Protein Alignment RBL2 and lin-35

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_491686.1
• Gene: lin-35 / 172249
• WormBaseID: WBGene00003020
• Length: 961
• Species: Caenorhabditis elegans
• Alignment Length: 1164
• Identity: 244/1164 - (20%)
• Similarity: 412/1164 - (35%)
• Gaps: 384/1164 - (32%)

Human    15 PPAAAASDEEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTL 79
            |||....|:.||||  |:.......:|.|  .|.|.|.|...|:.......||::|....:..:|
 Worm   103 PPALGEDDDYEEDD--ADSFIDKTNTPPP--SQSFLEGCRAANLPNDIVTGAWETYNHAVQRVSL 163

Human    80 EGNDLHWLACALYVACRKSVPTVSKG----------TVEGNYVSLTRILKCSEQSLIEFFNKMKK 134
            ||::..|...|:|..      .:|||          .::...||:..|....:.|:.|..:|..:
 Worm   164 EGSESAWQLSAIYYY------LLSKGIKRRGKTIRILIQPFPVSILTIANSFDISVAEMLDKTAR 222

Human   135 WEDMANLPP--HFRERTERLERNFTVSAVIFKKYEPIFQDIF---KYPQEEQPRQQRGRKQRRQP 194
            :.::.:...  .::|...|::....||.|||||:..||..||   |...|..|...
 Worm   223 FVEIIHSRKIRRYQEYIRRIQEGLAVSCVIFKKFCRIFCKIFEEIKVGSENCPSSH--------- 278

Human   195 CTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSE 259
                |:|...|..|:..|..  |..|||:::|.||...||.||..  .||.::.:|:...:...|
 Worm   279 ----ELFTVLWTSFLVMKSR--MTVDDLISNYQLLFSILDQVYTE--MCSMKEGIVHHLNQKFVE 335

Human   260 DFHAKDSKPSSDPPC-IIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLE 323
            |....|        | ||..||:...|.||:|:...:|.:         ||:.|      ||...
 Worm   336 DLLEND--------CTIIRALCTQFGGSVLDARHFSDHTF---------KKMEK------TGIPS 377

Human   324 PGNFGESFKAI-----NKAYEEYVLSVGNLDERIFLG--EDAEE--------EIGTLSRCLNAGS 373
            ..||.| |:.:     ..|||.|:|..|::|||||:.  ||..:        .:..:.:...:|.
 Worm   378 TWNFQE-FRDLIMNVPKTAYENYLLQRGSIDERIFIPSVEDFSKIFQSPDTYSVADILKVSYSGR 441

Human   374 GTETAE---RVQMKNILQQHFDKSKALRISTPLTGVRYIKENS-----PCV----------TPVS 420
            ....||   ::...:.|::       |.:...:...:.:.::.     |||          ..:.
 Worm   442 RFRDAEFLTKISNNHCLEK-------LALGGKVASEKLVTQSKEQPRVPCVEYNLELGNYPDDLE 499

Human   421 TATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEM---FE-------------- 468
            :...||....|.:.|.....:.|||::..|.|..|...|..:..||   ||
 Worm   500 SNNQSLYNRLTKIIGSWKLENSKLEEVCGTMSDSPMATILLKSDEMTNKFERTLSAELGETINEN 564

Human   469 IYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQE-QKRLGDMDLSGILEQDAFHRSL 532
            |...|:       |..||:        |:::...:|.:|..| :|::.:.||..::.::.|..|:
 Worm   565 IPKYHY-------NVRKEL--------ELVFLIFMEKIIVAELKKKVREEDLLNVIRREEFLDSV 614

Human   533 LACCLEVVTFS--YKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILD 595
            ...|:|::..|  |..|  ||:..|:..|..:.|:|||::.|..|..|.|::|:|.::|||.:::
 Worm   615 FCFCVELILVSNGYDRP--FPWSAELCGVHPFMFHKVIDLMITHEKQLSRQMVQHFSRIEETVIE 677

Human   596 HLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSI 660
            :.:||.:||||..:                                                  :
 Worm   678 YFSWKSDSPLWPMV--------------------------------------------------V 692

Human   661 TSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQ 725
            ..|...:..:....|..
 Worm   693 RCPFAHFQEFGEDWADK------------------------------------------------ 709

Human   726 TLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLS 790
                                     .|....|.|.|::
 Worm   710 -------------------------LNSYSPIKFTPIK--------------------------- 722

Human   791 SQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLC 855
                                .|...:.:.|:.:...:...|   :|.:|.::.|..||.||:||.
 Worm   723 --------------------KPDDLRDELGRPIVPQNQTSR---TLRIFLKRTYFTAARRLQDLT 764

Human   856 AKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQP 920
            .::.:....:.:.|:.|::.:.....:.|||||||:|:|.::|:.|:.:....|..||..||.|.
 Worm   765 DRVSMGARAKSQCWSLFDYLLRNDTLIFMDRHLDQILLCCVFVIMKINESSMLFTEIMAQYRRQS 829

Human   921 QARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPP 985
            .....|||||.:           ...:.:..:|..:|...|..:
 Worm   830 ANSLLVYRSVTV-----------FQEQLNPENPQAVNTKETILE--------------------- 862

Human   986 TPTRLTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQAN----MDAPPLSPYPFVRTGS-- 1044
               ||.|   ..:|:...|:|::||..:..:||....:...|:    |:.|       |.|.|
 Worm   863 ---RLEG---PQKEKTTVDIIKYYNIEFRDRIKYIIGQIDSASDEDLMEMP-------VATESGL 914

Human  1045 -PRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKR 1102
             |.|:.|:         ||......|:.|      :..||:.|.|.::.::|.|...:|
 Worm   915 MPVRVYLT---------HKLSIQTLPKTK------HGESKQERAIANLEKSGITIAMER 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		11/29 (38%)
		CYCLIN_SF	44..134	CDD:410207	23/99 (23%)
		DUF3452	104..239	CDD:463402	40/149 (27%)
		Pocket, binds E1A	417..1024		112/626 (18%)
		Domain A	417..616		57/218 (26%)
		RB_A	417..609	CDD:460364	57/211 (27%)
		Spacer	617..827		8/209 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		2/23 (9%)
		SP1-4_N	670..>810	CDD:425404	5/139 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		2/20 (10%)
		Domain B	828..1024		47/195 (24%)
		CYCLIN_RBL2	835..1024	CDD:410309	46/188 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		6/65 (9%)
lin-35	NP_491686.1	DUF3452	200..316	CDD:463402	37/130 (28%)
		PRK09248	<339..408	CDD:236429	26/92 (28%)
		RB_A	507..691	CDD:460364	55/200 (28%)
		RB_B	744..889	CDD:460363	44/182 (24%)