Protein Alignment RBM4 and SF2

DIOPT Version :10

• Sequence 1: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Sequence 2: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Alignment Length: 194
• Identity: 49/194 - (25%)
• Similarity: 85/194 - (43%)
• Gaps: 39/194 - (20%)

Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKN-----YGFVHIEDKTAAEDAIRNLHHYKLHG 62
            ::::||||.:...::|:.||.::|||...| :||     :.||..||...|:||::....|...|
  Fly     8 RIYVGNLPPDIRTKDIQDLFHKFGKVTFVD-LKNRRGPPFAFVEFEDARDADDAVKARDGYDYDG 71

Human    63 VNINVE------------ASKN----------------KSKTSTKLHVGNISPTCTNKELRAKFE 99
            ..:.||            .::|                ..::..::.|..:..:.:.::|:....
  Fly    72 YRLRVEFPRGGGPGSYRGGNRNDRSRDGGGRMGGRGPPAKRSQYRVMVTGLPASGSWQDLKDHMR 136

Human   100 EYGPVIECDIVKD-YAFVHMERAEDAVEAIRGLDNTEFQGKRMHV-QLSTSRLRTAPGMGDQSG 161
            |.|.|...|..|| ...|...|.||...||:.||::.|   |.|. :::..|:|...|..|:.|
  Fly   137 EAGDVCFADTYKDGSGVVEFLRHEDMKYAIKKLDDSRF---RSHEGEVAYIRVREDSGDNDRGG 197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	22/69 (32%)
		RRM2_RBM4	78..144	CDD:410019	19/67 (28%)
		PTZ00368	<145..>181	CDD:173561	5/17 (29%)
		ZnF_C2HC	161..176	CDD:197667	1/1 (100%)
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	24/72 (33%)
		RRM2_SRSF1_like	115..188	CDD:410013	20/75 (27%)