DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mark2 and par-1

DIOPT Version :9

Sequence 1:	XP_012808991.1	Gene:	mark2 / 594939	XenbaseID:	XB-GENE-876451	Length:	792	Species:	Xenopus tropicalis
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	435/831 - (52%)
Similarity:	535/831 - (64%)	Gaps:	124/831 - (14%)

- Green bases have known domain annotations that are detailed below.

Frog     6 AAKHRDH--PDSCTNPLL---------AHEPALGHADQKTSSSGSSKPNM-LRCRTSIATTADEQ 58
            |..|..|  |.|...|.:         ||..|:   .|:|||:..| ||| :|....:...|.|:
  Fly   188 AINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAI---KQRTSSAKGS-PNMQMRSSAPMRWRATEE 248

Frog    59 PHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 123
             |||.|:|:||||||||||||||:|:.||||||:|||||||||..|||||||||||||:|:||||
  Fly   249 -HIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312

Frog   124 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLK 188
            ||||:||||||||||:||||||||||||||.||||||||||.|||||||||||||||.|:|||||
  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377

Frog   189 AENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 253
            ||||||||::||||||||||||||.|:||||||||||||||||||||||||||||||||||||||
  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442

Frog   254 LVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVG 318
            ||||||||||..|:|||||||||||||||||||||||||:|||:||||||.:||.||.|:|||:|
  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507

Frog   319 HEEDELKPYVEPIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGYKSSETDND- 382
            .||||||||:||..|..||||.|.::.|||.|.||..||...:|::|.|||||||.||::.::|
  Fly   508 FEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDG 572

Frog   383 -----NLTLKPRPPPD----VTNSIAPSPAHK-VQRSVSANPKQ--RRLSDQAGP---------- 425
                 :|:|:.....|    ..::...||.|: |.||:||:..:  ||.|...||
  Fly   573 SRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAA 637

Frog   426 -----AIPNSNSYSKKTQSNNAENRRS--EDDKESGRKSSSTVRVPPSPLSGLDRKKTTPTPSTN 483
                 |:..||:|:   .:.:|.:|.|  .:.|......|:|::...:.|:..:::   |..:|.
  Fly   638 TGAVGAVNPSNNYN---AAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQR---PASATQ 696

Frog   484 SVLSTGTNRSRNSPMLDRASLVPGSVQNGKDSFSTPG--SRASTASAPATSARIRQHQKSMSTSV 546
            .:|:| .:.:.|||...|.:.........:....|.|  .|.||.....||:       :..|:|
  Fly   697 KMLTT-ADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSS-------TEKTNV 753

Frog   547 HPSKPAPSLDGNCEVQRPSTAPQRVPVASPSAHNISSAATERTNFPRGVSSRSTFHAGQVRQARD 611
            .|::              :....|:.:|        ||.....:|||.|.||||||:||.| ||:
  Fly   754 IPAE--------------TNLFDRLRMA--------SAVKSSRHFPRNVPSRSTFHSGQTR-ARN 795

Frog   612 QQNLGFGSVSPASPSGNSQGRRGATGSIFSKFTSKFVRRNLSFRFPRRNPNEPEGKDRVESTRPH 676
            ...|.:...|.||...:..||.    |.|||.:|:|                        |.||
  Fly   796 NTALEYSGTSGASGDSSHPGRM----SFFSKLSSRF------------------------SKRP- 831

Frog   677 LTVLDKEKDKEDHRDSKPRSLRFTWSMKTTSSMEPNEMMSEIRKVLDANNCQHESQEKYMLLCVH 741
             |:.|:.        :|||.|||||||||||.:.|:::|.:||:|||.|||.:|.:|:::|.|||
  Fly   832 -TIADEA--------AKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVH 887

Frog   742 GTPGHDNYVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 792
            |.|..|:.||||:|||||||||||||||||||||||.||||||:||.:|||
  Fly   888 GDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	220/251 (88%)
		UBA_MARK2	333..374	CDD:270589	22/40 (55%)
		MARK2_C	693..791	CDD:213386	68/97 (70%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	220/251 (88%)
		S_TKc	253..504	CDD:214567	220/250 (88%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	68/96 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	458	1.000	Domainoid score	I486
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	742	1.000	Inparanoid score	I588
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm49044
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060