Protein Alignment TRPV4 and Trpv4

DIOPT Version :10

• Sequence 1: XP_011536932.2
• Gene: TRPV4 / 59341
• HGNCID: 18083
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_076460.1
• Gene: Trpv4 / 66026
• RGDID: 69337
• Length: 871
• Species: Rattus norvegicus
• Alignment Length: 871
• Identity: 826/871 - (94%)
• Similarity: 848/871 - (97%)
• Gaps: 0/871 - (0%)

Human    52 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGPGDGRP 116
            |||..:||||.||:|||.|||||||.|||||||||||||||||:||.|.||.|||||||||||||
  Rat     1 MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRP 65

Human   117 NLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDNKRWRKKIIEK 181
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||:|::||
  Rat    66 NLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEK 130

Human   182 QPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCL 246
            ||||||||||||||||||||||||||||||||||||||||.:|||||||||||||||||||||||
  Rat   131 QPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCL 195

Human   247 PKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQ 311
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 PKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQ 260

Human   312 GADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 376
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 GADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325

Human   377 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHII 441
            ||||||||||||||||||||||||||||:|||||||||.||||||||||||||||||||:|||||
  Rat   326 HALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHII 390

Human   442 RREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPI 506
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   391 RREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPI 455

Human   507 NELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFT 571
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
  Rat   456 NELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLLT 520

Human   572 GVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLG 636
            |||||||:||||||||||||||||:|||||||||||||||:||||||||||||||||||||||||
  Rat   521 GVLFFFTSIKDLFMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLG 585

Human   637 WMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQT 701
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||||.|||||||||:
  Rat   586 WMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQS 650

Human   702 NCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLI 766
            |||||:||:||||||||.||||||||||||||||||||.|||||||:||||||||||||||||||
  Rat   651 NCTVPSYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLI 715

Human   767 ALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV 831
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 ALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV 780

Human   832 DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPL 896
            |||||||||||||||||||||:|.|||||||||:||||||||||||||||||||||..|||||||
  Rat   781 DEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDEVVVPL 845

Human   897 DSMGNPRCDGHQQGYPRKWRTDDAPL 922
            |::|||.||||||||..|||.:||||
  Rat   846 DNLGNPNCDGHQQGYAPKWRAEDAPL 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPV4	XP_011536932.2	TRPV4	154..885	CDD:411979	705/730 (97%)
		ANK repeat	288..319	CDD:293786	30/30 (100%)
		ANK repeat	335..369	CDD:293786	33/33 (100%)
		ANK repeat	371..408	CDD:293786	35/36 (97%)
Trpv4	NP_076460.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		55/66 (83%)
		TRPV4	103..834	CDD:411979	705/730 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..143		28/32 (88%)
		ANK repeat	191..231	CDD:293786	39/39 (100%)
		ANK repeat	237..268	CDD:293786	30/30 (100%)
		ANK 1	237..266		28/28 (100%)
		ANK repeat	284..318	CDD:293786	33/33 (100%)
		ANK 2	284..313		28/28 (100%)
		ANK 3	369..398		27/28 (96%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:O35433	679..682		2/2 (100%)
		Interaction with calmodulin and ITPR3. /evidence=ECO:0000250|UniProtKB:Q9HBA0	812..831		17/18 (94%)