DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment REN and CG6508

DIOPT Version :9

Sequence 1:	NP_000528.1	Gene:	REN / 5972	HGNCID:	9958	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	127/345 - (36%)
Similarity:	191/345 - (55%)	Gaps:	30/345 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    71 NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDS 135
            ::.::.:|.|..:.:|...:.||||||.|.:.||||||::||||.|||....||..|..:::|.|
  Fly    59 SSQTTQVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNSSAS 123

Human   136 SSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFI 199
            ||:..:|...:::|.:|::|||||.|.:.:.|:.: .|.|.|..:.|...|:...|||::||.|.
  Fly   124 SSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGMAFA 188

Human   200 EQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKT 264
            ..:.|..|| |||||.||::|..|||.|..||. .||| ||:::.||.|...|.|..:|:.:...
  Fly   189 SISGGVTTP-FDNIIRQGLVKHPVFSVYLRRDG-TSQS-GGEVIWGGIDRSIYRGCINYVPVSMP 250

Human   265 GVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYIS---GSTSSIEKLMEALGAKKRLFDYVVKCN 326
            ..||.....|.: ...||| :||.|:.|||.|.|:   .:..:|.|::.|..|...  :..|.|:
  Fly   251 AYWQFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDG--EAFVDCS 311

Human   327 EGPTLPDISFHLGGKEYTLTSADYVFQ-ESYSSKKLCTLAIHAMDIPPPTGPT-------WALGA 383
            ....||:::.::||..||||..||::: ::.:::.||.           :|.|       |.||.
  Fly   312 SLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCL-----------SGFTYLQGNLLWILGD 365

Human   384 TFIRKFYTEFDRRNNRIGFA 403
            .|:.|.||.||....|||||
  Fly   366 IFLGKVYTVFDVGKERIGFA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REN	NP_000528.1	A1_Propeptide	33..>51	CDD:311771
REN	NP_000528.1	renin_like	78..405	CDD:133154	127/338 (38%)
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	126/336 (38%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	125/331 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.820