Protein Alignment RELA and dl

DIOPT Version :10

• Sequence 1: NP_001391586.1
• Gene: RELA / 5970
• HGNCID: 9955
• Length: 562
• Species: Homo sapiens
• Sequence 2: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 153/372 - (41%)
• Similarity: 201/372 - (54%)
• Gaps: 42/372 - (11%)

Human    19 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKVWMSGPLYFGQINGYTGPGTV 83
            |||:|.|||..:.:||||:|||||||||||..||...||:|||           :|.||.|...|
  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTI-----------EIVGYKGRAVV 100

Human    84 RISLVTKDPPHRPHPHELVGKD-CRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQT 147
            .:|.||||.|:|||||.||||: |:.|....|:..:.....|.|||||||||:|:|.|:..|.:.
  Fly   101 VVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEI 165

Human   148 NNNPFQVPIEE--QRGDYDLNAVRLCFQVTVR-DPSGR---PLRLPPVLSHPIFDNRAPNTAELK 206
            ..:||:.....  |....|||:|||||||.:. :..||   |  ||||:|.||||.:|  .::|.
  Fly   166 RVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSP--LPPVVSEPIFDKKA--MSDLV 226

Human   207 ICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYF----TGPG-WEARGSFSQADVHRQVAIVFRTP 266
            |||:...|.:..|..:|.|||:||.||||.|.|    .|.. |||.|.|...|||:|.||.|:||
  Fly   227 ICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTP 291

Human   267 PYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRI-----EEKRKRTYETFKSIMKK 326
            .|....:..|.:|.:|||||||...||.:.|:|:|....:|..     ..|||...:.|:.|::
  Fly   292 RYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILR- 355

Human   327 SPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDE 373
              .....:.:||...:.........|.:..|....|       |::|
  Fly   356 --LDAKREVQPPTIEVIDLDTPKIDVQREIPSEMEF-------NHEE 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RELA	NP_001391586.1	RHD-n_RelA	19..198	CDD:143645	91/185 (49%)
		IPT_NFkappaB	205..301	CDD:238582	47/100 (47%)
		Nuclear localization signal. /evidence=ECO:0000255	312..315		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..359		6/38 (16%)
		Transcriptional activation domain 3. /evidence=ECO:0000250|UniProtKB:Q04207	353..400		4/21 (19%)
		Transcriptional activation domain 1. /evidence=ECO:0000269|PubMed:1732726	426..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..541
		Transcriptional activation domain 2. /evidence=ECO:0000250|UniProtKB:Q04207	531..562
		9aaTAD. /evidence=ECO:0000255	547..555
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	91/185 (49%)
		IPT_NFkappaB	225..326	CDD:238582	47/100 (47%)