Protein Alignment RXFP1 and Toll-6

DIOPT Version :10

• Sequence 1: NP_001240656.1
• Gene: RXFP1 / 59350
• HGNCID: 19718
• Length: 784
• Species: Homo sapiens
• Sequence 2: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Alignment Length: 399
• Identity: 108/399 - (27%)
• Similarity: 168/399 - (42%)
• Gaps: 104/399 - (26%)

Human   135 GLELDCDET-----NLRAVPSVSSNVTAMS---------------LQWNLIRKLPPDCFKNYHDL 179
            |:.:..|:.     ||:.:...|:.:.|:.               ||.|.|..|.|..|.|...|
  Fly   312 GISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQL 376

Human   180 QKLYLQNNKITS--ISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISP 242
            |.|.|..|:|||  |....|.||..|..|.||||::|.|:|.:|.||:.|:.|.:..|.|..|:.
  Fly   377 QALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAA 441

Human   243 PTF---------------------YGLNSLILLVLM---NNVLTRL-PDKPLCQHMPRLHWLDLE 282
            .||                     |.||.|.:|.|:   ||.|..: ||  ..::...|..|:|.
  Fly   442 DTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPD--AFRNCSALQDLNLN 504

Human   283 GNHIHN----LRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFK 343
            ||.:..    |||:     .:|..:.:.:|.|..:.::.|..|..|..|.|..|.:||:....|:
  Fly   505 GNQLKTVPLALRNM-----RHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFR 564

Human   344 DLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPL-----MNLSHIYFKK 403
            ||..|..|||:.|.|..::...|:....::::.|:|.|:::| ..:|..:     :|:|....:.
  Fly   565 DLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLES 628

Human   404 FQYCGYAPHVRSCKPNTDGISSLE------NLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRS 462
            |.| |:.|            |:|:      |.|:|:..|           ||          :.|
  Fly   629 FDY-GHVP------------STLQWLDLHKNRLSSLSNR-----------FG----------LDS 659

Human   463 ENKLYAMSI 471
            |.||..:.:
  Fly   660 ELKLQTLDV 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RXFP1	NP_001240656.1	LDLa	27..62	CDD:238060
		leucine-rich repeat	155..178	CDD:275380	9/37 (24%)
		LRR	<173..>387	CDD:443914	77/244 (32%)
		leucine-rich repeat	179..202	CDD:275380	12/24 (50%)
		leucine-rich repeat	203..226	CDD:275380	12/22 (55%)
		leucine-rich repeat	227..250	CDD:275380	9/43 (21%)
		leucine-rich repeat	251..275	CDD:275380	8/27 (30%)
		leucine-rich repeat	276..299	CDD:275380	8/26 (31%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		7tmA_RXFP1_LGR7	433..719	CDD:320631	7/39 (18%)
		TM helix 1	434..460	CDD:320631	3/25 (12%)
		TM helix 2	467..492	CDD:320631	0/5 (0%)
		TM helix 3	512..542	CDD:320631
		TM helix 4	553..575	CDD:320631
		TM helix 5	603..632	CDD:320631
		TM helix 6	648..678	CDD:320631
		TM helix 7	687..712	CDD:320631
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..201	CDD:275380
		LRR_8	200..>246	CDD:404697
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		LRR	299..654	CDD:443914	101/362 (28%)
		leucine-rich repeat	303..326	CDD:275380	2/13 (15%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	12/24 (50%)
		leucine-rich repeat	402..425	CDD:275380	12/22 (55%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	4/22 (18%)
		leucine-rich repeat	474..497	CDD:275380	7/24 (29%)
		leucine-rich repeat	498..518	CDD:275380	7/19 (37%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	7/22 (32%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	6/33 (18%)
		leucine-rich repeat	638..662	CDD:275380	9/44 (20%)
		LRR_8	662..719	CDD:404697	2/7 (29%)
		leucine-rich repeat	663..684	CDD:275380	1/6 (17%)
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR	<863..>990	CDD:443914
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587