DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBMY1A1 and dazap1

DIOPT Version :9

Sequence 1:	NP_005049.1	Gene:	RBMY1A1 / 5940	HGNCID:	9912	Length:	496	Species:	Homo sapiens
Sequence 2:	XP_012815264.1	Gene:	dazap1 / 448406	XenbaseID:	XB-GENE-856469	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	445	Identity:	94/445 - (21%)
Similarity:	139/445 - (31%)	Gaps:	188/445 - (42%)

- Green bases have known domain annotations that are detailed below.

Human     3 EADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKD-RTSKSRGFAFITFENPADAKNAAK 66
            |.....|:|:||:.....|..|:..|.:.|.::||::|.| ...:.|||.|||||:......|.
Frog   109 ENSRSNKIFVGGIPHNCGETELREYFKRFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAV- 172

Human    67 DMNGKSLHGKAIKVEQAK-----------KPSFQSGGR-----------RRPPASSRNRSPSGSL 109
            :|:...:.||.::|::|:           ..|.|.|||           :.||...::.||.|.
Frog   173 NMHFHDIMGKKVEVKRAEPRDSKSQTPGPPGSNQWGGRAMQSTANGWTGQPPPTWQQSYSPQGM- 236

Human   110 RSARGSRGGTRGWLPSHEGHL-DDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVAR 173
                        |:|:.:..: ..|||.|                |:.|.|.|||...||..|:.
Frog   237 ------------WMPTGQTIVFSTGGYGP----------------PAGRGGPPPPPSFAPFLVST 273

Human   174 SNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGY 238
            :   .|:..|..      |.||                  ||||               ||..||
Frog   274 T---PGAFPPPQ------GFPP------------------GYAT---------------PPPFGY 296

Human   239 AYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETR 303
            .| .......|:..|.|             .||..|                      .......
Frog   297 GY-GPPPPPPDQFVSSG-------------VPPPPG----------------------TPGAAPL 325

Human   304 EYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPP--HRDYAYRDYGHSSWDEHSSRG 366
            .:.||..|...:|..                        .||  .:|:.:..:|:
Frog   326 AFPPPPPGQSAQDLS------------------------KPPSGQQDFPFSQFGY---------- 356

Human   367 YSYHDGYGEALGRDHSEHLSGSSYRDALQR--YGT-----SHGAPPARGPRMSYG 414
                       |:|.|.:  |.|:.|..|:  |.:     :.|.|||.|..:..|
Frog   357 -----------GQDMSGY--GQSFPDLNQQPPYTSGPSTPASGGPPAGGSGLGRG 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMY1A1	NP_005049.1	RRM	<1..189	CDD:223796	54/209 (26%)
		RRM_RBMX_like	7..85	CDD:240828	26/89 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..349		53/295 (18%)
		RBM1CTR	174..218	CDD:285341	8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..496
dazap1	XP_012815264.1	RRM1_DAZAP1	11..92	CDD:241018
dazap1	XP_012815264.1	RRM2_DAZAP1	112..191	CDD:240773	26/79 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910