Protein Alignment RBL2 and rbl2

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: XP_002937369.2
• Gene: rbl2 / 100490373
• XenbaseID: XB-GENE-1012835
• Length: 1089
• Species: Xenopus tropicalis
• Alignment Length: 1122
• Identity: 747/1122 - (66%)
• Similarity: 904/1122 - (80%)
• Gaps: 40/1122 - (3%)

Human    23 EEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWL 87
            :|||::||.:.|       ..|::.|:|||||.|||||.||.|||:.|..:|::||||||.||||
 Frog     3 KEEEEEGEGKQA-------EEQLRCRYDELCSSLNMDERARGEAWEYYSRISQNYTLEGNALHWL 60

Human    88 ACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERL 152
            ||:||||||::||||.:|||||||||||:||..||.||||||||:||||||||||..||.||::|
 Frog    61 ACSLYVACRQTVPTVGRGTVEGNYVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRTKKL 125

Human   153 ERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPM 217
            |||||||||:||||:||||::|:.|.||||||.||||||||||||||::.|||||||:.||||||
 Frog   126 ERNFTVSAVLFKKYDPIFQEVFRSPLEEQPRQHRGRKQRRQPCTVSEVYQFCWVLFIHTKGNFPM 190

Human   218 ISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSL 282
            ||||||||||||||||||||||||||.||:||:||||:||.|||.:::.|...:.|||||.||.|
 Frog   191 ISDDLVNSYHLLLCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAPLEAPCIIETLCGL 255

Human   283 HDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGN 347
            |||||||||||||||||||||||::||:||||.::|.|||:||||.:|.||||||||.||||.||
 Frog   256 HDGLVLEAKGIKEHFWKPYIRKLFDKKILKGKSDSLVGFLDPGNFADSVKAINKAYEGYVLSAGN 320

Human   348 LDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIKEN 412
            ||||:|: ||.|||||.:.:|||...|.|:.||.::...|||:|||.|:||:|||||.::||:|.
 Frog   321 LDERVFM-EDVEEEIGRIGQCLNPSLGMESVERAKVTYNLQQNFDKFKSLRVSTPLTSLKYIREC 384

Human   413 SPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPD 477
            |||.||:|:|.:.:|||.|:|||.:.||||:|.|:||:||||||:.|..|||||.|.:.::....
 Frog   385 SPCTTPISSAMYCVSRLFTILTGFKPAPSERLLQMLRSCSRDPTKTILRRLKEMSETFCENTDSV 449

Human   478 EDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTF 542
            .:...| ::|..|:||.||:||||||||||:||:|||||:|:|.|||||.|||||::||||:..|
 Frog   450 AEKQFC-RDITKKYFRLAEVLYYKVLESVIDQEKKRLGDIDMSSILEQDVFHRSLMSCCLEITVF 513

Human   543 SYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWE 607
            |||||||||.|..:|::..|.|||||||.|:||:|||||||||||.||||||:.:||..:||||:
 Frog   514 SYKPPGNFPSIIVMFELAPYQFYKVIEVVIKAEEGLCREVVKHLNNIEEQILECMAWTHDSPLWD 578

Human   608 KIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRVTEVRADTGGLGRSI-TSPTTLYDRYS 671
            |||:|:.::|.||||:.||:.|::.:....|| |||||:.|:|||..|||||: :||.||.||||
 Frog   579 KIRENDGKIPLCEEVLHPQHFEKSGDNGTTGS-LTPRRINEIRADASGLGRSVPSSPATLCDRYS 642

Human   672 SPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVT 736
            ||.|.|.||||||:.||.|:.|:|.:..|           ::.:||:..||||||||||||||||
 Frog   643 SPAAGTARRRLFVDPDSSSEAGSPAQASP-----------LATDTVATPPVPGQTLVTMATATVT 696

Human   737 ANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQV 801
            ||||||||||||||||||||||||||||||..|..:||.|:.||:||||||.|:.|       |:
 Frog   697 ANNGQTVTIPVQGIANENGGITFFPVQVNVSSQPHSVTSSVPPLTAQALAGPLNPQ-------QI 754

Human   802 PGQVAIQQI--SPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDISDEL 864
            .|||::.|:  || |||.|  |::||   :.:|.|||:||.|:||.||::||:|||.||||||||
 Frog   755 QGQVSVSQVPASP-GQQSK--QNLTS---KLKKASSLTLFCRRVYCLASIRLKDLCLKLDISDEL 813

Human   865 RKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQVYRS 929
            |:|||||||||::.||||:.|||||||||||:||:.||||||.||.|||:|||.||.|.|.||||
 Frog   814 RRKIWTCFEFSLVHCPELIKDRHLDQLLMCAVYVITKVTKEDTSFHNIMKCYRVQPHASSHVYRS 878

Human   930 VLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGAN 994
            ||:| ||:||.|||||......||.|..||..||:.|||||||||||||||:||||||||:|.|.
 Frog   879 VLLK-KRRRRQSGSSDHILQPGSPAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAG 942

Human   995 SDMEEEERGDLIQFYNNIYIKQIKTFAMKYSQAN-MDAPPLSPYPFVRTGSPRRIQLSQNHPVYI 1058
            |:..|||||||:||||||||::||:|||::||:| .:|.||||||.:|..||||||||..|.:|:
 Frog   943 SNFVEEERGDLVQFYNNIYIEKIKSFAMRFSQSNTSEATPLSPYPSIRAVSPRRIQLSHIHSIYV 1007

Human  1059 SPHKNE-TMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPAKRICPENH 1122
            |.|.:: |.:.|||||.|||..||:|||:||||||||||||||||||||||||||||||||.|||
 Frog  1008 STHNDDATTVCPREKICYYFDLSPAKRLQEINSMIRTGETPTKKRGILLEDGSESPAKRICQENH 1072

Human  1123 SALLRRLQDVANDRGSH 1139
            |||:|||||||||||:|
 Frog  1073 SALIRRLQDVANDRGTH 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		6/21 (29%)
		CYCLIN_SF	44..134	CDD:410207	64/89 (72%)
		DUF3452	104..239	CDD:463402	110/134 (82%)
		Pocket, binds E1A	417..1024		384/609 (63%)
		Domain A	417..616		122/198 (62%)
		RB_A	417..609	CDD:460364	118/191 (62%)
		Spacer	617..827		124/212 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		16/24 (67%)
		SP1-4_N	670..>810	CDD:425404	84/139 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		9/22 (41%)
		Domain B	828..1024		138/195 (71%)
		CYCLIN_RBL2	835..1024	CDD:410309	136/188 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		43/65 (66%)
rbl2	XP_002937369.2	CYCLIN_SF	23..107	CDD:410207	62/83 (75%)
		DUF3452	78..212	CDD:463402	110/133 (83%)
		RB_A	389..580	CDD:460364	118/191 (62%)
		SP1-4_N	<606..>787	CDD:425404	120/205 (59%)
		CYCLIN_RBL2	784..972	CDD:410309	136/188 (72%)