DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atp8b1 and atp8b1

DIOPT Version :9

Sequence 1:	NP_001025562.1	Gene:	atp8b1 / 594952	XenbaseID:	XB-GENE-490143	Length:	1250	Species:	Xenopus tropicalis
Sequence 2:	XP_001920510.4	Gene:	atp8b1 / 100148342	ZFINID:	ZDB-GENE-091116-14	Length:	1249	Species:	Danio rerio

Alignment Length:	1232	Identity:	856/1232 - (69%)
Similarity:	1014/1232 - (82%)	Gaps:	25/1232 - (2%)

- Green bases have known domain annotations that are detailed below.

Frog    12 DSQ----VPNDDVVPYSDDETDDELDSPQTDEPEQNRRNVQAEQSREPVIKECTWQVKANDRNFY 72
            |||    .|:|:|:||||||||.||:    ||.:|:...:...::|.....|..|.|:||||.:.
Zfish     8 DSQGSLDEPDDEVMPYSDDETDAELE----DELDQSVDQLPEPETRPAPAVEAGWSVRANDREYC 68

Frog    73 DQPEFKKKVFLCLKKSKYAGNAIKTYKYNPITFLPVNLYEQFKRAANAYFLVLLILQTIPQISTV 137
            .:|||:||||||:|||:|:||||||||||.:||||:|||||||||||.|||.||:||.||||||:
Zfish    69 KRPEFQKKVFLCIKKSRYSGNAIKTYKYNVLTFLPLNLYEQFKRAANLYFLCLLVLQIIPQISTL 133

Frog   138 TWSTTLIPLLLVLGITAIKDLVDDIARHKMDNEINNRPSEVITDGRFKKTKWKHIHVGDIIRINK 202
            .|.|||:||:||||||||||||||:|||:||.|||||..:|:.:|||.:|:|.::.|||::|::|
Zfish   134 PWYTTLVPLVLVLGITAIKDLVDDLARHRMDKEINNRKCDVLLNGRFVETRWMNLQVGDVVRLHK 198

Frog   203 NEFVPADVLLLSSSDPNSLCYVETAELDGETNLKFKMSLEITDKLLQKEEQLAGFDGLVECEEPN 267
            |:|:|||::|||:|:||||||||||||||||||||||.|::||:.||:|:||:.|:.||.|||||
Zfish   199 NDFIPADIMLLSTSNPNSLCYVETAELDGETNLKFKMGLKVTDERLQEEQQLSQFNALVMCEEPN 263

Frog   268 NRLDKFVGTLFWRGNSFGLDADKILLRGCTVRNTEYCHGLVLFAGADTKIMRNSGKTRLKRTKID 332
            |||||||||:.|...|:.||.|.:|||||.||||:.|||||:|||.|||||||.||||.|||:||
Zfish   264 NRLDKFVGTMIWESQSYALDLDNMLLRGCKVRNTDICHGLVIFAGNDTKIMRNGGKTRFKRTRID 328

Frog   333 YLMNYMVYTIFVLLILAAAGLAIGQTFWEAKLGAANVSWYLYDGNNYSPSYRGFLAFWGYIIVLN 397
            .|||||||||||||:|..||||||.|:|...:|:.  :|||.||.:|:.||||||:||||||:||
Zfish   329 KLMNYMVYTIFVLLVLLCAGLAIGHTYWYESIGSK--AWYLIDGLDYTSSYRGFLSFWGYIIILN 391

Frog   398 TMVPISLYVSVEVIRLGQSYFINWDLQMYFSPKDTPAKARTTTLNEQLGQIQYIFSDKTGTLTQN 462
            |||||||||||||||||||.|||||||||::.||||||:||||||||||||:|||||||||||||
Zfish   392 TMVPISLYVSVEVIRLGQSKFINWDLQMYYADKDTPAKSRTTTLNEQLGQIEYIFSDKTGTLTQN 456

Frog   463 IMTFKKCTINGTTYGDDD--DELKSGQTKQVDFSWNPLADPSFTFHDNYLIEQIRAGKDKDVYEF 525
            ||.||||||:|.|||:..  |.:...:.|.||||||..||..|.|.|::||..||:.||..|.||
Zfish   457 IMAFKKCTISGRTYGEPTTADGVSLDRGKPVDFSWNKYADRKFQFEDHFLISCIRSKKDPQVLEF 521

Frog   526 FKLLALCHTVMAEKTDGELIYQAASPDEGALVTAARNFGFVFLSRTQSTITISELGQEKTYEVLA 590
            ||||:||||||.|:.:|||:|||||||||||||||||||||||||||.||||.|:.:.:||.:||
Zfish   522 FKLLSLCHTVMVEEKEGELVYQAASPDEGALVTAARNFGFVFLSRTQDTITIQEMDKPQTYTMLA 586

Frog   591 ILDFNSDRKRMSIIVRQPDGRIRLYCKGADTVIYERLHPDNPIKDQTQKALDIFANASLRTLCLC 655
            :|||||||||||||::.|||||||||||||||||:||.|.:..|:.||:|||||||.:|||||||
Zfish   587 LLDFNSDRKRMSIILKFPDGRIRLYCKGADTVIYQRLSPQSKNKENTQEALDIFANETLRTLCLC 651

Frog   656 YKDINKGDFENWSKKYKQASVATSNRDEALDRVYEAIETDLKLLGATAIEDKLQDDVSGTIFNLA 720
            ||||::.:|:.||:|::.|:|:..:|:..||.|||.||.||.|:|||||||||||.|..||..||
Zfish   652 YKDISQEEFDRWSRKHQTAAVSMVDRERELDEVYEEIEKDLLLIGATAIEDKLQDGVPETIAKLA 716

Frog   721 RADIKIWVLTGDKKETAENIGYSCKLLDDDTEILYGEDINVHLQTRMENQRNQMSGNQGAQSNQS 785
            :|||||||||||||||||||||||:||.||.:|.||||:||.|:.|...:|   :..|.....|.
Zfish   717 KADIKIWVLTGDKKETAENIGYSCQLLTDDMKIHYGEDVNVQLRNRQTQRR---TDPQSRNKKQK 778

Frog   786 GAFLPTDKKHALIITGSWLNEILLEKKKRKKKRLKLKFPRTKEEKEQQLHEKLKAYAL------K 844
            .:|.....|:||||||.||||||.|||| |::||:||..|.::..:|.........:.      |
Zfish   779 ESFFNEPGKNALIITGGWLNEILYEKKK-KRRRLRLKKLRLRQNNQQSSSSTAPDSSQPVDDWEK 842

Frog   845 EQRQRSFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAVTLAIGDGANDVNMIKTAHIGVGIS 909
            |:||..|||:||||||||||||||||||.||.|||:|||||||:||||||||||||||.||||||
Zfish   843 EKRQEDFVDMACECSAVICCRVTPKQKANVVSLVKKYKKAVTLSIGDGANDVNMIKTADIGVGIS 907

Frog   910 GQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFSFTLVHFWYSFFNGFSA 974
            |||||||||||||:||||.:||||||||||||||||||||||||||||:|||||||:||||||||
Zfish   908 GQEGMQAVMSSDYAFAQFCFLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWFSFFNGFSA 972

Frog   975 QTVYEDWFITLYNVLYSSLPVLLVGLLDQDVSDKLSLAFPRLYVPGQKDLLFNYKKFFLSLFHGI 1039
            ||.|||||||||||.||||||||||||||||:|||||.||:||:|||:..||||:.||:||||||
Zfish   973 QTAYEDWFITLYNVCYSSLPVLLVGLLDQDVNDKLSLRFPKLYLPGQQGALFNYRNFFISLFHGI 1037

Frog  1040 VTSLIIFFIPYGAFLLTMGQDGEAPSDYQSFAVTTATALVITVNFQIGLDTSYWTFVNAFSIFGS 1104
            .|||:||||||||||.|||||||||||||||||..|::|:||||.||.|:||||||||.|::.||
Zfish  1038 FTSLMIFFIPYGAFLQTMGQDGEAPSDYQSFAVVAASSLIITVNLQISLNTSYWTFVNFFAVLGS 1102

Frog  1105 IAIYFGIMFDLHSAGIHVLFPSMFIFTGAAPNALRQPYLWLTIILTVAFCLLPIVALRFLAKTIW 1169
            ||:|||||||:|||||||:||:.|.|||||.||||||||||||||||..||||::.::||.:||:
Zfish  1103 IALYFGIMFDIHSAGIHVIFPNTFTFTGAASNALRQPYLWLTIILTVGVCLLPVICIQFLYQTIY 1167

Frog  1170 PSESDKIQKKGKKFKAEVE--QRAKPKP-FARGVSTRRSAYAFSHQRGYADLISSGRSIRKK 1228
            ||..||:|:..||::.|.|  :|.|.|| |.||..:|||||||||.|||||||:||||||::
Zfish  1168 PSVGDKVQRNRKKYELEDEEDERKKRKPTFQRGGRSRRSAYAFSHSRGYADLIASGRSIRQR 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atp8b1	NP_001025562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		19/43 (44%)
atp8b1	NP_001025562.1	P-type_ATPase_APLT_Dnf-like	92..1049	CDD:319770	686/964 (71%)
atp8b1	XP_001920510.4	PhoLip_ATPase_N	60..137	CDD:292826	57/76 (75%)
		ATPase-Plipid	86..1176	CDD:273734	784/1097 (71%)
		E1-E2_ATPase	142..>228	CDD:278548	58/85 (68%)
		Cation_ATPase	527..624	CDD:289987	77/96 (80%)
		HAD_like	<872..915	CDD:304363	38/42 (90%)
		PhoLip_ATPase_C	915..1169	CDD:292829	204/253 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I3777
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21151
Inparanoid	1	1.050	1723	1.000	Inparanoid score	I658
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		oto84285
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7967
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110