DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BCL2 and Buffy

DIOPT Version :9

Sequence 1:	NP_000624.2	Gene:	BCL2 / 596	HGNCID:	990	Length:	239	Species:	Homo sapiens
Sequence 2:	NP_523702.1	Gene:	Buffy / 36251	FlyBaseID:	FBgn0040491	Length:	299	Species:	Drosophila melanogaster

Alignment Length:	153	Identity:	39/153 - (25%)
Similarity:	64/153 - (41%)	Gaps:	25/153 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    79 GAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFAT----------V 133
            |:.:...:..|.|.|.:    .||:..|.:.|.:..::.|:...|   .|.|.|          |
  Fly   125 GSTSMGIVRDVFPAVQV----LGDELERMHPRIYNGVARQICRNP---GGEFHTPDAVSLLLGAV 182

Human   134 VEELFRDGVNWGRIVAFFEFGG---VMCVESVNREMSP-LVDNIALWMTEYLNRHLHTWIQDNGG 194
            ..||||..:.|.::::.|...|   |.||...:.|..| |::::    :|.:...|..||.:|||
  Fly   183 GRELFRVEITWSKVISLFAIAGGLSVDCVRQGHPEYLPKLMESV----SEVIEDELVPWINENGG 243

Human   195 WDAFVELYGPSMRPLFDFSWLSL 217
            |........|:...|....|.:|
  Fly   244 WSGINTHVLPTTNSLNPLEWTTL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCL2	NP_000624.2	bcl-2	1..239	CDD:273308	39/153 (25%)
		BH4	10..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..85		1/5 (20%)
		BH3	93..107		3/13 (23%)
		BH1	136..155		6/18 (33%)
		BH2	187..202		6/14 (43%)
Buffy	NP_523702.1	Bcl-2_like	99..250	CDD:132900	35/135 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910