Protein Alignment RBBP7 and mis16

DIOPT Version :10

• Sequence 1: XP_047298247.1
• Gene: RBBP7 / 5931
• HGNCID: 9890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_587881.1
• Gene: mis16 / 2539214
• PomBaseID: SPCC1672.10
• Length: 430
• Species: Schizosaccharomyces pombe
• Alignment Length: 466
• Identity: 207/466 - (44%)
• Similarity: 278/466 - (59%)
• Gaps: 70/466 - (15%)

Human    57 ERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTS-DEQN 120
            ::.|.||||:||:|.|||||||:||||:|||||:||||:.....|.||::..|:|||||| ::||
pombe    23 QKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTSGNDQN 87

Human   121 HLVVARVHIPNDDAQFDASHCDSDKGEF--------GGFGSVTGKIECEIKINHEGEVNRARYMP 177
            :|.:|.|.:||         .|.|..||        ...||.|  ||...||.|:|:||||||||
pombe    88 YLQIASVQLPN---------FDEDTTEFTPSTIRRAQATGSYT--IEISQKIPHDGDVNRARYMP 141

Human   178 QNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDD 242
            |.|.||||.....:..:||.|.|.|.  .:||..|...|:||..||:||.||.||.|:|.:.::|
pombe   142 QKPEIIATMGEGGNAYIFDTTCHDAL--TTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAED 204

Human   243 HTVCLWDINA---GPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNT 304
            ..:||||:..   ...|.|::...|.:..|:.:|.||.:|..||:|..||:||..|.|.|||.|.
pombe   205 QVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNP 269

Human   305 TSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVCDS 369
            ..:...::.||:..:|.::.||:::::|||.|||||||||||||...:|||.|.|:||::
pombe   270 EEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVY----- 329

Human   370 FLVSVCQEMKSRDSSVKLYQTRGSTIEKNVLYVVLHGDAHRVHWSPHNETILASSGTDRRLNVWD 434
                                                    .:.||||:|.|||||.||||:.:||
pombe   330 ----------------------------------------GLEWSPHDEPILASSSTDRRVCIWD 354

Human   435 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYND 499
            |.||||||:.||||||.|||||:|||||.:||:|||.|||.||:.|:::|||:|||..:..|:..
pombe   355 LEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGR 419

Human   500 EESDVTTSELE 510
            :...|:..:||
pombe   420 DHVQVSPRDLE 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBBP7	XP_047298247.1	CAF1C_H4-bd	62..131	CDD:463513	42/69 (61%)
		WD40	166..491	CDD:475233	146/327 (45%)
		WD40 repeat	171..218	CDD:293791	22/46 (48%)
		WD40 repeat	223..267	CDD:293791	17/46 (37%)
		WD40 repeat	274..308	CDD:293791	16/33 (48%)
		WD40 repeat	319..357	CDD:293791	22/37 (59%)
		WD40 repeat	371..459	CDD:293791	34/87 (39%)
		WD40 repeat	465..490	CDD:293791	15/24 (63%)
mis16	NP_587881.1	CAF1C_H4-bd	28..98	CDD:463513	42/69 (61%)
		WD40	<130..413	CDD:441893	147/329 (45%)
		WD40 repeat	135..180	CDD:293791	22/46 (48%)
		WD40 repeat	185..224	CDD:293791	15/38 (39%)
		WD40 repeat	239..278	CDD:293791	16/38 (42%)
		WD40 repeat	284..322	CDD:293791	22/37 (59%)
		WD40 repeat	328..379	CDD:293791	34/95 (36%)
		WD40 repeat	385..410	CDD:293791	15/24 (63%)