Protein Alignment RBL2 and Rbf

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_525036.2
• Gene: Rbf / 31027
• FlyBaseID: FBgn0015799
• Length: 845
• Species: Drosophila melanogaster
• Alignment Length: 1162
• Identity: 291/1162 - (25%)
• Similarity: 459/1162 - (39%)
• Gaps: 379/1162 - (32%)

Human     8 SPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRS 72
            |.|.|....|...|......|...|           .|...:..||..||||.....:.:::|..
  Fly     2 SEPDPQELGAEVVSGLVATSDDRLE-----------MINAEYTNLCRDLNMDRQTELQGYETYLE 55

Human    73 MSESYTLEGNDLHWLACALYVACRK-SVPTVS--KGTVEGNYVSLTRILKCSEQSLIEFFNKMKK 134
            :|:..::||...||:.||:|.|||: |.|||:  ...|:||.|||..:|:|.:.|:.||..|:|:
  Fly    56 VSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQ 120

Human   135 WEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQ----RGRKQRRQPC 195
            |.||||||..|....|.|:|.|:::.::.|::..|...||..|..|:...:    .|.....: |
  Fly   121 WCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCPPNEKKHSKYISLHGNHAHGK-C 184

Human   196 TVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSED 260
            :..::...||.||:.||...|..:.|||.||:|::|.:||:|.|.| ...|.:|:||.|:||..:
  Fly   185 SYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVL-AEKRTDLINPKFEGLPSN 248

Human   261 FHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPG 325
            :...|.:  .:|.||:...|.:.:    |||.:|...::..:...::...:.|.::.:.|.|...
  Fly   249 WTELDFR--HNPHCILSNFCDMTE----EAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANE 307

Human   326 NFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQH 390
            ||..:.|::|.:||:||||||..||||....||.|.     ..||
  Fly   308 NFERNLKSLNISYEQYVLSVGEFDERILSAYDAGEH-----TALN-------------------- 347

Human   391 FDKSKALRIS-TPLTGVRYIKENSPC--------VTPVSTATHSLSRLHTMLTGLRNAPSEKLEQ 446
               .::||.. ||||.    |::.|.        ..||..||:::.:|...  |....|::.::|
  Fly   348 ---DQSLRPPVTPLTR----KQDLPAQPAMAGDKFEPVRNATNNVKQLSAF--GRITEPTDFVKQ 403

Human   447 ILRTCSRDPTQAIANRLKEMFEIYSQHF---QPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIE 508
                    ..:.:..:|..:.|...|.|   .|..:        |...|:.|:..::.:|:.:::
  Fly   404 --------AGEEVIAKLLSIIEEIEQKFLAKYPSTE--------AKSRFQLAKSFFFYLLDQILQ 452

Human   509 QEQKRLGDMDLSGILEQDA----FHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIE 569
            .|.:...|:||..:|.|..    |:.:|:|||:|:|..:||....||::.:.|.:..:.|.|:||
  Fly   453 AEIRNKPDIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIE 517

Human   570 VFIR--AEDG-LCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERA 631
            :.:|  :.:| |.|.::||||.|||..|:.|||...|.:||.|...:..:||...|    ||:||
  Fly   518 IVVRHGSHEGCLNRSLIKHLNSIEETCLERLAWARNSTVWEMIASAQLPLPTWLMV----NLDRA 578

Human   632 DEICIAGSPLTPRRVTEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPG 696
                 ||
  Fly   579 -----AG---------------------------------------------------------- 580

Human   697 RMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFP 761
                                                                            |
  Fly   581 ----------------------------------------------------------------P 581

Human   762 VQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSS 826
            :|:
  Fly   582 LQI-------------------------------------------------------------- 584

Human   827 SNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQL 891
                        |.||||.|..:|::.||::|.:.::..:.||..||.||....|||.||||||.
  Fly   585 ------------FLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRHLDQN 637

Human   892 LMCAIYVMAKVTK-EDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTE 955
            :|||||:..:|.: ||..|.:|||.||.||||.:.|||.|.|                      :
  Fly   638 IMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFI----------------------D 680

Human   956 LNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTF 1020
            :|:     |..|.::                                 |:|.|||:.|:..::.|
  Fly   681 INE-----DGEPKVK---------------------------------DIIHFYNHTYVPLMRQF 707

Human  1021 AMKYSQANMDAP------PLSPYPFVRTGSPRRIQLSQNHPVYISP-HKNETMLSPREKIFYYFS 1078
            .:.|.....|..      .|||:|..|...|:::  :|:|.:::|. .|||...||.:.: |.|.
  Fly   708 VIDYLNVTPDVSGRASDLQLSPHPKERAAQPKKV--TQSHSLFVSQMSKNEIQQSPNQMV-YSFC 769

Human  1079 NSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENHSALLRRLQDVAND 1135
            .||:|.|:.:|..:|.|     ||  :|..|.| |......|...:.:.:::.|.:|
  Fly   770 RSPAKDLQAMNEKVRGG-----KR--MLSFGDE-PGLGTMAETKRSKISQVKAVMDD 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		7/36 (19%)
		CYCLIN_SF	44..134	CDD:410207	35/92 (38%)
		DUF3452	104..239	CDD:463402	50/138 (36%)
		Pocket, binds E1A	417..1024		127/617 (21%)
		Domain A	417..616		58/208 (28%)
		RB_A	417..609	CDD:460364	57/201 (28%)
		Spacer	617..827		11/209 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		0/23 (0%)
		SP1-4_N	670..>810	CDD:425404	2/139 (1%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		0/20 (0%)
		Domain B	828..1024		58/196 (30%)
		CYCLIN_RBL2	835..1024	CDD:410309	58/189 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		3/65 (5%)
Rbf	NP_525036.2	DUF3452	90..228	CDD:463402	50/138 (36%)
		RB_A	377..560	CDD:460364	57/200 (29%)
		RB_B	582..705	CDD:460363	58/256 (23%)