  ..|...:..
  Fly   813 GLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLR--TEAPMEIVC 875

Human   753 GFD--FQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQ-----IG 810
            .|.  |..|....|:.|:...|......|..|..|..|...|......|:..|...::     ||
  Fly   876 RFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIG 940

Human   811 IITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDP 875
            ||:||:.      ||.:....|:.:.:.:::..||:.|||:||..||:|.||:...: :||||:.
  Fly   941 IISPYKN------QYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTPK-LGFLNNE 998

Human   876 RRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLV---------------------- 918
            |||||.|:|....:|::|||:.||:...:.|::...:.:|.||
  Fly   999 RRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQYLNEDFITNKKTGANNVNK 1063

Human   919 -----EGPLNNLRESLMQ-------------FSKPRKLVNTINPGARFMT--TAMYDAREAIIPG 963
                 :.|.:.||:.|.:             |....:|:|..|...|..:  ..::|.... :|.
  Fly  1064 GGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPK-VPR 1127

Human   964 SV-YD----RSSQGRPSSMYFQT-HDQIG---MISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQ 1019
            || :|    ||.:.:......:| .|..|   :::..|...||....||...:|....|..:...
  Fly  1128 SVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHSSS 1192

Human  1020 ANGPAAGRGTPKGKTGRGGRQKNRFGLPG-PSQTNLPNSQASQDVAS 1065
            .:.||..:.|....|...   |:|..:|. ||.:..|.|.:|..:::
  Fly  1193 VSRPAIRKPTVSAATPVA---KSRSPMPEIPSSSKHPISMSSNPLST 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UPF1	XP_016882594.1	UPF1_Zn_bind	121..272	CDD:401391	25/171 (15%)
		TIGR00376	370..919	CDD:273041	158/646 (24%)
		DEXXQc_UPF1	489..722	CDD:350797	73/284 (26%)
CG6701	NP_610920.3	DEXXQc_Helz-like	611..847	CDD:350796	71/277 (26%)
		SF1_C_Upf1	848..1035	CDD:350195	60/195 (31%)