DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR6 and Toll-6

DIOPT Version :10

Sequence 1:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens
Sequence 2:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:587 Identity:143/587 - (24%)
Similarity:234/587 - (39%) Gaps:144/587 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    27 QPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRF 91
            :|..|.|...:.....:.....|..||.        ||:    |||:|.|:...|....|..||.
  Fly   250 EPTNGSTESTSTTESAKKSSSSSTSCSL--------DLE----YLDVSHNDFVVLPANGFGTLRR 302

Human    92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPS-LQSLRLDANLISLVPE 155
            |..|.::.|.:|.|..:|.|||.:|:||.|.:|::..:|.|...|... :|.:.|..|.||::..
  Fly   303 LRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNP 367

Human   156 RSFEGLSSLRHLWLDDNALTE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLH 218
            :.|..|..|:.|.|..|.:|.  |.......|..|..:.|:.|:::.:....|.:|.:|.:|:|.
  Fly   368 QLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLR 432

Human   219 NNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-------------------------PVAIRTLGR 258
            :|:::::...:|..::||.||.|::|||:..                         |.|.|....
  Fly   433 HNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSA 497

Human   259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQ 319
            ||:|..:.|.:|.:| .|......|:|:...:|.|..:..|||:.|..|:.|.|.|    .:.:.
  Fly   498 LQDLNLNGNQLKTVP-LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMH 561

Human   320 EFPDLKGTTSLEILTLTRAGIRLLP-----------------------SGMCQQLPRLRVLELSH 361
            .|.||   .:|:||.|.|..|.::.                       :|:...:|.|..|.:|.
  Fly   562 TFRDL---PNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISD 623

Human   362 NQIEELPSLHRCQKLEEIGLQHNRIWEI----GAD----------TFSQL---------SSLQAL 403
            |::|.....|....|:.:.|..||:..:    |.|          :|:||         :|::.|
  Fly   624 NRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELL 688

Human   404 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL--------GGLMHLKLKGN------- 453
            .|:.|.|.::.|:.|....:|.::||..||:|||.:..|        ..|....:.||       
  Fly   689 FLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCN 753

Human   454 ---LALSQAFSKDSFPKLRILEVPY---------AY-----------------------QCCPYG 483
               |......:...:|::..||..|         ||                       .||.:.
  Fly   754 IDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFD 818

Human   484 MC 485
            .|
  Fly   819 AC 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470 5/33 (15%)
LRR <70..>293 CDD:443914 71/250 (28%)
leucine-rich repeat 70..91 CDD:275380 8/20 (40%)
LRR 1 91..112 6/20 (30%)
leucine-rich repeat 92..115 CDD:275380 9/22 (41%)
LRR 2 115..136 7/20 (35%)
leucine-rich repeat 116..139 CDD:275380 8/22 (36%)
LRR 3 139..160 6/21 (29%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
LRR 4 163..186 6/24 (25%)
leucine-rich repeat 164..187 CDD:275380 7/24 (29%)
LRR 5 187..208 4/20 (20%)
leucine-rich repeat 188..211 CDD:275380 5/22 (23%)
LRR 6 211..232 5/20 (25%)
leucine-rich repeat 212..235 CDD:275380 5/22 (23%)
LRR 7 235..256 11/45 (24%)
leucine-rich repeat 236..258 CDD:275380 10/46 (22%)
LRR 8 258..279 7/20 (35%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
LRR_8 281..364 CDD:404697 27/109 (25%)
LRR 9 282..303 7/20 (35%)
leucine-rich repeat 283..304 CDD:275380 7/20 (35%)
LRR 10 306..328 7/25 (28%)
LRR 11 329..350 7/43 (16%)
leucine-rich repeat 330..344 CDD:275378 6/13 (46%)
LRR <349..>473 CDD:443914 38/164 (23%)
LRR 12 353..374 6/20 (30%)
leucine-rich repeat 354..399 CDD:275380 15/67 (22%)
LRR 13 375..396 7/34 (21%)
leucine-rich repeat 376..390 CDD:275378 4/17 (24%)
LRR 14 399..420 7/20 (35%)
leucine-rich repeat 400..423 CDD:275380 6/22 (27%)
LRR 15 423..443 9/27 (33%)
leucine-rich repeat 424..444 CDD:275380 9/27 (33%)
7tmA_LGR6 562..834 CDD:320484
TM helix 1 563..589 CDD:320484
TM helix 2 597..622 CDD:320484
TM helix 3 642..672 CDD:320484
TM helix 4 684..706 CDD:320484
TM helix 5 728..757 CDD:320484
TM helix 6 766..796 CDD:320484
TM helix 7 806..831 CDD:320484
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380 6/35 (17%)
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380 9/26 (35%)
LRR 299..654 CDD:443914 94/358 (26%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
leucine-rich repeat 402..425 CDD:275380 5/22 (23%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 3/22 (14%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 8/22 (36%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 1/21 (5%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 6/23 (26%)
LRR_8 662..719 CDD:404697 14/56 (25%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 8/18 (44%)
LRR <863..>990 CDD:443914
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
Blue background indicates that the domain is not in the aligned region.

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