Protein Alignment PRDM13 and sem-4

DIOPT Version :10

• Sequence 1: NP_067633.2
• Gene: PRDM13 / 59336
• HGNCID: 13998
• Length: 707
• Species: Homo sapiens
• Sequence 2: NP_491997.1
• Gene: sem-4 / 172435
• WormBaseID: WBGene00004773
• Length: 744
• Species: Caenorhabditis elegans
• Alignment Length: 753
• Identity: 148/753 - (19%)
• Similarity: 218/753 - (28%)
• Gaps: 307/753 - (40%)

Human   114 SLAQWFDIPTTAT----PTHDEKGEERYICWYCWRTFRYPNSLKAHLRFHCVFSGGGGGAFLHHE 174
            |.:|.|..|...|    ..|::: :|.:.|..|..||.....::.|   .|           ...
 Worm   105 SCSQSFSSPAALTWHVLDAHEDE-QEIFSCDVCTTTFSNGQDIREH---KC-----------QKT 154

Human   175 HAARQGAVP----AADGLGLS-PKPPAPDFAAPSQAGTLRPHPLGPPPVQACGAREGIKREASSA 234
            .|:|..:||    .:....|| |..|...|:.....||
 Worm   155 LASRSTSVPPSTIPSSVCFLSTPTTPCLQFSINESIGT--------------------------- 192

Human   235 PSATSPTPGKWGQPKKGKEQLDRALDMSGAARGQ--GHFLGIVGGSS--AGVGSLAFYPG----- 290
                       .:.::..|:.|..::.......|  ||.|......|  |.:.:.||.|.
 Worm   193 -----------SEIREEDEEEDMDVEDGEHVANQLFGHLLQKSDDKSKMASLFNHAFPPFAAFPN 246

Human   291 ------VRSAFKPAGLARA---AAAAHG-----DPYREESSSKQGAGLALGRLLGGGRA------ 335
                  :|..|.|    ||   ||..|.     :...|.|:|.:...:   |.|.|.:|
 Worm   247 MPPPFLMRQPFDP----RADVFAAGRHDNDDDWEALMEISTSDEAEKI---RALVGDKAVPTTDP 304

Human   336 -----CGRPGSGENSAAGGAGHHHHHHAHHHHHP-KCLLAGDPPPPPPPGLPCSGA--------- 385
                 |.|..|.:::.      ..|:..|....| ||.:             |..|
 Worm   305 NQCILCRRVLSCKSAL------QMHYRTHTGERPFKCKI-------------CQRAFTTKGNLKT 350

Human   386 ----------LRGFPLLSVPPEEASAFKHVERA----------PPAAAALPGARYAQLPPAPGLP 430
                      .||.| :|:||:.|:..:|..:.          ||.:||...|..||:..:...|
 Worm   351 HMGVHRSKHSFRGLP-ISLPPQLAAMHQHQHQIAPPQRIHIHNPPTSAASAAAAVAQIQASQQCP 414

Human   431 LERCALPPLDPGGLKAYPGGECSHL---PAVMPAFTVYNGELLYGSPATT-----AYYPL----- 482
            :  |....|:.|.|..:.....:.|   |.|||            :|.||     .:.|.
 Worm   415 I--CQQRFLNAGELAVHITEHRNSLTQPPRVMP------------TPTTTRVQTFPFVPFFTTPP 465

Human   483 ---------KLHFGGLL---------------KYPESISYFSGPAAAALSPAELGSLASIDREIA 523
                     :.:...:|               ...|.|:....|..|:|||:.....:|..|:..
 Worm   466 SLNATDMSTQFNLANILSAQLKNDSSPNTDTSSVEEKITRDDPPKMASLSPSNSSDSSSSVRQDI 530

Human   524 MHNQQLSEMAAGKGRGRLDSGTLPPAVAAAGGTGGGGSGGSGAGKPK------------------ 570
            :.:.:..|        :|.....||.:.....|         ...||
 Worm   531 LESSEFEE--------KLKKLEEPPILEQQVST---------TPNPKNENPLLAMQKMWAETEPP 578

Human   571 --------TGHLCLYCGKLYSRKYGLKIHMRTHTGYKPLKCKVCLRPFGDPSNLNKHIRLHAEGN 627
                    :.|.|..|.|.:|....|:||||||||.||.||.:|.|.|....||..|:..|:...
 Worm   579 PPRQMPVLSKHQCGVCFKHFSSSSALQIHMRTHTGDKPFKCDMCGRAFTTRGNLKVHMGTHSWQQ 643

Human   628 TPYR-------------------------------------------------------CEFCGK 637
            :|.|                                                       |..|.|
 Worm   644 SPSRRGRRIFDVASSVTEKPMLQSPILPTSGAPGASPLAMLGPNGLSGLEMMMMLWRTVCSVCQK 708

Human   638 VLVRRRDLERHVKSR-HPGQSLLAKAGDGPGAEPGYPP 674
            |.....:||:|:|.. :.|.|    |...|.|....||
 Worm   709 VCQSPNELEQHLKEHLNNGSS----AAPTPLASAATPP 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRDM13	NP_067633.2	PR-SET_PRDM13	18..119	CDD:380974	2/4 (50%)
		C2H2 Zn finger	137..160	CDD:275369	5/22 (23%)
		zf-C2H2	137..159	CDD:395048	5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..213		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..255		1/28 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..372		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..567		3/21 (14%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		zf-C2H2	575..595	CDD:395048	9/19 (47%)
		SFP1	<578..653	CDD:227516	33/130 (25%)
		C2H2 Zn finger	603..623	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..650	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..707		9/29 (31%)
sem-4	NP_491997.1	C2H2 Zn finger	307..327	CDD:275368	4/25 (16%)
		zf-H2C2_2	319..344	CDD:463886	7/43 (16%)
		C2H2 Zn finger	335..355	CDD:275368	3/32 (9%)
		lambda-1	553..>610	CDD:212564	12/65 (18%)
		zf-C2H2	589..611	CDD:395048	10/21 (48%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		zf-H2C2_2	603..628	CDD:463886	16/24 (67%)
		C2H2 Zn finger	619..639	CDD:275368	7/19 (37%)