Protein Alignment PLEKHA1 and plekha1b

DIOPT Version :9

• Sequence 1: XP_011538319.1
• Gene: PLEKHA1 / 59338
• HGNCID: 14335
• Length: 416
• Species: Homo sapiens
• Sequence 2: XP_005156159.1
• Gene: plekha1b / 100537419
• ZFINID: ZDB-GENE-110408-54
• Length: 401
• Species: Danio rerio
• Alignment Length: 369
• Identity: 228/369 - (61%)
• Similarity: 269/369 - (72%)
• Gaps: 32/369 - (8%)

Human     1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYIS 65
            ||||||||||||||||||.|||||||||||||||.:.|.:|:||||||||.|:|.||:|||||||
Zfish     1 MPYVDRQNRICGFLDIEEMENSGKFLRRYFILDTMDSSLMWFMDNPQNLPEGTSNVGSIKLTYIS 65

Human    66 KVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDS-QPNS---- 125
            |||||||||||||||||:||||||::|||||:|||||||:.||||.||||||..:. .||:
Zfish    66 KVSDATKLRPKAEFCFVINAGMRKFYLQANDKQDLVEWVSELNKATKITVPKSGEQVAPNTAEAC 130

Human   126 -DNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQD 189
             |..|    ...|||||:|:||.||||||.||  |..|.....|::.|::....|||:..:..||
Zfish   131 VDTSS----SATKQVSYKTEIVAGVPIITTTQ--EKGEGQNGADKSGLRKPPGQLPYYLSRSNQD 189

Human   190 SAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMR 254
            .:|||.||||||||||||||||||.||:|.:.|||:::|:|||:||.||||:|||||||||:|||
Zfish   190 QSVIKTGYCVKQGAVMKNWKRRYFMLDDNALSYFKTDMEREPLKVILLKEVNKVQECKQSDLMMR 254

Human   255 DNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSQ----------SSMRLSAK 309
            |||||:|||:||||:|:|||||||.||||:||||||||||||||:|:          ....|...
Zfish   255 DNLFELVTTTRTFYIQSDSPEEMHGWIKAISGAIVAQRGPGRSAASEPAEPTSTFYHDEPSLPTS 319

Human   310 TVSVGKRKSWRRICGRPEGCRTLVYRGIHQELVNAARASPRSFR 353
            ...|....|:.. |..|.|         ||..|..:||:..:.|
Zfish   320 RSPVPAELSFPE-CHLPSG---------HQHGVGGSRANQHAGR 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHA1	XP_011538319.1	PH1_TAPP1_2	1..117	CDD:270089	97/115 (84%)
		PH2_TAPP1_2	185..298	CDD:270090	87/112 (78%)
plekha1b	XP_005156159.1	PH-like	1..118	CDD:302622	98/116 (84%)
		PH	10..112	CDD:278594	84/101 (83%)
		PH2_TAPP1_2	185..298	CDD:270090	87/112 (78%)
		PH	192..288	CDD:278594	75/95 (79%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344612
Domainoid	1	1.000	178	1.000	Domainoid score	I14664
eggNOG	1	0.900	-	-		E1_28KM6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44999
OrthoDB	1	1.010	-	-		D1513983at2759
OrthoFinder	1	1.000	-	-		FOG0009025
OrthoInspector	1	1.000	-	-		otm28072
orthoMCL	1	0.900	-	-		OOG6_110240
Panther	1	1.100	-	-	LDO	PTHR14336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6760
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.260