Protein Alignment RBBP7 and lin-53

DIOPT Version :10

• Sequence 1: XP_047298247.1
• Gene: RBBP7 / 5931
• HGNCID: 9890
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_492552.1
• Gene: lin-53 / 172802
• WormBaseID: WBGene00003036
• Length: 417
• Species: Caenorhabditis elegans
• Alignment Length: 466
• Identity: 294/466 - (63%)
• Similarity: 353/466 - (75%)
• Gaps: 50/466 - (10%)

Human    47 LRTVFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVL 111
            :.|:.:.|.|:||.|:|||||||||||||||||||||:||||:|||||:|.| :..|:.:|.|:|
 Worm     1 MATLEDGTSEDRVANDEYKIWKKNTPFLYDLVMTHALEWPSLSVQWLPDVAK-DNSDHTIHRLIL 64

Human   112 GTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYM 176
            |||||||||||:::::.:|.||||||||..|:::.|:||||:|.||:|.:|:|||||||||||||
 Worm    65 GTHTSDEQNHLLISKICMPTDDAQFDASRYDTERSEYGGFGAVNGKVEPDIRINHEGEVNRARYM 129

Human   177 PQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASD 241
            ||..:|||||:|.:||.:|||.||.|.| .....||.:||:||.|||||||||.|..|.:|||||
 Worm   130 PQKSNIIATKSPHADVYIFDYLKHSAVP-RDNTFNPLIRLKGHTKEGYGLSWNPNKEGLILSASD 193

Human   242 DHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTS 306
            |.|||.|||||.......:.||.:|.||.:||||||||:||:.:||||.||:||:|||.|   ||
 Worm   194 DQTVCHWDINANQNVAGELQAKDVFKGHESVVEDVAWHVLHDGVFGSVGDDKKLLIWDVR---TS 255

Human   307 KPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVCDSFL 371
            .|.|.:|||:||||||:||||||||||||||||||||||||||::|||:||||:|||||
 Worm   256 TPGHCIDAHSAEVNCLAFNPYSEFILATGSADKTVALWDLRNLRMKLHSFESHRDEIFQ------ 314

Human   372 VSVCQEMKSRDSSVKLYQTRGSTIEKNVLYVVLHGDAHRVHWSPHNETILASSGTDRRLNVWDLS 436
                                                   |.|||||||||||||||:||:|||||
 Worm   315 ---------------------------------------VQWSPHNETILASSGTDKRLHVWDLS 340

Human   437 KIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEE 501
            ||||:||||||||||||||||||||||||||||||||||||:||||||||:|:||||:||||:.:
 Worm   341 KIGEDQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVVCSVSEDNILQVWQMADNIYNEVD 405

Human   502 SDVTTSELEGQ 512
            .:.....:|.|
 Worm   406 EETPADVVERQ 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RBBP7	XP_047298247.1	CAF1C_H4-bd	62..131	CDD:463513	47/68 (69%)
		WD40	166..491	CDD:475233	209/324 (65%)
		WD40 repeat	171..218	CDD:293791	27/46 (59%)
		WD40 repeat	223..267	CDD:293791	25/43 (58%)
		WD40 repeat	274..308	CDD:293791	22/33 (67%)
		WD40 repeat	319..357	CDD:293791	33/37 (89%)
		WD40 repeat	371..459	CDD:293791	43/87 (49%)
		WD40 repeat	465..490	CDD:293791	22/24 (92%)
lin-53	NP_492552.1	CAF1C_H4-bd	16..84	CDD:463513	47/68 (69%)
		WD40	<107..398	CDD:441893	219/339 (65%)
		WD40 repeat	124..170	CDD:293791	27/46 (59%)
		WD40 repeat	175..219	CDD:293791	25/43 (58%)
		WD40 repeat	226..262	CDD:293791	24/38 (63%)
		WD40 repeat	268..306	CDD:293791	33/37 (89%)
		WD40 repeat	312..363	CDD:293791	46/95 (48%)
		WD40 repeat	369..394	CDD:293791	22/24 (92%)