Protein Alignment RXFP1 and CG4168

DIOPT Version :10

• Sequence 1: NP_001240656.1
• Gene: RXFP1 / 59350
• HGNCID: 19718
• Length: 784
• Species: Homo sapiens
• Sequence 2: NP_609740.4
• Gene: CG4168 / 34889
• FlyBaseID: FBgn0028888
• Length: 1330
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 70/356 - (19%)
• Similarity: 130/356 - (36%)
• Gaps: 98/356 - (27%)

Human    73 YNGFQE--NGDY--------NKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHH 127
            ||..::  ..||        .:||..:.:..||.:::  ..||..::.:.:..|.:..|  |.
  Fly   736 YNNGEDLIGKDYLWRVITAGQEPIAHRAINILNEMMT--VGPRQLSEMKAYHESFIEEC--CE-- 794

Human   128 QTTKIKQLAAF-----------TPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQ 181
                 |..|.|           :|:...:...|.|..|..|..:.::||..:...| ||:..:|:
  Fly   795 -----KLRAMFQSMEMLLREFPSPKPVSKKGNEKESSRKKLLLVDQMCRMIRTLQE-YIRECDRK 853

Human   182 LR----ALLLSHQFRRREAD-----QAHGQSFS-------SSAVKAPFQVILLRALAFL------ 224
            ..    ||.|.|..|.|:.:     |..|:...       |:.....|:..|||.:..|
  Fly   854 YPGDRFALPLCHAVRGRQVELIVKFQTPGRQLDDIELLSHSNETMHSFKRNLLRRIKVLKANEIR 918

Human   225 -------------------ACAFLLFTTLYGPSEPFTPGAALPP---ALPPGGNSSAASDNTT-- 265
                               ..||      ||..:..:..|.|.|   .|...|:..::|::::
  Fly   919 VDLYDNGTNELIMVPDDQQTLAF------YGIRDKMSLIAKLTPVSSGLMAAGSPDSSSESSSGS 977

Human   266 -----SQAEGWQQLLGLL----PEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLR 321
                 |.:|....|.|::    |:: |:...:.:....:.:...:..|:.: ||.:|...|:.:.
  Fly   978 PPRNYSASESEDTLPGVVIAQKPQY-TQFFLQVYQLANALEHDRLRDGVRS-LLHLLPLDRMTVN 1040

Human   322 RI-DAFSTCLWALLLGLHLA-EHYLQAASPG 350
            .: :.|:|...|:.....:| |.|:.|...|
  Fly  1041 NLYEVFNTAQGAIEDARKVAMEAYMAARESG 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RXFP1	NP_001240656.1	LDLa	27..62	CDD:238060
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR	<173..>387	CDD:443914	46/235 (20%)
		leucine-rich repeat	179..202	CDD:275380	8/31 (26%)
		leucine-rich repeat	203..226	CDD:275380	6/54 (11%)
		leucine-rich repeat	227..250	CDD:275380	7/25 (28%)
		leucine-rich repeat	251..275	CDD:275380	5/30 (17%)
		leucine-rich repeat	276..299	CDD:275380	3/26 (12%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	324..347	CDD:275380	6/23 (26%)
		leucine-rich repeat	348..371	CDD:275380	1/3 (33%)
		leucine-rich repeat	372..393	CDD:275380
		7tmA_RXFP1_LGR7	433..719	CDD:320631
		TM helix 1	434..460	CDD:320631
		TM helix 2	467..492	CDD:320631
		TM helix 3	512..542	CDD:320631
		TM helix 4	553..575	CDD:320631
		TM helix 5	603..632	CDD:320631
		TM helix 6	648..678	CDD:320631
		TM helix 7	687..712	CDD:320631
CG4168	NP_609740.4	PRK15370	<69..>353	CDD:185268
		leucine-rich repeat	99..118	CDD:275380
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR	<338..651	CDD:443914
		leucine-rich repeat	339..365	CDD:275380
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		leucine-rich repeat	414..436	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		leucine-rich repeat	460..483	CDD:275380
		leucine-rich repeat	484..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..589	CDD:275380
		LRR	543..971	CDD:443914	50/252 (20%)
		leucine-rich repeat	590..613	CDD:275380
		leucine-rich repeat	614..639	CDD:275380
		leucine-rich repeat	640..663	CDD:275380
		leucine-rich repeat	664..687	CDD:275380
		leucine-rich repeat	688..711	CDD:275380
		leucine-rich repeat	712..735	CDD:275380
		leucine-rich repeat	740..783	CDD:275380	8/44 (18%)
		leucine-rich repeat	785..808	CDD:275380	6/31 (19%)
		leucine-rich repeat	809..832	CDD:275380	5/22 (23%)
		leucine-rich repeat	833..856	CDD:275380	6/23 (26%)
		leucine-rich repeat	857..879	CDD:275380	6/21 (29%)
		leucine-rich repeat	880..900	CDD:275380	2/19 (11%)
		leucine-rich repeat	905..928	CDD:275380	4/22 (18%)
		LRR	911..>1203	CDD:443914	30/169 (18%)
		leucine-rich repeat	929..952	CDD:275380	4/28 (14%)
		leucine-rich repeat	953..977	CDD:275380	5/23 (22%)
		leucine-rich repeat	978..1020	CDD:275380	6/42 (14%)
		leucine-rich repeat	1045..1068	CDD:275380	6/22 (27%)
		leucine-rich repeat	1069..1090	CDD:275380	1/3 (33%)
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
		PCC	1230..>1298	CDD:188093