Protein Alignment RBL2 and rbl2

DIOPT Version :10

• Sequence 1: NP_005602.3
• Gene: RBL2 / 5934
• HGNCID: 9894
• Length: 1139
• Species: Homo sapiens
• Sequence 2: XP_002667000.4
• Gene: rbl2 / 100331892
• ZFINID: ZDB-GENE-061109-2
• Length: 1079
• Species: Danio rerio
• Alignment Length: 1129
• Identity: 698/1129 - (61%)
• Similarity: 858/1129 - (75%)
• Gaps: 67/1129 - (5%)

Human    23 EEEEDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWL 87
            |||:..|:.:.|              |:|||..|||||.:...||.||.::|::|||||::||||
Zfish     3 EEEDTLGKTKHA--------------FEELCRDLNMDEESSNRAWRSYENISKNYTLEGSELHWL 53

Human    88 ACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERL 152
            ||:||||||.||||:||||.|||||||||||:.|:|||||||:|||||:||||||..|::.||:|
Zfish    54 ACSLYVACRSSVPTMSKGTAEGNYVSLTRILRSSQQSLIEFFSKMKKWQDMANLPRDFQQSTEKL 118

Human   153 ERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPM 217
            ||||||::||||||.|:|:||||.|.:|.||..|||||||.||||:|:|:|||:|||:|||||||
Zfish   119 ERNFTVTSVIFKKYLPLFRDIFKTPTDELPRTHRGRKQRRHPCTVTEVFNFCWILFIHAKGNFPM 183

Human   218 ISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSL 282
            ||||||||||||||||||||.|||.||:||:|:||.||||.|||::||.||.....|.||:||.|
Zfish   184 ISDDLVNSYHLLLCALDLVYCNALLCSSRKDLLNPAFKGLPEDFNSKDYKPGPGSLCFIEQLCEL 248

Human   283 HDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGN 347
            ||||||||||.|||||||:|:||:|:|:|||||:.|||||||.|||:|..::|:.|||:|||.|:
Zfish   249 HDGLVLEAKGAKEHFWKPFIKKLFERKILKGKEDTLTGFLEPVNFGDSLASLNRVYEEHVLSSGS 313

Human   348 LDERIFLGEDAEEEIGTLSRCLNAG--SGTETAERVQMKNILQQHFDKSKALRISTPLTGVRYIK 410
            ||||||||:.|.|:|||      .|  .|.|..:|.  .|.||.....| |||:||||||.||:.
Zfish   314 LDERIFLGDGAREDIGT------PGPYEGIENQDRA--NNPLQNSMTAS-ALRVSTPLTGRRYVP 369

Human   411 ENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQ 475
            | |...||||:|..|:.||||:|||.:..||.||..|.|:|.||||:::|.|||||.||:.|:::
Zfish   370 E-SIVGTPVSSAMQSVGRLHTLLTGFKYRPSVKLRDIFRSCIRDPTESVAARLKEMSEIFLQNYE 433

Human   476 -PDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEV 539
             ..:|..:.|::||.|:|..||.||||.||.:|.||:|||||:||||:||||.|||||:|||||:
Zfish   434 GTGDDNKSLARDIAVKYFCLAEALYYKSLEVIINQEKKRLGDVDLSGVLEQDVFHRSLIACCLEI 498

Human   540 VTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESP 604
            |.|||:|||.||.:.:|||:|.|||||||||.:|||:.|.||||||||.:|||:|:.||||..||
Zfish   499 VIFSYRPPGEFPRVLQIFDLPAYHFYKVIEVLVRAEESLFREVVKHLNHVEEQVLESLAWKGNSP 563

Human   605 LWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPL-TPRRVTEVRAD-TGGLGRSIT-SPTTL 666
            |||:||:.:|.||.|:||||||:||..     :||.. ||...||...: ..|.|:.:: |||:|
Zfish   564 LWERIREAKNCVPACQEVMPPQHLEDG-----SGSNANTPSSKTEFSGNIAAGAGKGVSPSPTSL 623

Human   667 YDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMA 731
            :|||||||..|..|||||:.|:..:...|.::.|..:|:::|.              |||:||||
Zfish   624 HDRYSSPPTGTAVRRLFVDGDTTPEPAPPVKVAPPSIVSSIPA--------------GQTVVTMA 674

Human   732 TATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTG 796
            ||||||||||||||||||||||:|||||.||||:|..||.|   ::..||||.|.|:|::||:|.
Zfish   675 TATVTANNGQTVTIPVQGIANESGGITFIPVQVSVTSQAGA---TLPTLSAQTLTGTLTTQQLTT 736

Human   797 TTLQVPGQVAIQ-QISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFRKVYHLAAVRLRDLCAKLDI 860
            |.:.     |:| ..||..|.:|..|..| .:.|.:||.||.||||||||||:||||||||||||
Zfish   737 TPMG-----AVQNNPSPPKQDKKTPQQGT-PTKRAQKTGSLCLFFRKVYHLASVRLRDLCAKLDI 795

Human   861 SDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRTQPQARSQ 925
            |.:||:|||||||:|::.|.:||||||||||||||||||.|||||||||||||:|||:||||.|.
Zfish   796 SADLRRKIWTCFEYSLVHCTDLMMDRHLDQLLMCAIYVMTKVTKEDKSFQNIMKCYRSQPQASSS 860

Human   926 VYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPV-MRSSSTLPVPQPSSAPPTPTR 989
            |||||||.| ||||:||::::...|:||||..:::.|.:|||| ||||||||:|||||||.||||
Zfish   861 VYRSVLISG-RKRRHSGNTENTHRQSSPTEGAQEQASGESSPVSMRSSSTLPIPQPSSAPSTPTR 924

Human   990 LTGANSDMEEEERGDLIQFYNNIYIKQIKTFAMKYS-----QANMDAPPLSPYPFVRTGSPRRIQ 1049
            ..|...: :||||||||:|||::||||||.||::||     ....:.|||.|||.:|.|||||:.
Zfish   925 APGGPQE-QEEERGDLIRFYNHVYIKQIKPFALRYSSNSPKNGQAETPPLCPYPSLRIGSPRRVL 988

Human  1050 LSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLREINSMIRTGETPTKKRGILLEDGSESPA 1114
            ||.||.:||||||..:.:|||:|||||.|:|||.||||||:||||||||||||.|.||:..:|||
Zfish   989 LSHNHSIYISPHKTGSPISPRDKIFYYVSSSPSHRLREINTMIRTGETPTKKRSIALEEEQQSPA 1053

Human  1115 KRICPENHSALLRRLQDVANDRGS 1138
            ||:|.||.:|||||||||||||.|
Zfish  1054 KRLCQENQTALLRRLQDVANDRSS 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBL2	NP_005602.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		5/21 (24%)
		CYCLIN_SF	44..134	CDD:410207	60/89 (67%)
		DUF3452	104..239	CDD:463402	105/134 (78%)
		Pocket, binds E1A	417..1024		366/612 (60%)
		Domain A	417..616		123/199 (62%)
		RB_A	417..609	CDD:460364	120/192 (63%)
		Spacer	617..827		101/213 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..678		13/24 (54%)
		SP1-4_N	670..>810	CDD:425404	71/140 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..831		7/20 (35%)
		Domain B	828..1024		141/196 (72%)
		CYCLIN_RBL2	835..1024	CDD:410309	138/189 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..999		37/66 (56%)
rbl2	XP_002667000.4	None