DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF350 and LOC100487768

DIOPT Version :9

Sequence 1:	XP_016882583.1	Gene:	ZNF350 / 59348	HGNCID:	16656	Length:	574	Species:	Homo sapiens
Sequence 2:	XP_031746881.1	Gene:	LOC100487768 / 100487768	-ID:	-	Length:	477	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	143/491 - (29%)
Similarity:	195/491 - (39%)	Gaps:	152/491 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     8 ITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDAL-----------FKLE 61
            ||..||::.|:.:||..: ...|:||:|:| |.|.|..||.....:...:           ...|
Frog   105 ITSGDVSIYFSMDEWDYI-EGHKELYKDLM-EKYQNYSAVEISDIQKSEIQDENTNNMCLTHSKE 167

Human    62 QGEQLWTIEDGIHSGACSDRVLLCAQAGAQWCELGSPQPPPPGFKRFLCLSPTPAPYLAHDIWKV 126
            ..|:...:|..|.|..|||.           |..|                      |..|:...
Frog   168 TEEENDLVEAEIESNICSDE-----------CTAG----------------------LVSDVEDT 199

Human   127 DHVLERLQSES--LVNRRKPCHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSK 189
            :....:.::||  ||.:..........|:   .|.|:.:|.. |....|..|.|: |:|
Frog   200 EQPSLKKENESPELVAQETTSTWQSILED---GSVSRNILSP-HSASRLSDKKLE-NIT------ 253

Human   190 GYEIKNSVEFTGNGDSFLHANHERLHTAIKFPASQKLISTK---SQFISPKHQKTRKLEKHHVCS 251
                ..|..|.|.            |.....||...:.:|:   |..||.:..||:..|..:|
Frog   254 ----STSPMFQGK------------HQEQNLPADSTICNTENCTSSSISYQCSKTKAQETGNV-- 300

Human   252 ECGKAFIKKSWLTD----------------HQVMHTGEKPHRCSLCEKAFSRKFMLTEHQRTHTG 300
            |.....:|....:|                |:....|||.|:|::|.|.|..|..||.|.|||||
Frog   301 EWNSIEVKLEMSSDSESSSQEQSCRNFQSLHEDETEGEKIHKCNVCGKQFGYKCYLTVHLRTHTG 365

Human   301 EKPYECPECGKAFLKKSRLNIHQKTHTGEKPYICSECGKGFIQKGNLIVHQRIHTGEKPYICNEC 365
            |||::|.||||....|::|.|||:||||||||.|.||||.|              ..|||
Frog   366 EKPHKCDECGKYIASKAKLIIHQRTHTGEKPYSCKECGKQF--------------RSKPY----- 411

Human   366 GKGFIQKTCLIAHQRFHTGKTPFVCSECGKSCSQKSGLIKHQRIHTGEKPFECSECGKAFSTKQK 430
                                                 |::|.|.||||||..|.:|||.|:.|.:
Frog   412 -------------------------------------LVEHMRSHTGEKPHRCDDCGKQFAYKSR 439

Human   431 LIVHQRTHTGERPYGCNECGKAFAYMSCLVKHKRIH 466
            ||||||||||.:|:.|.:|||.|.|:..|::|.:.|
Frog   440 LIVHQRTHTGLKPHRCYQCGKHFDYVCYLIRHLKTH 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF350	XP_016882583.1	None
LOC100487768	XP_031746881.1	KRAB_A-box	105..138	CDD:143639	14/34 (41%)
		COG5048	<218..460	CDD:227381	103/326 (32%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		zf-H2C2_2	355..376	CDD:404364	14/20 (70%)
		C2H2 Zn finger	371..391	CDD:275368	10/19 (53%)
		zf-H2C2_2	387..408	CDD:404364	16/34 (47%)
		C2H2 Zn finger	399..419	CDD:275368	12/75 (16%)
		zf-H2C2_2	411..436	CDD:404364	15/66 (23%)
		C2H2 Zn finger	427..447	CDD:275368	12/19 (63%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910