DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR6 and Lgr1

DIOPT Version :10

Sequence 1:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens
Sequence 2:NP_524393.2 Gene:Lgr1 / 42133 FlyBaseID:FBgn0016650 Length:831 Species:Drosophila melanogaster


Alignment Length:855 Identity:183/855 - (21%)
Similarity:331/855 - (38%) Gaps:205/855 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    85 LFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG-IPAEALWEL-------PSLQ 141
            |.|||....   |||.|.          :|:       .:.:|| :.|....::       |:|.
  Fly    33 LLHHLLLTS---LSGRHF----------VYA-------TSAVGGALSANNCHDIHHGFDVYPNLT 77

Human   142 SLRL----DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR----ALNNLPALQAMTLALNRI 198
            ::.|    |..|.:.:|..:::..     .|...|...|:..|    .||.:|  |.:||.:.| 
  Fly    78 AVSLAQSTDTPLTATMPRSAWKCC-----CWNASNQAEEVECRCEGDGLNRVP--QTLTLPIQR- 134

Human   199 SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELG 263
                         |.:......|::|.|..    ::....||:.:....:               
  Fly   135 -------------LTIASAGLPRLRHTGLK----VYGSTLLDVAFTDCLQ--------------- 167

Human   264 FHNNNIKAIPEKAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 327
                 ::.|.:.||....||:||:..:.| :.|:.:..|        |.::..:||         
  Fly   168 -----LELIQDGAFANLTLLRTIYITNAPKLTFLSKDVF--------LGISDTVDI--------- 210

Human   328 TSLEILTLTRAGIRLLPSGMCQ-----QLPR---LRVLELSHNQIEELPSLHRCQKLEEIGLQHN 384
                        ||::.||:.:     .||.   |::::|.:|||..:.|.....|..::.|.:|
  Fly   211 ------------IRIINSGLTRVPDLGHLPPHNILQMIDLDNNQITRIDSKSIKVKTAQLILTNN 263

Human   385 RIWEIGADTFSQLSSLQALDLSWN-AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 448
            .|..:....|.. |.:..|.|..| .::.:||.||..:..:.:|||:...|..||.|||..:..|
  Fly   264 EISYVDDSAFFG-SKIAKLSLKENKKLQMMHPNAFDGIIDITELDLSSTSLVGLPSAGLQNIEAL 327

Human   449 KLKGNLALSQAFSKDSFPKLRILEVPYAYQCC--------------------------------- 480
            .::....|....|..:|..|:...:.:::.||                                 
  Fly   328 YIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAFQFPSRHDPQRHAQRMLEIEKWRKQCKSDSGT 392

Human   481 ---------PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLE--- 533
                     |:.|...|....|        .||..:...|:...:      :|...|:...:   
  Fly   393 RKERSTLDNPFNMPEDFGSFGG--------TDDSATDITPITFAS------FDYMADDTMNKGTF 443

Human   534 --------MEDSKPH---------PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL 581
                    .:||...         |:::|.|.|....|||.:.....:|::||.:|.|:|:.|..
  Fly   444 HEKIILNPGDDSSAELCGNFTFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVA 508

Human   582 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATG 646
            ||..:.:..|...|..:|::..:|.|:...|:...|:|.:||.:.|::..:...|:.||||:..|
  Fly   509 VLTVILSIRPESTPVPRFLMCHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAG 573

Human   647 FLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEY 711
            ||.|..|..||..||:..::..::::..........|......:||....:.|.::|||..:..|
  Fly   574 FLTVFASHLSVFTLTVITIERWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNY 638

Human   712 GASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA----VWDCAMV 772
            .::.:|||....:.....  :.:|::..|...|.::|..|.::|..|.|...:|    ..:.::.
  Fly   639 SSTSICLPMENRDVYDTI--YLIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVA 701

Human   773 RHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVL-PLPACLNPLLYLLFNPHFRD 836
            :.:|.|:|.:...:.|:||....::.| :|:.......:|||.. ||.:|.:|.||.:....:|.
  Fly   702 KKMALLVFTNFACWSPIAFFGLTALAG-YPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQ 765

Human   837 DLRRLRPRAG 846
            ||..|..:.|
  Fly   766 DLFTLLSKLG 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470
LRR <70..>293 CDD:443914 43/224 (19%)
leucine-rich repeat 70..91 CDD:275380 4/5 (80%)
LRR 1 91..112 4/20 (20%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR 2 115..136 3/21 (14%)
leucine-rich repeat 116..139 CDD:275380 3/30 (10%)
LRR 3 139..160 5/24 (21%)
leucine-rich repeat 140..163 CDD:275380 5/26 (19%)
LRR 4 163..186 6/26 (23%)
leucine-rich repeat 164..187 CDD:275380 6/26 (23%)
LRR 5 187..208 4/20 (20%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
LRR 6 211..232 4/20 (20%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
LRR 7 235..256 2/20 (10%)
leucine-rich repeat 236..258 CDD:275380 2/21 (10%)
LRR 8 258..279 3/20 (15%)
leucine-rich repeat 259..282 CDD:275380 3/22 (14%)
LRR_8 281..364 CDD:404697 19/91 (21%)
LRR 9 282..303 7/21 (33%)
leucine-rich repeat 283..304 CDD:275380 6/21 (29%)
LRR 10 306..328 3/21 (14%)
LRR 11 329..350 4/25 (16%)
leucine-rich repeat 330..344 CDD:275378 2/13 (15%)
LRR <349..>473 CDD:443914 35/132 (27%)
LRR 12 353..374 6/23 (26%)
leucine-rich repeat 354..399 CDD:275380 11/44 (25%)
LRR 13 375..396 5/20 (25%)
leucine-rich repeat 376..390 CDD:275378 3/13 (23%)
LRR 14 399..420 7/21 (33%)
leucine-rich repeat 400..423 CDD:275380 7/23 (30%)
LRR 15 423..443 8/19 (42%)
leucine-rich repeat 424..444 CDD:275380 9/19 (47%)
7tmA_LGR6 562..834 CDD:320484 71/276 (26%)
TM helix 1 563..589 CDD:320484 9/25 (36%)
TM helix 2 597..622 CDD:320484 6/24 (25%)
TM helix 3 642..672 CDD:320484 10/29 (34%)
TM helix 4 684..706 CDD:320484 5/21 (24%)
TM helix 5 728..757 CDD:320484 6/28 (21%)
TM helix 6 766..796 CDD:320484 6/29 (21%)
TM helix 7 806..831 CDD:320484 9/25 (36%)
Lgr1NP_524393.2 LRR <162..>354 CDD:443914 52/241 (22%)
leucine-rich repeat 182..207 CDD:275380 7/32 (22%)
leucine-rich repeat 208..231 CDD:275380 8/43 (19%)
leucine-rich repeat 233..256 CDD:275380 7/22 (32%)
leucine-rich repeat 257..277 CDD:275380 4/20 (20%)
leucine-rich repeat 278..302 CDD:275380 7/23 (30%)
leucine-rich repeat 303..323 CDD:275380 9/19 (47%)
leucine-rich repeat 324..346 CDD:275380 4/21 (19%)
7tmA_Glyco_hormone_R 490..767 CDD:320264 72/279 (26%)
TM helix 1 490..516 CDD:320264 9/25 (36%)
TM helix 2 524..549 CDD:320264 6/24 (25%)
TM helix 3 569..599 CDD:320264 10/29 (34%)
TM helix 4 611..633 CDD:320264 5/21 (24%)
TM helix 5 653..682 CDD:320264 6/30 (20%)
TM helix 6 692..725 CDD:320264 6/32 (19%)
TM helix 7 735..760 CDD:320264 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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