Protein Alignment RXFP1 and CG18249

DIOPT Version :10

• Sequence 1: NP_001240656.1
• Gene: RXFP1 / 59350
• HGNCID: 19718
• Length: 784
• Species: Homo sapiens
• Sequence 2: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 349
• Identity: 86/349 - (24%)
• Similarity: 134/349 - (38%)
• Gaps: 93/349 - (26%)

Human   144 NLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYL 208
            :||.|    .|:|::.:|...:..|....|.....|:.|.|..|.|.::.:.||:||:.|..|.|
  Fly    98 SLRPV----ENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRLLGL 158

Human   209 SHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 273
            ..|.|..:.....:.|..|..|.:..|.|:.: |...:..|..:..:|:|....|:....:...:
  Fly   159 QGNAIAEILSSTLDPLMELVHLDLSRNELTTL-PQNIFAKNKKLQTLLLNGNPLRILMPDVLGSL 222

Human   274 PRLHWLDLEGN---------HIHNLRNLTFISCSNLTVLVMR---------KNKINH-------- 312
            |.|..||| |:         ::.|::||. :..|:|:.||:.         .|::||
  Fly   223 PNLRLLDL-GHAAELEVMTLNLTNVQNLV-LEGSSLSSLVINGGFIKLQAGNNELNHLQVGNKSS 285

Human   313 ----------LNENTFAPLQK----LDELDLGSNKIENLPP-------------LIFKDLK---- 346
                      ||.|..|.|.:    |..|||..|:||.||.             ||...||
  Fly   286 VIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDASGTQELLILPSLKFLNL 350

Human   347 -----------------ELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQ-QRMFRPL 393
                             .||.|:||:|.:..:.......|..||.|.:||..::.|. |::....
  Fly   351 ANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLYVEGNRLNTINYQKLHEEH 415

Human   394 MNLSH-----------IYFKKFQY 406
            .:||.           :|.|.|.|
  Fly   416 PDLSELGLHDNPWSSGLYRKMFLY 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RXFP1	NP_001240656.1	LDLa	27..62	CDD:238060
		leucine-rich repeat	155..178	CDD:275380	4/22 (18%)
		LRR	<173..>387	CDD:443914	72/288 (25%)
		leucine-rich repeat	179..202	CDD:275380	9/22 (41%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..250	CDD:275380	5/22 (23%)
		leucine-rich repeat	251..275	CDD:275380	3/23 (13%)
		leucine-rich repeat	276..299	CDD:275380	8/31 (26%)
		leucine-rich repeat	300..323	CDD:275380	11/49 (22%)
		leucine-rich repeat	324..347	CDD:275380	13/56 (23%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		leucine-rich repeat	372..393	CDD:275380	7/21 (33%)
		7tmA_RXFP1_LGR7	433..719	CDD:320631
		TM helix 1	434..460	CDD:320631
		TM helix 2	467..492	CDD:320631
		TM helix 3	512..542	CDD:320631
		TM helix 4	553..575	CDD:320631
		TM helix 5	603..632	CDD:320631
		TM helix 6	648..678	CDD:320631
		TM helix 7	687..712	CDD:320631
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380
		LRR	105..433	CDD:443914	78/330 (24%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		leucine-rich repeat	129..152	CDD:275380	9/22 (41%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		leucine-rich repeat	177..200	CDD:275380	6/23 (26%)
		leucine-rich repeat	201..224	CDD:275380	3/22 (14%)
		leucine-rich repeat	225..258	CDD:275380	10/34 (29%)
		leucine-rich repeat	259..310	CDD:275380	10/50 (20%)
		leucine-rich repeat	311..344	CDD:275380	11/32 (34%)
		leucine-rich repeat	345..368	CDD:275380	2/22 (9%)
		leucine-rich repeat	369..390	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	7/23 (30%)