Protein Alignment RBL2 and Rbl2

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_035380.3
• Gene: Rbl2 / 19651
• MGIID: 105085
• Length: 1135
• Species: Mus musculus
• Alignment Length: 1140
• Identity: 1035/1140 - (90%)
• Similarity: 1081/1140 - (94%)
• Gaps: 8/1140 - (0%)

Human     1 MPSGGDQSPPPPPPPPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAE 65
            |.|||:||   ||||||||||.||||:||:|.|.|.||.||:.||||||:|||||||||||||||
Mouse     1 MASGGNQS---PPPPPAAAASSEEEEEDGDAADRAQPAGSPSHQIQQRFEELCSRLNMDEAARAE 62

Human    66 AWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFN 130
            ||.||||||||||||||||||||||||||||||||||||||.|||||||||||:|||||||||||
Mouse    63 AWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFN 127

Human   131 KMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPC 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   128 KMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPC 192

Human   196 TVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSED 260
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   193 TTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSED 257

Human   261 FHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPG 325
            .|.||||.||||||:||||||||||||||||||||||||||||||:|||||||||||||||||||
Mouse   258 CHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPG 322

Human   326 NFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQH 390
            ||||||||:|||||||||:.||||||:|||||||||:|||||||:|.||||:|||.||::|||||
Mouse   323 NFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTLSRCLSAASGTESAERTQMRDILQQH 387

Human   391 FDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDP 455
            .|||||||:.||||||||::||||||||||||.||||||||||:|||||||||||:|||:|||||
Mouse   388 LDKSKALRVCTPLTGVRYVQENSPCVTPVSTAAHSLSRLHTMLSGLRNAPSEKLERILRSCSRDP 452

Human   456 TQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLS 520
            |||||:|||||:|||||||||||:|||||||||:|||||||||||||||||||||||||||||||
Mouse   453 TQAIADRLKEMYEIYSQHFQPDENFSNCAKEIANKHFRFAEMLYYKVLESVIEQEQKRLGDMDLS 517

Human   521 GILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKH 585
            |:||.|||||||||||||||.||:|||||||||.||||||.||||||||||||||||||||||||
Mouse   518 GVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKH 582

Human   586 LNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVR 650
            |||||||||||||||.:||||::||||||||||||||||||||||.|||.|||||||||||.|||
Mouse   583 LNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERTDEIYIAGSPLTPRRVGEVR 647

Human   651 ADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGE 715
            ||.||||||||||||||||||||..|||||||| ||||||:|.|.||:||||||||||||||.||
Mouse   648 ADAGGLGRSITSPTTLYDRYSSPTVSTTRRRLF-ENDSPSEGSTSGRIPPQPLVNAVPVQNVPGE 711

Human   716 TVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPL 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
Mouse   712 TVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVAGSIQPL 776

Human   781 SAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYH 845
            |||||||||||||||||||||||.|||||||||||||..||.:||||.||||||||:|||||||:
Mouse   777 SAQALAGSLSSQQVTGTTLQVPGPVAIQQISPGGQQQNPGQPLTSSSIRPRKTSSLALFFRKVYY 841

Human   846 LAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQ 910
            ||.|||||||.|||||||||||||||||||||||.||||||||||||||||||||||||||:|||
Mouse   842 LAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKVTKEDRSFQ 906

Human   911 NIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTL 975
            ||||||||||||||||||||||||  ||||||||:||||||||||||.||.||||||||||:|||
Mouse   907 NIMRCYRTQPQARSQVYRSVLIKG--KRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTL 969

Human   976 PVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQAN--MDAPPLSPYP 1038
            ||||||||||||||||||:||:||||||||||||||||.|||:.|||||||||  .|.|||||||
Mouse   970 PVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIYRKQIQAFAMKYSQANAQTDTPPLSPYP 1034

Human  1039 FVRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRG 1103
            |||||||||:||||:||:|||||.||.|.||||||||||||||||||||||||||||||||||||
Mouse  1035 FVRTGSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRG 1099

Human  1104 ILLEDGSESPAKRICPENHSALLRRLQDVANDRGS 1138
            |||:|||||||||||||||||||||||||||||||
Mouse  1100 ILLDDGSESPAKRICPENHSALLRRLQDVANDRGS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		29/43 (67%)
		CYCLIN_SF	44..134	CDD:410207	85/89 (96%)
		DUF3452	104..239	CDD:463402	131/134 (98%)
		Pocket, binds E1A	417..1024		552/606 (91%)
		Domain A	417..616		180/198 (91%)
		RB_A	417..609	CDD:460364	174/191 (91%)
		Spacer	617..827		191/209 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		21/23 (91%)
		SP1-4_N	670..>810	CDD:425404	129/139 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		15/20 (75%)
		Domain B	828..1024		177/195 (91%)
		CYCLIN_RBL2	835..1024	CDD:410309	171/188 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		57/65 (88%)
Rbl2	NP_035380.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		30/44 (68%)
		CYCLIN_SF	41..131	CDD:410207	85/89 (96%)
		DUF3452	101..236	CDD:463402	131/134 (98%)
		Pocket, binds E1A	414..1021		555/609 (91%)
		Domain A	414..613		180/198 (91%)
		RB_A	414..606	CDD:460364	174/191 (91%)
		Spacer	614..824		192/210 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..698		30/37 (81%)
		SP1-4_N	<696..>831	CDD:425404	126/134 (94%)
		Domain B	825..1021		180/197 (91%)
		CYCLIN_RBL2	831..1018	CDD:410309	171/188 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..994		57/65 (88%)