DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM4 and SF2

DIOPT Version :9

Sequence 1:	NP_002887.2	Gene:	RBM4 / 5936	HGNCID:	9901	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001247139.1	Gene:	SF2 / 53443	FlyBaseID:	FBgn0283477	Length:	255	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	49/194 - (25%)
Similarity:	85/194 - (43%)	Gaps:	39/194 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKN-----YGFVHIEDKTAAEDAIRNLHHYKLHG 62
            ::::||||.:...::|:.||.::|||...| :||     :.||..||...|:||::....|...|
  Fly     8 RIYVGNLPPDIRTKDIQDLFHKFGKVTFVD-LKNRRGPPFAFVEFEDARDADDAVKARDGYDYDG 71

Human    63 VNINVE------------ASKN----------------KSKTSTKLHVGNISPTCTNKELRAKFE 99
            ..:.||            .::|                ..::..::.|..:..:.:.::|:....
  Fly    72 YRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGPPAKRSQYRVMVTGLPASGSWQDLKDHMR 136

Human   100 EYGPVIECDIVKD-YAFVHMERAEDAVEAIRGLDNTEFQGKRMHV-QLSTSRLRTAPGMGDQSG 161
            |.|.|...|..|| ...|...|.||...||:.||::.|   |.|. :::..|:|...|..|:.|
  Fly   137 EAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLDDSRF---RSHEGEVAYIRVREDSGDNDRGG 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	22/69 (32%)
		RRM2_RBM4	78..144	CDD:410019	19/67 (28%)
		PTZ00368	<145..>181	CDD:173561	5/17 (29%)
		ZnF_C2HC	161..176	CDD:197667	1/1 (100%)
		Interaction with TNPO3. /evidence=ECO:0000269\|PubMed:12628928	196..364
SF2	NP_001247139.1	RRM_SF	3..80	CDD:418427	24/72 (33%)
SF2	NP_001247139.1	RRM2_SRSF1_like	115..188	CDD:410013	20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910