DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR6 and rk

DIOPT Version :10

Sequence 1:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:979 Identity:298/979 - (30%)
Similarity:454/979 - (46%) Gaps:141/979 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    39 CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103
            |||.....:|...|..:|:.|||.:|......|||..||||:|:...|.....||||.||.|.:.
  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216

Human   104 HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN-LISLVPERSFEG-----LS 162
            ::...||.||..||.|.|||..|..:|.::...|..|.||:|:.| |:||      :|     |.
  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL------DGDCLGHLQ 275

Human   163 SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT 227
            .||.|.|:.|....||..||..|..|:|:.|..|.::.|.|..|..:.:|:||.|..|:|..:..
  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA 340

Human   228 HSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292
            .:.:.|..|:.|:|:.|.:...|..:..|.:||||...:|.::.|.:.....:  :|.:....||
  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRS--MQMLDMRANP 403

Human   293 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357
            :..:...||:.:.||..|.|:....::.||:|:...:||||.|.||||:.:|:.:|:|.|||:.|
  Fly   404 LSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468

Human   358 ELSHNQIEELPSLHRC------------------------QKLEEIGLQHNRIWEIGADTFSQLS 398
            ||..|.::.:|:|..|                        ::|.::.|.:|||..:..|.|..:.
  Fly   469 ELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533

Human   399 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463
            .||.|||..|.|..||.||||...:|..|:|.:|....||.:||..|:|||...|..|.:....|
  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPD 598

Human   464 SFPKLRILEVPYAYQCC---PYGMCASFFKAS--------------------------------- 492
            :||:::.|.:.|||.||   |....:|..|.|                                 
  Fly   599 TFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663

Human   493 ---------GQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDE--------------LQLEM 534
                     ..||.. ::.::|:...:..|.:|......|.::.|.              ..:..
  Fly   664 SKQLGASMHDPWETA-INFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMST 727

Human   535 EDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAG-GPVPLPPVK 598
            ||.:| .||||.|.||||.||..||:.|.:|..||.:.|||:|.||.|:..:... ..:.:|  :
  Fly   728 EDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVP--R 789

Human   599 FVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLA 663
            |:|..:|.|:...||..|:||.|||.|.|:|..:...|:..:.|:.:||||||.||.||  .|||
  Fly   790 FLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSV--YTLA 852

Human   664 AVQCSVSVSCVRAYGKSPSLGSVRAGVLGCL--ALAGLAAALPLASVGEYGASPLCLPYAPPEGQ 726
            .:....:.:...|...:..|...:||.:..:  ..|.:.|.:||..|.:|....:|||:....| 
  Fly   853 VITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTG- 916

Human   727 PAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW---DCAMVRHVAWLIFADGLLYCP 788
            ||:|.:.::|:.:|...||.:.|.|:|:|..: ||  ...|   |..:.:.:|.|:|.|.|.:.|
  Fly   917 PASLTYVISLMFINGCAFLTLMGCYLKMYWAI-RG--SQAWNTNDSRIAKRMALLVFTDFLCWSP 978

Human   789 VAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPR------AGD 847
            :||.|..::.||..::.|..|...:.||||.:|.||.||.:....|:.|...|...      .|.
  Fly   979 IAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGG 1043

Human   848 SGPLAYAAAGELEKSSCDSTQALVAFSDVDL---ILEASEAGRPPGLETYGFPSVTLISCQQPGA 909
            .||....|....::.              ||   :|.|:....|||..     .:.::..:.|..
  Fly  1044 GGPGGRGAVARTKRG--------------DLPPPLLPAAAVAHPPGCR-----CLRMLPSEMPNW 1089

Human   910 PRLE 913
            .::|
  Fly  1090 HKME 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470 10/28 (36%)
LRR <70..>293 CDD:443914 77/228 (34%)
leucine-rich repeat 70..91 CDD:275380 9/20 (45%)
LRR 1 91..112 9/20 (45%)
leucine-rich repeat 92..115 CDD:275380 11/22 (50%)
LRR 2 115..136 8/20 (40%)
leucine-rich repeat 116..139 CDD:275380 9/22 (41%)
LRR 3 139..160 8/21 (38%)
leucine-rich repeat 140..163 CDD:275380 10/28 (36%)
LRR 4 163..186 9/22 (41%)
leucine-rich repeat 164..187 CDD:275380 10/22 (45%)
LRR 5 187..208 7/20 (35%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
LRR 6 211..232 6/20 (30%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
LRR 7 235..256 5/20 (25%)
leucine-rich repeat 236..258 CDD:275380 6/21 (29%)
LRR 8 258..279 6/20 (30%)
leucine-rich repeat 259..282 CDD:275380 6/22 (27%)
LRR_8 281..364 CDD:404697 31/82 (38%)
LRR 9 282..303 5/20 (25%)
leucine-rich repeat 283..304 CDD:275380 5/20 (25%)
LRR 10 306..328 7/21 (33%)
LRR 11 329..350 11/20 (55%)
leucine-rich repeat 330..344 CDD:275378 9/13 (69%)
LRR <349..>473 CDD:443914 49/147 (33%)
LRR 12 353..374 9/44 (20%)
leucine-rich repeat 354..399 CDD:275380 15/68 (22%)
LRR 13 375..396 7/20 (35%)
leucine-rich repeat 376..390 CDD:275378 5/13 (38%)
LRR 14 399..420 12/20 (60%)
leucine-rich repeat 400..423 CDD:275380 13/22 (59%)
LRR 15 423..443 7/19 (37%)
leucine-rich repeat 424..444 CDD:275380 8/19 (42%)
7tmA_LGR6 562..834 CDD:320484 93/277 (34%)
TM helix 1 563..589 CDD:320484 10/25 (40%)
TM helix 2 597..622 CDD:320484 9/24 (38%)
TM helix 3 642..672 CDD:320484 14/29 (48%)
TM helix 4 684..706 CDD:320484 5/23 (22%)
TM helix 5 728..757 CDD:320484 10/28 (36%)
TM helix 6 766..796 CDD:320484 11/32 (34%)
TM helix 7 806..831 CDD:320484 11/24 (46%)
rkNP_476702.1 LRR <157..390 CDD:443914 82/238 (34%)
leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
leucine-rich repeat 183..204 CDD:275380 9/20 (45%)
leucine-rich repeat 205..228 CDD:275380 11/22 (50%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
leucine-rich repeat 253..276 CDD:275380 10/28 (36%)
leucine-rich repeat 277..300 CDD:275380 10/22 (45%)
LRR 292..612 CDD:443914 102/321 (32%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 6/20 (30%)
leucine-rich repeat 394..415 CDD:275380 5/20 (25%)
leucine-rich repeat 418..486 CDD:275380 28/67 (42%)
leucine-rich repeat 441..464 CDD:275378 12/22 (55%)
leucine-rich repeat 487..510 CDD:275380 0/22 (0%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
leucine-rich repeat 535..558 CDD:275380 13/22 (59%)
leucine-rich repeat 559..580 CDD:275380 8/20 (40%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 94/281 (33%)
TM helix 1 755..781 CDD:320264 10/25 (40%)
TM helix 2 788..813 CDD:320264 10/26 (38%)
TM helix 3 833..863 CDD:320264 14/31 (45%)
TM helix 4 875..897 CDD:320264 5/21 (24%)
TM helix 5 918..947 CDD:320264 10/28 (36%)
TM helix 6 956..986 CDD:320264 10/29 (34%)
TM helix 7 996..1021 CDD:320264 11/24 (46%)

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