Protein Alignment LGR6 and Con

DIOPT Version :10

• Sequence 1: NP_001017403.1
• Gene: LGR6 / 59352
• HGNCID: 19719
• Length: 967
• Species: Homo sapiens
• Sequence 2: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 100/374 - (26%)
• Similarity: 158/374 - (42%)
• Gaps: 66/374 - (17%)

Human    39 CHCQEDG---IMLSADC---SELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRL 97
            |:|..|.   .:..|:|   ||                 .|..|:.|..:   |:..:.|.||:.
  Fly   119 CYCTPDENHVPVQKAECWVFSE-----------------GLHQNDTTWTR---FYQQKRLRELKF 163

Human    98 ---SGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFE 159
               :...|.:||......|.:|..::::.:|:..:.:.|...||.|:.:.|:.|.|..:.:.:|.
  Fly   164 VIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFA 228

Human   160 GLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH 224
            ....||.|.|:.|.:.|:...|..|||..:.:.|..|.||.:.:..|.::..|..|:|.:|:|..
  Fly   229 NHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINV 293

Human   225 LGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288
            |.:..|.||.||..|.|..|.|... ......|..|.||...:|.|:.|.|:|..|...|:|::.
  Fly   294 LTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNL 358

Human   289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT----------LTRAGIRLL 343
            .:|.::.:.....:..|.|  ||:|    :|       ...||.||          |..:...||
  Fly   359 RNNLLKKIDNGLLRGTPAL--LSIN----VQ-------ANKLETLTFYTFQPIMDNLVNSTSELL 410

Human   344 PSG---MCQQLPRLR-VLELS----HNQI-EELPSLHRCQKLEEIGLQH 383
            .|.   :|.  .||: :.||.    |.|: :.|..|| | .|:|..|.|
  Fly   411 VSDNKFICD--CRLQWIFELKNRTRHLQLRDSLEDLH-C-TLQEPKLSH 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	7/34 (21%)
		LRR	<70..>293	CDD:443914	64/226 (28%)
		leucine-rich repeat	70..91	CDD:275380	4/20 (20%)
		LRR 1	91..112		6/23 (26%)
		leucine-rich repeat	92..115	CDD:275380	7/25 (28%)
		LRR 2	115..136		3/20 (15%)
		leucine-rich repeat	116..139	CDD:275380	4/22 (18%)
		LRR 3	139..160		5/20 (25%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		LRR 4	163..186		8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR 5	187..208		5/20 (25%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		LRR 6	211..232		7/20 (35%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		LRR 7	235..256		6/21 (29%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR 8	258..279		8/20 (40%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		LRR_8	281..364	CDD:404697	23/100 (23%)
		LRR 9	282..303		3/20 (15%)
		leucine-rich repeat	283..304	CDD:275380	3/20 (15%)
		LRR 10	306..328		5/21 (24%)
		LRR 11	329..350		9/33 (27%)
		leucine-rich repeat	330..344	CDD:275378	6/23 (26%)
		LRR	<349..>473	CDD:443914	14/41 (34%)
		LRR 12	353..374		9/26 (35%)
		leucine-rich repeat	354..399	CDD:275380	13/36 (36%)
		LRR 13	375..396		4/9 (44%)
		leucine-rich repeat	376..390	CDD:275378	4/8 (50%)
		LRR 14	399..420
		leucine-rich repeat	400..423	CDD:275380
		LRR 15	423..443
		leucine-rich repeat	424..444	CDD:275380
		7tmA_LGR6	562..834	CDD:320484
		TM helix 1	563..589	CDD:320484
		TM helix 2	597..622	CDD:320484
		TM helix 3	642..672	CDD:320484
		TM helix 4	684..706	CDD:320484
		TM helix 5	728..757	CDD:320484
		TM helix 6	766..796	CDD:320484
		TM helix 7	806..831	CDD:320484
Con	NP_523930.3	LRR	<157..459	CDD:443914	89/316 (28%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)