DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM4 and TBPH

DIOPT Version :9

Sequence 1:	NP_002887.2	Gene:	RBM4 / 5936	HGNCID:	9901	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001163280.1	Gene:	TBPH / 37781	FlyBaseID:	FBgn0025790	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	196	Identity:	47/196 - (23%)
Similarity:	77/196 - (39%)	Gaps:	30/196 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDI--------IKNYGFVHIEDKTAAEDAIRNLHHYKL 60
            |.:..||.:.||:.:|..||.||:||...|        .|.:|||......|....:.|.|....
  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDG 173

Human    61 HGVNINVEASKNKS-KTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDY-AFVHMERAE- 122
            ....:.|..||... :...|:.||..:....:.:||..|.::|.|.:..|.:.: ||..:...:
  Fly   174 RWCEVKVPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDP 238

Human   123 DAVEAIRGLDNTEFQGKRMHV-------------QLSTSRLRTAPGMG-----DQSGCYRCGKEG 169
            |..:::.|.|:. .:|..:||             |:.:....:|...|     .|......|:.|
  Fly   239 DVAQSLCGEDHI-IKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNG 302

Human   170 H 170
            |
  Fly   303 H 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	20/71 (28%)
		RRM2_RBM4	78..144	CDD:410019	17/80 (21%)
		PTZ00368	<145..>181	CDD:173561	6/31 (19%)
		ZnF_C2HC	161..176	CDD:197667	3/10 (30%)
		Interaction with TNPO3. /evidence=ECO:0000269\|PubMed:12628928	196..364
TBPH	NP_001163280.1	RRM1_TDP43	108..184	CDD:240767	21/74 (28%)
TBPH	NP_001163280.1	RRM2_TDP43	192..261	CDD:240768	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910