Protein Alignment TRPV4 and ocr-4

DIOPT Version :10

• Sequence 1: XP_011536932.2
• Gene: TRPV4 / 59341
• HGNCID: 18083
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_501172.2
• Gene: ocr-4 / 177506
• WormBaseID: WBGene00003841
• Length: 756
• Species: Caenorhabditis elegans
• Alignment Length: 823
• Identity: 193/823 - (23%)
• Similarity: 321/823 - (39%)
• Gaps: 215/823 - (26%)

Human   125 AFRKGVPNPIDLLESTLYESSVVPGP---KKAPMDSLFDYGTYRHHSSDNKRWRKKIIEKQPQSP 186
            |...|:.|.::...:.:.:.:.:.|.   ....||::   .|..|...|     |:|:||.
 Worm     7 AVTAGIKNQVNASNNAINKLADMSGRGFLADLAMDAV---RTGNHEELD-----KQILEKV---- 59

Human   187 KAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALL 251
                           :|:|:: ..:|....|..|:  ...||:| |...|..|.....|  :.:.
 Worm    60 ---------------QPMLYN-NGQGEMIPLSDLI--AQRHKER-TGNTFAVPVPSTEC--RFIC 103

Human   252 NLSNGRNDTIPVLLD-------------IAER-TGNMREFINSPFRDIYYRGQTALHIAIERRCK 302
            ...|.|......||.             :||| .....:.||..:....|.|:|.||:.|.....
 Worm   104 WKLNSRGAVGETLLHTCFLAGLPNHMKLLAERLIAIFPKIINDFYLSDEYYGETVLHMGIVSENA 168

Human   303 HYVELLVAQGADVHAQARGRFFQPKDE---------------------GGYFYFGELPLSLAACT 346
            .:|..|:..||||||:..|.||...|:                     .|:.|:||.|||.|||.
 Worm   169 EFVRYLLKSGADVHARCSGNFFTCDDQKGSRTDHPEVEHAIISKHTKYPGHIYWGEYPLSFAACL 233

Human   347 NQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS 411
            :||..:..|..:   .||:...|:.|||:|| :..|.:|        .:|:.:.|...|.|.
 Worm   234 SQPECIRMLVAH---GADVNAADTNGNTILH-ICTIHEN--------YEMFKMALSLGADLH--- 283

Human   412 NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLD 476
                :.|...|:||.:||...|..:.|.|:..|.|           .:|.||...|:.|.|..:|
 Worm   284 ----IQNRQNLTPLTLAAFLAKKEMMQRIVEEERT-----------VNWTYGRTQSAAYPLEHVD 333

Human   477 ----TCG--EEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINV----VSYLC 531
                |.|  .:.|||.|.||..|:|  |..|....:.:|:..||..:|..:.:..:    :.::|
 Worm   334 SIEPTSGSINQKSVLTIAVYGEKVE--HLSLLPHLLEQLVHHKWIAYGRKTLFAQLSMFCIYFIC 396

Human   532 AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLF------------TGVLFFFTNIKDLF 584
            ....|.|.          |.|:..   ...:|.::|..:            :.:::...::
 Worm   397 VTSCFLLR----------PSPFER---QQHIANDLICFYDFKTRRFNESAVSTIIYHLLHL---- 444

Human   585 MKKCPGVNSLFIDGSFQLLYFIYSVLVI--VSAALYLAGIEAY--LAVMVFALVL---------- 635
                     :.:.|:  .||.:.::|.|  |...||:.|:..:  .|:.:|:.:|
 Worm   445 ---------ICVTGA--TLYLVQALLHIKNVGYHLYVLGLSGFPAKAIFLFSCILMVITFFLRIF 498

Human   636 --------GW--------MNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALV 684
                    .|        :..|:|.||.|..|.:.:|:.||:.:||.||.|:||:.::|::.|..
 Worm   499 CLDEAEDIVWIVIVLLTSLKFLFFCRGFKSVGPFVLMLYKIIIRDLMRFFLIYLVIVVGFSQAFY 563

Human   685 SLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIIL 749
            .:.     :.....|..| ..|:..|.........|::.|.:.|:   ..|.|...::.|:..|.
 Worm   564 VIF-----LGYKRSDSGN-REPSIMSNVAESYVRMFIMSLTEFTV---FFEQLEECEHTVIGKIT 619

Human   750 LVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVT 814
            .|.|::|..:||:|||||:|..|..:||..|.. |..||:..||.:|:||....|..::
 Worm   620 FVVYMLLVTLLLINMLIAMMTNTYTEVSGNSLE-WLRQWSAIILMMEQSFDPATRLRYQ------ 677

Human   815 VGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNETYQ 857
                      ||:..|.|      ..:.|.::.:|....|.::
 Worm   678 ----------RRYGIRFD------GGEKLVLLLKDKMTEEEFE 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPV4	XP_011536932.2	TRPV4	154..885	CDD:411979	189/791 (24%)
		ANK repeat	288..319	CDD:293786	13/30 (43%)
		ANK repeat	335..369	CDD:293786	13/33 (39%)
		ANK repeat	371..408	CDD:293786	10/36 (28%)
ocr-4	NP_501172.2	TRPV	109..665	CDD:454755	156/625 (25%)
		ANK repeat	154..194	CDD:293786	16/39 (41%)
		ANK repeat	196..253	CDD:293786	15/59 (25%)
		ANK repeat	255..286	CDD:293786	11/46 (24%)