Protein Alignment RBL2 and Rbl2

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: XP_006255261.1
• Gene: Rbl2 / 81758
• RGDID: 3541
• Length: 1136
• Species: Rattus norvegicus
• Alignment Length: 1142
• Identity: 1027/1142 - (89%)
• Similarity: 1081/1142 - (94%)
• Gaps: 9/1142 - (0%)

Human     1 MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAE 65
            |.|||:||   .|||||||||.||||:||:..|.|.||.||:.||||||:|||||||||||||||
  Rat     1 MASGGNQS---SPPPPAAAASSEEEEEDGDTADRAQPAGSPSHQIQQRFEELCSRLNMDEAARAE 62

Human    66 AWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFN 130
            ||.||||||||||||||||||||||||||||||||||||||.|||||||||||:|||||||||||
  Rat    63 AWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFN 127

Human   131 KMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPC 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   128 KMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPC 192

Human   196 TVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSED 260
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat   193 TTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGVSED 257

Human   261 FHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPG 325
            .|.:||.|||||||:|||||||||||||||||||:||||||||||:|||||:|||||||||||||
  Rat   258 GHPRDSHPSSDPPCVIEKLCSLHDGLVLEAKGIKQHFWKPYIRKLFEKKLLRGKEENLTGFLEPG 322

Human   326 NFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQH 390
            ||.|||||:|||||||||:.|:||||||||||||||:||||||::|.||||:|||.||::|||||
  Rat   323 NFAESFKAVNKAYEEYVLATGSLDERIFLGEDAEEEVGTLSRCVSAASGTESAERTQMRDILQQH 387

Human   391 FDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDP 455
            .||||.||:..|||||||::||||||||||||||||:||||||.|||||||||||||||:|||||
  Rat   388 LDKSKTLRVCNPLTGVRYVQENSPCVTPVSTATHSLNRLHTMLAGLRNAPSEKLEQILRSCSRDP 452

Human   456 TQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLS 520
            |:|||:||:||:|||||||||||:.||||||:|:|||||||||||||||||||||||||||||||
  Rat   453 TRAIADRLREMYEIYSQHFQPDENVSNCAKEMANKHFRFAEMLYYKVLESVIEQEQKRLGDMDLS 517

Human   521 GILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKH 585
            |:|||||||:||||||||||.||||||||||||.||||||.||||||||||||||||||||||||
  Rat   518 GVLEQDAFHKSLLACCLEVVAFSYKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKH 582

Human   586 LNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVR 650
            |||||||||||||||.:||||::||||||||||||||.||.||||.|||.|||||||||||.|||
  Rat   583 LNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVTPPHNLERTDEIYIAGSPLTPRRVGEVR 647

Human   651 ADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGE 715
            .|.||||||:|||||||||||||..|||||||| |:||||:|.|.||:|||||||||||||||||
  Rat   648 TDAGGLGRSVTSPTTLYDRYSSPTVSTTRRRLF-ESDSPSEGSTAGRIPPQPLVNAVPVQNVSGE 711

Human   716 TVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPL 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   712 TVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPL 776

Human   781 SAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYH 845
            |||||||||||||||||||||||.|||||||||||||.|||.:||||.||||||||||||||||:
  Rat   777 SAQALAGSLSSQQVTGTTLQVPGPVAIQQISPGGQQQNQGQPLTSSSIRPRKTSSLSLFFRKVYY 841

Human   846 LAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQ 910
            ||.|||||||.||||||||||||||||||||:|||||||||||||||||||||||||||||||||
  Rat   842 LAGVRLRDLCTKLDISDELRKKIWTCFEFSIVQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQ 906

Human   911 NIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTL 975
            ||||||||||||||||||||||||  |||||||.::|||||||||||.||.||||||||||:|||
  Rat   907 NIMRCYRTQPQARSQVYRSVLIKG--KRRNSGSCENRSHQNSPTELNTDRASRDSSPVMRSNSTL 969

Human   976 PVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQAN---MDAPPLSPY 1037
            |||||||||||||||||||||:||||||||||||||||.|||:||||||||||   ||.||||||
  Rat   970 PVPQPSSAPPTPTRLTGANSDIEEEERGDLIQFYNNIYRKQIQTFAMKYSQANSQQMDTPPLSPY 1034

Human  1038 PFVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKR 1102
            ||||||||||:||||:||:||||||||.|||||||||||||||||||||||||||||||||||||
  Rat  1035 PFVRTGSPRRVQLSQSHPIYISPHKNEAMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKR 1099

Human  1103 GILLEDGSESPAKRICPENHSALLRRLQDVANDRGSH 1139
            ||||:||||||||||||||||||||||||||||||||
  Rat  1100 GILLDDGSESPAKRICPENHSALLRRLQDVANDRGSH 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		27/43 (63%)
		CYCLIN_SF	44..134	CDD:410207	85/89 (96%)
		DUF3452	104..239	CDD:463402	131/134 (98%)
		Pocket, binds E1A	417..1024		550/606 (91%)
		Domain A	417..616		178/198 (90%)
		RB_A	417..609	CDD:460364	172/191 (90%)
		Spacer	617..827		189/209 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		20/23 (87%)
		SP1-4_N	670..>810	CDD:425404	130/139 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		16/20 (80%)
		Domain B	828..1024		179/195 (92%)
		CYCLIN_RBL2	835..1024	CDD:410309	173/188 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		56/65 (86%)
Rbl2	XP_006255261.1	CYCLIN_SF	41..131	CDD:410207	85/89 (96%)
		DUF3452	101..236	CDD:463402	131/134 (98%)
		RB_A	414..606	CDD:460364	172/191 (90%)
		SP1-4_N	<696..>834	CDD:425404	132/137 (96%)
		CYCLIN_RBL2	831..1018	CDD:410309	173/188 (92%)