DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRPH2 and Tsp86D

DIOPT Version :9

Sequence 1:	NP_000313.2	Gene:	PRPH2 / 5961	HGNCID:	9942	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_001262468.1	Gene:	Tsp86D / 41310	FlyBaseID:	FBgn0037848	Length:	316	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	75/306 - (24%)
Similarity:	129/306 - (42%)	Gaps:	78/306 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    20 LWLMNWFSVLAGIIIFSLGLFLKIE--------LRKRS--DVMNNSESHFVPNSLIGMGVLSCVF 74
            ::|:|:...|.|.::.::|::..::        ||..:  ||:.|     :...:|..||:  ||
  Fly    35 IFLLNFLFWLFGGLLLAIGVYAFMDKLMDGNGWLRLDTIYDVIFN-----ISLVMIIAGVI--VF 92

Human    75 N-SLAGKICYDALDPAKYARWKPWLKPYLAIC-VLFNIILFLVALCCFLLRGSLENTLGQGLKNG 137
            . |.||  |..||      |...||....::| :||.|:...:|:.||:        ..|.:.:.
  Fly    93 TVSFAG--CLGAL------RENTWLLKLYSMCLLLFFILEMSLAIICFV--------FPQYMNSF 141

Human   138 MKY---------YRDTDTPGRCFMKKTIDMLQIEFKCCG--NNGFRDWFEIQWISNRYLDFSSKE 191
            ::|         |||...     ::..||..|.||.|||  |.|::||.:     |.|.:.||..
  Fly   142 LEYQFTDKIIHSYRDDSD-----LQNFIDFAQQEFNCCGLSNAGYQDWSK-----NEYFNCSSPS 196

Human   192 VKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQT---EELNLWVRGCRAA 253
            | :|.           |||:|||..::.   |...:.|....|....::   ....:|..||...
  Fly   197 V-ERC-----------GVPYSCCINATD---ISSGLVNIMCGYGVQVRSVAAASKRIWTSGCIEI 246

Human   254 LLSYYSSLMNSMGVVTLLIWLFEVTITIGLRYLQTSLDGVSNPEES 299
            :..:....:..:..|.|.|.|.::.:.    ||..:|:|..:.::|
  Fly   247 VRVWVERNLYVIAGVALGIALLQLFVI----YLAKTLEGQIDLQKS 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRPH2	NP_000313.2	Tetraspannin	20..277	CDD:278750	70/282 (25%)
		peripherin_like_LEL	120..262	CDD:239415	36/155 (23%)
		Interaction with MREG. /evidence=ECO:0000250	341..346
Tsp86D	NP_001262468.1	Tetraspannin	51..283	CDD:278750	70/283 (25%)
Tsp86D	NP_001262468.1	penumbra_like_LEL	132..255	CDD:239411	36/155 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810