DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik1 and par-1

DIOPT Version :9

Sequence 1:NP_067725.2 Gene:Sik1 / 59329 RGDID:69407 Length:776 Species:Rattus norvegicus
Sequence 2:NP_995894.2 Gene:par-1 / 2768852 FlyBaseID:FBgn0260934 Length:1170 Species:Drosophila melanogaster


Alignment Length:828 Identity:268/828 - (32%)
Similarity:384/828 - (46%) Gaps:209/828 - (25%)


- Green bases have known domain annotations that are detailed below.


  Rat     3 IMSEFSAVP------TGTGQG-------QQKPLR-------VGFYDVERTLGKGNFAVVKLARHR 47
            ::|..||.|      |.:.:|       ...|:|       :|.|.:.:|:||||||.||||:|.
  Fly   209 VLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHL 273

  Rat    48 VTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMF 112
            .|..:|||||||||:|:..:|:|::|||::||:|:||||:||:||:||:..||::.|:|..||:|
  Fly   274 PTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVF 338

  Rat   113 DYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPG 177
            |||..:|.:.|.|||.||.||:|||:|||...|:|||||.||||||..::||:|||||.|.:.||
  Fly   339 DYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPG 403

  Rat   178 EPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFR 242
            ..|.|:||||||||||:|:||:|:||::|:|||||:||.||.|||||||..|..||:|||.|::|
  Fly   404 SKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYR 468

  Rat   243 IPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFSMQGYTSNLGDY-NE 306
            |||:||.|||.|:|:.||::||||.::..|...:||...   .::|:    ::.|.....|. :.
  Fly   469 IPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG---FEEDE----LKPYIEPKADLADP 526

  Rat   307 QVLGIMQALGIDRQRTVESLQNSSYNHFAAIYYLLLERLREHRSTQPSSRATPAPARQPQLRNSD 371
            :.:..:.|:|.:|.....||....|:...|. ||||.|    :||.|.|..:.: .....|||  
  Fly   527 KRIEALVAMGYNRSEIEASLSQVRYDDVFAT-YLLLGR----KSTDPESDGSRS-GSSLSLRN-- 583

  Rat   372 LSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLFFPLDTNCSGVFRHRSI 436
            :|..:.                      ..:...|.:....|..:                ||||
  Fly   584 ISGNDA----------------------GANAGSASVQSPTHRGV----------------HRSI 610

  Rat   437 SPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPP-CIIVSSSAAVS 500
            |.||   |..|..|..|             .|.|....|:|..:.....:||. ....:.|||..
  Fly   611 SASS---TKPSRRASSG-------------VGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADR 659

  Rat   501 PSEGT------SSDSCLPFSASEGPAGLGG-----GLATPGLLGTSSPVRLASPFLGSQSAT--- 551
            .|.|:      :.||.   :..|..|.|..     ..||..:| |::...|.|| ...::||   
  Fly   660 ASVGSNFKRQNTIDSA---TIKENTARLAAQNQRPASATQKML-TTADTTLNSP-AKPRTATKYD 719

  Rat   552 PVLQSQAGLGAT-VLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVC 615
            |...::...|.: ::|..|.....:.|.|..|..:.         |.|..|         .|...
  Fly   720 PTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIP---------AETNLF---------DRLRM 766

  Rat   616 QSSIRGSR------GGMSTFH---------TPAPSSGLQGCTA-SSREGRSLLEEVLHQQRLLQL 664
            .|:::.||      ...||||         |....||..|.:. ||..||              :
  Fly   767 ASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGR--------------M 817

  Rat   665 QHHSAVSSDYQQAPQL---SPVPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHLHI 726
            ...|.:||.:.:.|.:   :..|.||.....:..:. ||:|..::|       ...::||     
  Fly   818 SFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTS-PLMPDQIMQ-------KIREVLD----- 869

  Rat   727 SAGPVALPTGPLPQCLTRLSPSCDPAGLPQGDCEMEDLTSGQRGTFVL 774
                                         |.:|:.|     ||..|||
  Fly   870 -----------------------------QNNCDYE-----QRERFVL 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik1NP_067725.2 STKc_SIK 26..278 CDD:270973 149/251 (59%)
UBA_SIK1 300..349 CDD:270591 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..371 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..472 4/22 (18%)
RK-rich region. /evidence=ECO:0000250 586..612 3/25 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..643 10/36 (28%)
par-1NP_995894.2 STKc_MARK 252..504 CDD:270974 149/251 (59%)
S_TKc 253..504 CDD:214567 149/250 (60%)
UBA_MARK_Par1 525..563 CDD:270522 11/38 (29%)
MARK1-3_C 839..936 CDD:213381 17/92 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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