DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RCN2 and CG31650

DIOPT Version :9

Sequence 1:	NP_001258766.1	Gene:	RCN2 / 5955	HGNCID:	9935	Length:	335	Species:	Homo sapiens
Sequence 2:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	117/363 - (32%)
Similarity:	185/363 - (50%)	Gaps:	54/363 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     5 PRTAALGLLLLCA--------------AAAGAGKAEE----------LHYPL--------GERRS 37
            ||...|..|.|||              |.|.:.|.|:          ::.|.        ||...
  Fly     2 PRNLPLLPLTLCAVALLAAVGPMPAHGAVANSHKHEKHLSKERVKDGIYAPRDAHHHGEDGEHNV 66

Human    38 DYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEA 102
            ::|.||::|..::..|:..|..:|.::||..:||.:||:.|.|:...||.:||..|||..:.:||
  Fly    67 EFDHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDLNKDEFIDRHELKAWILRSFKKLSEEEA 131

Human   103 KQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKEFAICKKQSFCFWLLRFN 167
            ..:|.|.|:::|:.:||.||   :.|.....||:...:..:.:|:..|..:.|
  Fly   132 ADRFEEIDQDADERITWKEY---LQDTYAMEDEDFKKETIDYDSYEDEQKMIK------------ 181

Human   168 LHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGD 232
               :||:.|..|:.:....|:||||:.|::|||...|...:::..:::.|.:.||.::.:||:|
  Fly   182 ---QDKEMFNAADTNKDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKINFQEFVG- 242

Human   233 YRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNG 297
               |..::.|.||::.||:||..|:|.:.||.|...|:|.|:||:|..||.:|..||....|.:.
  Fly   243 ---DAASHHDKEWLITEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVSTDEDH 304

Human   298 DKKLSEEEILENPDLFLTSEATDYGRQLHDDYFYHDEL 335
            |.:||..|||.|.|.|:.|||||||..|.:.....|||
  Fly   305 DDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDEL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RCN2	NP_001258766.1	EFh_CREC_RCN2	29..314	CDD:320022	94/292 (32%)
		EF-hand motif	29..59	CDD:320022	9/37 (24%)
		EF-hand motif	65..94	CDD:320022	12/28 (43%)
		EF-hand motif	101..130	CDD:320022	11/28 (39%)
		EF-hand motif	171..200	CDD:320022	11/28 (39%)
		EF-hand motif	208..237	CDD:320022	6/28 (21%)
		EF-hand motif	249..278	CDD:320022	14/28 (50%)
		EF-hand motif	285..314	CDD:320022	12/28 (43%)
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	22/55 (40%)
		EFh	100..153	CDD:298682	22/55 (40%)
		EF-hand_7	184..241	CDD:290234	17/56 (30%)
		EFh	184..241	CDD:298682	17/56 (30%)
		EFh	228..281	CDD:298682	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147156
Domainoid	1	1.000	58	1.000	Domainoid score	I10839
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2176
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3792
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46113
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		oto88494
orthoMCL	1	0.900	-	-		OOG6_108120
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8362
SonicParanoid	1	1.000	-	-		X5175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700