DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM4 and CG7903

DIOPT Version :9

Sequence 1:	NP_002887.2	Gene:	RBM4 / 5936	HGNCID:	9901	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_651755.2	Gene:	CG7903 / 43554	FlyBaseID:	FBgn0039730	Length:	384	Species:	Drosophila melanogaster

Alignment Length:	285	Identity:	66/285 - (23%)
Similarity:	109/285 - (38%)	Gaps:	68/285 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    76 TSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKR 140
            |:.|:.||:: |.|..:|||..|..||.|:|||::...||||:|..:.|..||..|:.|.|:|:.
  Fly     3 TTAKVFVGSL-PRCKPEELRRLFTNYGSVVECDVMNRCAFVHLENTDMAEAAIAALNGTIFKGQP 66

Human   141 MHVQLSTSRL------RTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRT 199
            :.|:....:.      |..||.||..|......:|..:.:.|.:.:   .:....:.|:.|.
  Fly    67 IVVEAGRPKYGPGGGSRGQPGSGDNPGRRPSQVQGGGADKRPHESN---TNFKRNFREEVGG--- 125

Human   200 PYTMSYGDSLYYNNAYGALDAYYKRCRAARSYEAVAAAAASVYNYAEQTLSQLPQVQNTAMASHL 264
                      .::|            ...||..:.||....|.|  |....|    |.:|
  Fly   126 ----------RFSN------------EGPRSSNSSAAKFGPVRN--ESNYRQ----QRSA----- 157

Human   265 TSTSLDPYDRHLLPTSGAAATAAA------AAAAAAAVTAASTSYYGRDRSPLRRATAPVP---- 319
                  ||.:.  |.:..::....      |.......:|.:...:|.:|...|..:.|.|
  Fly   158 ------PYSKG--PPNNESSNQGQGFRNKFAGGGKFGGSAGNEGRFGSNRFQQRDNSGPQPGRRN 214

Human   320 ---TVGEGY-GYGHESELSQASAAA 340
               :...|| |.|:.|:....|:::
  Fly   215 FKNSPTSGYRGGGNNSDFQGGSSSS 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018
		RRM2_RBM4	78..144	CDD:410019	27/65 (42%)
		PTZ00368	<145..>181	CDD:173561	8/41 (20%)
		ZnF_C2HC	161..176	CDD:197667	2/14 (14%)
		Interaction with TNPO3. /evidence=ECO:0000269\|PubMed:12628928	196..364		27/159 (17%)
CG7903	NP_651755.2	RRM	<4..168	CDD:223796	52/211 (25%)
CG7903	NP_651755.2	RRM_SF	6..70	CDD:302621	27/64 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1563362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880