DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR6 and Lgr3

DIOPT Version :10

Sequence 1:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens
Sequence 2:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster


Alignment Length:765 Identity:174/765 - (22%)
Similarity:278/765 - (36%) Gaps:214/765 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   144 RLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQN 208
            ||.:.:.:|:..|:        :|.|.||...        |...||.:||..|.||.:|..:|..
  Fly   153 RLSSEVTNLIIIRN--------NLTLRDNIFA--------NFTRLQKLTLKYNNISRVPLGSFSG 201

Human   209 LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIP 273
            |..|..|.|.:|.:.||....|.|||:|:.|.|..|.|...||        ::|.|...      
  Fly   202 LFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPV--------EQLRFFRR------ 252

Human   274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRA 338
                                                                    ||.|.|:| 
  Fly   253 --------------------------------------------------------LEWLVLSR- 260

Human   339 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 403
                            ..|.|.:.|:.::|:|:      |:.|..|||..||.:|||||.:|..|
  Fly   261 ----------------NRLTLRNVQLPKIPTLY------EVYLDFNRIEYIGEETFSQLDNLHLL 303

Human   404 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG---LMHLKLKGNLALSQA-----F 460
            ||..|.|..||..||:.|.::..:.|..|     |:..|.|   |.:.:|:   |||.|     .
  Fly   304 DLQHNLITHIHGRAFANLTNMRDIRLVGN-----PIKELSGETFLHNTRLE---ALSLALMPIHI 360

Human   461 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASG-QWEAEDLHLDDEE-SSKRPLGLLARQAENHY 523
            |......|.|                ||...:| :::    |:|.|. :|.|.|..:.      |
  Fly   361 SSSLMEPLNI----------------SFLNLTGIRYD----HIDFEAINSMRNLTYII------Y 399

Human   524 DQDLDELQLEMEDSKPHPSVQ-CSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVF 587
            |:   .....|.     |.|: |.|:.......:.|.....:|.:.|.:..|::..|.|||...|
  Fly   400 DR---FFYCSMT-----PRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRF 456

Human   588 AGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLG 652
            ......: .|..|:..:|.|:.|.|.....:...|.....::.:....|.|...|...|.|||..
  Fly   457 IYRDENV-AVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSS 520

Human   653 SEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAG------VLGCLALAGLAAAL-PL----- 705
            ||.|:|:|...:::..:.::       .|..|....|      .|.|:.:.|:..|: |:     
  Fly   521 SEVSMLILAFMSLERFLLIA-------DPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRT 578

Human   706 ASVGEYGA-SPLCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPRGDFEAVW- 767
            :::..||: |..|.|....|..|....::..:.: :|....:::|..|..|..        ::| 
  Fly   579 STLPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLI--------SIWR 635

Human   768 ----------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACL 822
                      ||.......:::..|.|.:.|:..:....... :.::.:....:::.||||.:.:
  Fly   636 TRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFN-YNISDDIYAWLVVFVLPLNSAV 699

Human   823 NPLLYLLFNPHFRDDL---------RRLRPRAGDSGPLAYAAAGELEKSS 863
            |||||....|.:|:.:         .|.|..|| :|.:|....|....||
  Fly   700 NPLLYTFTTPKYRNQIFLRGWKKITSRKRAEAG-NGNVATTTTGTATGSS 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470
LRR <70..>293 CDD:443914 38/148 (26%)
leucine-rich repeat 70..91 CDD:275380
LRR 1 91..112
leucine-rich repeat 92..115 CDD:275380
LRR 2 115..136
leucine-rich repeat 116..139 CDD:275380
LRR 3 139..160 4/15 (27%)
leucine-rich repeat 140..163 CDD:275380 4/18 (22%)
LRR 4 163..186 5/22 (23%)
leucine-rich repeat 164..187 CDD:275380 5/22 (23%)
LRR 5 187..208 9/20 (45%)
leucine-rich repeat 188..211 CDD:275380 10/22 (45%)
LRR 6 211..232 7/20 (35%)
leucine-rich repeat 212..235 CDD:275380 9/22 (41%)
LRR 7 235..256 7/20 (35%)
leucine-rich repeat 236..258 CDD:275380 7/21 (33%)
LRR 8 258..279 2/20 (10%)
leucine-rich repeat 259..282 CDD:275380 2/22 (9%)
LRR_8 281..364 CDD:404697 7/82 (9%)
LRR 9 282..303 0/20 (0%)
leucine-rich repeat 283..304 CDD:275380 0/20 (0%)
LRR 10 306..328 0/21 (0%)
LRR 11 329..350 5/20 (25%)
leucine-rich repeat 330..344 CDD:275378 5/13 (38%)
LRR <349..>473 CDD:443914 42/131 (32%)
LRR 12 353..374 5/20 (25%)
leucine-rich repeat 354..399 CDD:275380 17/44 (39%)
LRR 13 375..396 9/20 (45%)
leucine-rich repeat 376..390 CDD:275378 5/13 (38%)
LRR 14 399..420 10/20 (50%)
leucine-rich repeat 400..423 CDD:275380 11/22 (50%)
LRR 15 423..443 3/19 (16%)
leucine-rich repeat 424..444 CDD:275380 4/19 (21%)
7tmA_LGR6 562..834 CDD:320484 62/296 (21%)
TM helix 1 563..589 CDD:320484 8/25 (32%)
TM helix 2 597..622 CDD:320484 6/24 (25%)
TM helix 3 642..672 CDD:320484 10/29 (34%)
TM helix 4 684..706 CDD:320484 7/33 (21%)
TM helix 5 728..757 CDD:320484 4/29 (14%)
TM helix 6 766..796 CDD:320484 6/40 (15%)
TM helix 7 806..831 CDD:320484 9/24 (38%)
Lgr3NP_733115.1 LDLa 32..65 CDD:238060
LRR 85..389 CDD:443914 91/372 (24%)
leucine-rich repeat 181..204 CDD:275380 10/22 (45%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 9/30 (30%)
leucine-rich repeat 253..275 CDD:275380 8/38 (21%)
leucine-rich repeat 276..299 CDD:275380 13/28 (46%)
leucine-rich repeat 300..323 CDD:275380 11/22 (50%)
leucine-rich repeat 324..347 CDD:275380 6/27 (22%)
7tmA_Relaxin_R 431..715 CDD:320265 63/300 (21%)
TM helix 1 432..458 CDD:320265 8/25 (32%)
TM helix 2 465..490 CDD:320265 6/24 (25%)
TM helix 3 510..540 CDD:320265 10/29 (34%)
TM helix 4 552..574 CDD:320265 5/21 (24%)
TM helix 5 603..632 CDD:320265 4/36 (11%)
TM helix 6 644..674 CDD:320265 5/29 (17%)
TM helix 7 683..708 CDD:320265 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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